{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:42:42Z","timestamp":1790376162156,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Med Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue haemorrhagic fever (DHF) is recognized to have high mortality in patients with chronic kidney disease (CKD) and heart failure (HF). They are at high risk of shock during the ascending limb of the critical phase of DHF, fluid overload during convalescence and bleeding throughout the entire illness. Physiological changes and medications used in CKD\/HF make the diagnosis and monitoring of DHF difficult. Treatment with standard fluid regimens also poses a challenge due to the propensity for fluid overload. As a result, standard dengue guidelines do not provide recommendations on fluid management regimens in DHF with CKD\/HF. This article provides a narrative review on the existing evidence for management of DHF in patients with volume-changed states such as HF, CKD and nephrotic\/ nephritic syndromes. It will explore the relevant diagnostic and therapeutic dilemmas, acknowledge the challenges for developing guidelines and recommend strategies to improve fluid management in these groups of patients.<\/jats:p>","DOI":"10.1186\/s41182-024-00600-9","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:01:56Z","timestamp":1713931316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dengue haemorrhagic fever in chronic kidney disease and heart failure: challenges in fluid management"],"prefix":"10.1186","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-1238","authenticated-orcid":false,"given":"Manudi","family":"Vidanapathirana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"issue":"4 Suppl","key":"600_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2149\/tmh.2011-S10","volume":"39","author":"S Kalayanarooj","year":"2011","unstructured":"Kalayanarooj S. Clinical manifestations and management of Dengue\/DHF\/DSS. Trop Med Health. 2011;39(4 Suppl):83\u20137. https:\/\/doi.org\/10.2149\/tmh.2011-S10.","journal-title":"Trop Med Health"},{"key":"600_CR2","unstructured":"National Epidemiology Unit. Guidelines on the Management of Dengue and Dengue Haemorrhagic Fever in Adults 2012.\u00a0https:\/\/www.epid.gov.lk\/web\/images\/pdf\/Publication\/guidelines_for_the_management_of_df_and_dhf_in_adults.pdf. Accessed 21 Feb 2024."},{"key":"600_CR3","volume-title":"Guidelines for dengue hemorrhagic fever case management","author":"S Kalayanarooj","year":"2004","unstructured":"Kalayanarooj S, Nimmannitya S. Guidelines for dengue hemorrhagic fever case management. Bangkok: Bangkok Medical Publisher; 2004."},{"issue":"2","key":"600_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1590\/S0103-507X2011000200004","volume":"23","author":"JC Verdeal","year":"2011","unstructured":"Verdeal JC, Costa Filho R, Vanzillotta C, Macedo GL, Bozza FA, Toscano L, Prata A, Tanner AC, Machado FR. Guidelines for the management of patients with severe forms of dengue. Rev Bras Ter Intensiva. 2011;23(2):125\u201333.","journal-title":"Rev Bras Ter Intensiva"},{"issue":"2","key":"600_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s12098-022-04394-8","volume":"90","author":"A Tayal","year":"2023","unstructured":"Tayal A, Kabra SK, Lodha R. Management of dengue: an updated review. Indian J Pediatr. 2023;90(2):168\u201377. https:\/\/doi.org\/10.1007\/s12098-022-04394-8.","journal-title":"Indian J Pediatr"},{"issue":"1","key":"600_CR6","first-page":"29","volume":"14","author":"DMPUK Ralapanawa","year":"2015","unstructured":"Ralapanawa DMPUK, Kularatne SAM. Current management of denguein adults: a review. Int Med J Malaysia. 2015;14(1):29\u201342.","journal-title":"Int Med J Malaysia"},{"issue":"1","key":"600_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00284-020-02284-w","volume":"78","author":"P Bhatt","year":"2021","unstructured":"Bhatt P, Sabeena SP, Varma M, Arunkumar G. Current understanding of the pathogenesis of dengue virus infection. Curr Microbiol. 2021;78(1):17\u201332. https:\/\/doi.org\/10.1007\/s00284-020-02284-w.","journal-title":"Curr Microbiol"},{"issue":"5","key":"600_CR8","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.2215\/CJN.00020108","volume":"3","author":"MC Kuo","year":"2008","unstructured":"Kuo MC, Lu PL, Chang JM, Lin MY, Tsai JJ, Chen YH, Chang K, Chen HC, Hwang SJ. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol. 2008;3(5):1350\u20136. https:\/\/doi.org\/10.2215\/CJN.00020108.","journal-title":"Clin J Am Soc Nephrol"},{"key":"600_CR9","doi-asserted-by":"publisher","first-page":"19783","DOI":"10.1038\/s41598-019-56381-3","volume":"9","author":"IK Lee","year":"2019","unstructured":"Lee IK, Yang ZS, Ng HY, et al. Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease. Sci Rep. 2019;9:19783. https:\/\/doi.org\/10.1038\/s41598-019-56381-3.","journal-title":"Sci Rep"},{"issue":"1","key":"600_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004284","volume":"10","author":"J Toledo","year":"2016","unstructured":"Toledo J, George L, Martinez E, Lazaro A, Han WW, Coelho GE, Runge Ranzinger S, Horstick O. Relevance of non-communicable comorbidities for the development of the severe forms of dengue: a systematic literature review. PLoS Negl Trop Dis. 2016;10(1): e0004284. https:\/\/doi.org\/10.1371\/journal.pntd.0004284.","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"600_CR11","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.jmii.2023.08.004","volume":"56","author":"I Lee","year":"2023","unstructured":"Lee I, et al. In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue. J Microbiol Immunol Infect. 2023;56(5):996\u20131006. https:\/\/doi.org\/10.1016\/j.jmii.2023.08.004.","journal-title":"J Microbiol Immunol Infect"},{"issue":"3","key":"600_CR12","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1016\/j.ekir.2023.02.090","volume":"8","author":"EF Daher","year":"2023","unstructured":"Daher EF, et al. WCN23\u20131247 CKD associated with increased mortality in dengue fever. Kidney Int Rep. 2023;8(3):S39\u201340. https:\/\/doi.org\/10.1016\/j.ekir.2023.02.090.","journal-title":"Kidney Int Rep"},{"key":"600_CR13","doi-asserted-by":"publisher","first-page":"39872","DOI":"10.1038\/srep39872","volume":"7","author":"J Pang","year":"2017","unstructured":"Pang J, Hsu J, Yeo T, et al. Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: a matched case-control study. Sci Rep. 2017;7:39872. https:\/\/doi.org\/10.1038\/srep39872.","journal-title":"Sci Rep"},{"issue":"6","key":"600_CR14","doi-asserted-by":"publisher","first-page":"36817","DOI":"10.1038\/srep36817","volume":"14","author":"LM Lim","year":"2016","unstructured":"Lim LM, Tsai NC, Lin MY, Hwang DY, Lin HY, Lee JJ, Hwang SJ, Hung CC, Chen HC. Hyponatremia is associated with fluid imbalance and adverse renal outcome in chronic kidney disease patients treated with diuretics. Sci Rep. 2016;14(6):36817. https:\/\/doi.org\/10.1038\/srep36817.","journal-title":"Sci Rep"},{"issue":"5\u20136","key":"600_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000090185","volume":"28","author":"C Haller","year":"2005","unstructured":"Haller C. Hypoalbuminemia in renal failure: pathogenesis and therapeutic considerations. Kidney Blood Press Res. 2005;28(5\u20136):307\u201310. https:\/\/doi.org\/10.1159\/000090185.","journal-title":"Kidney Blood Press Res"},{"issue":"6","key":"600_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/IPC.0000000000000761","volume":"27","author":"XM Lim","year":"2019","unstructured":"Lim XM, Lim CT. Dengue fever in end-stage renal failure patient: case report and updated literature review in the diagnostic and management challenges. Infect Dis Clin Pract. 2019;27(6):310\u20134. https:\/\/doi.org\/10.1097\/IPC.0000000000000761.","journal-title":"Infect Dis Clin Pract"},{"issue":"1","key":"600_CR17","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1186\/s12879-023-08415-5","volume":"23","author":"M Vidanapathirana","year":"2023","unstructured":"Vidanapathirana M, Atukorala I. Dengue hemorrhagic fever with bleeding and fluid overload in a patient with active lupus nephritis: a case report of diagnostic and therapeutic challenges. BMC Infect Dis. 2023;23(1):433. https:\/\/doi.org\/10.1186\/s12879-023-08415-5.","journal-title":"BMC Infect Dis"},{"key":"600_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13265","author":"ET Arun Thomas","year":"2018","unstructured":"Arun Thomas ET, George J, Sruthi D, Vineetha NS, Gracious N. Clinical course of dengue fever and its impact on renal function in renal transplant recipients and patients with chronic kidney disease. Nephrology. 2018. https:\/\/doi.org\/10.1111\/nep.13265.","journal-title":"Nephrology"},{"issue":"6","key":"600_CR19","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jmii.2019.08.005","volume":"53","author":"H-J Chen","year":"2020","unstructured":"Chen H-J, Tang H-J, Chin-Li L, Chien C-C. Warning signs and severe dengue in end stage renal disease dialysis patients. J Microbiol Immunol Infect. 2020;53(6):979\u201385. https:\/\/doi.org\/10.1016\/j.jmii.2019.08.005.","journal-title":"J Microbiol Immunol Infect"},{"issue":"37","key":"600_CR20","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.2174\/1381612820666140212194926","volume":"20","author":"S Palit","year":"2014","unstructured":"Palit S, Kendrick J. Vascular calcification in chronic kidney disease: role of disordered mineral metabolism. Curr Pharm Des. 2014;20(37):5829\u201333. https:\/\/doi.org\/10.2174\/1381612820666140212194926.","journal-title":"Curr Pharm Des"},{"issue":"6","key":"600_CR21","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1055\/s-0030-1269828","volume":"31","author":"JM Porcel","year":"2010","unstructured":"Porcel JM. Pleural effusions from