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Refl. Cr\u00edt."],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19. Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1\u03b2, IL-2, IL-6, IL-8, TNF-a, and IFN-\u03b3, along with GDNF, were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009.230, <jats:italic>p<\/jats:italic>\u2009=\u2009.021), obsessive\u2013compulsive symptoms (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009.201, <jats:italic>p<\/jats:italic>\u2009=\u2009.042). The levels of IL-8 were negatively associated with the anxiety score (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009-.223, <jats:italic>p<\/jats:italic>\u2009=\u2009.028), obsessive\u2013compulsive symptoms (Spearman\u2019s rho\u2009=\u2009-.252, <jats:italic>p<\/jats:italic>\u2009=\u2009.012), hyperarousal (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009-.221, <jats:italic>p<\/jats:italic>\u2009=\u2009.028). The levels of TNF-\u03b1 were positively associated with the anxiety score (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009.201, <jats:italic>p<\/jats:italic>\u2009=\u2009.045), obsessive\u2013compulsive symptoms (<jats:italic>Spearman\u2019s rho<\/jats:italic>\u2009=\u2009.222, <jats:italic>p<\/jats:italic>\u2009=\u2009.035).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Generally, our results suggested that IL-6, IL-8 and TNF-\u03b1 might play a role in the development of psychological symptoms among medical staff.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41155-024-00335-w","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:21:20Z","timestamp":1736137280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic"],"prefix":"10.1186","volume":"38","author":[{"given":"Dong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4352-1473","authenticated-orcid":false,"given":"Lijun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"335_CR1","doi-asserted-by":"publisher","unstructured":"Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. 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