congestive heart failure. Semin Respir Crit Care Med. 2010;31(6):689\u201397. https:\/\/doi.org\/10.1055\/s-0030-1269828.","journal-title":"Semin Respir Crit Care Med"},{"issue":"11","key":"600_CR22","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.cardfail.2016.01.015","volume":"22","author":"JL Grodin","year":"2016","unstructured":"Grodin JL, Lala A, Stevens SR, DeVore AD, Cooper LB, AbouEzzeddine OF, Mentz RJ, Groarke JD, Joyce E, Rosenthal JL, Vader JM, Tang WH. Clinical implications of serum albumin levels in acute heart failure: insights from DOSE-AHF and ROSE-AHF. J Card Fail. 2016;22(11):884\u201390. https:\/\/doi.org\/10.1016\/j.cardfail.2016.01.015.","journal-title":"J Card Fail"},{"issue":"8","key":"600_CR23","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/ejhf.1835","volume":"22","author":"J Cautela","year":"2020","unstructured":"Cautela J, Tartiere JM, Cohen-Solal A, Bellemain-Appaix A, Theron A, Tibi T, Januzzi JL Jr, Roubille F, Girerd N. Management of low blood pressure in ambulatory heart failure with reduced ejection fraction patients. Eur J Heart Fail. 2020;22(8):1357\u201365. https:\/\/doi.org\/10.1002\/ejhf.1835.","journal-title":"Eur J Heart Fail"},{"key":"600_CR24","unstructured":"Srisawat N et al. Critical care in dengue management South East Asian Journal of Tropical Medicine and Public Health. 2017; 48 (Supplement 1). https:\/\/www.tm.mahidol.ac.th\/seameo\/2017-48-suppl-1\/SAJ-2017-48-suppl-1-171.pdf."},{"key":"600_CR25","doi-asserted-by":"publisher","DOI":"10.4103\/mjhs.mjhs_85_23","author":"R Chatterjee","year":"2023","unstructured":"Chatterjee R, Halder P, Samajdar SS, Ghosal P, Mukherjee S, Jana K, Saha B. Correlation between hematocrit and inferior vena cava collapsibility in adult patients with dengue fever: a prospective, observational study at a tertiary care setup in Eastern India. MRIMS J Health Sci. 2023. https:\/\/doi.org\/10.4103\/mjhs.mjhs_85_23.","journal-title":"MRIMS J Health Sci"},{"issue":"1","key":"600_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4038\/sljr.v4i1.69","volume":"4","author":"I Kodikara","year":"2018","unstructured":"Kodikara I, Gamage DTK. Revisit to sonography in dengue management: a review. Sri Lanka J Radiol. 2018;4(1):1\u201315. https:\/\/doi.org\/10.4038\/sljr.v4i1.69.","journal-title":"Sri Lanka J Radiol"},{"issue":"2","key":"600_CR27","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1086\/318479","volume":"32","author":"NT Ngo","year":"2001","unstructured":"Ngo NT, Cao XT, Kneen R, Wills B, Nguyen VM, Nguyen TQ, Chu VT, Nguyen TT, Simpson JA, Solomon T, White NJ, Farrar J. Acute management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour. Clin Infect Dis. 2001;32(2):204\u201313. https:\/\/doi.org\/10.1086\/318479.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"600_CR28","doi-asserted-by":"publisher","first-page":"752","DOI":"10.4269\/ajtmh.2007.76.752","volume":"76","author":"M-C Kuo","year":"2007","unstructured":"Kuo M-C, et al. Difficulty in diagnosis and treatment of dengue hemorrhagic fever in patients with chronic renal failure: report of three cases of mortality. Am J Trop Med Hygiene. 2007;76(4):752\u20136.","journal-title":"Am J Trop Med Hygiene"},{"issue":"1","key":"600_CR29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4103\/jigims.jigims_50_23","volume":"10","author":"D Prithvi","year":"2024","unstructured":"Prithvi D, Kumar A, Kumar A. Fluid management strategy in dengue acute respiratory distress syndrome with chronic kidney disease: a case report. J Indira Gandhi Inst Med Sci. 2024;10(1):62\u20134. https:\/\/doi.org\/10.4103\/jigims.jigims_50_23.","journal-title":"J Indira Gandhi Inst Med Sci"},{"issue":"2","key":"600_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5812\/ircmj.60822","volume":"20","author":"NK Devaraj","year":"2018","unstructured":"Devaraj NK. Managing dengue fever in heart failure: a case report. Iranian Red Crescent Med J. 2018;20(2):1\u20134. https:\/\/doi.org\/10.5812\/ircmj.60822.","journal-title":"Iranian Red Crescent Med J"},{"key":"600_CR31","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12879-021-05971-6","volume":"21","author":"P Madanayake","year":"2021","unstructured":"Madanayake P, Jayawardena A, Wijekoon SL, et al. Fluid requirement in adult dengue haemorrhagic fever patients during the critical phase of the illness: an observational study. BMC Infect Dis. 2021;21:286. https:\/\/doi.org\/10.1186\/s12879-021-05971-6.","journal-title":"BMC Infect Dis"}],"container-title":["Tropical Medicine and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00600-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41182-024-00600-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00600-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:08:04Z","timestamp":1713931684000},"score":1,"resource":{"primary":{"URL":"https:\/\/tropmedhealth.biomedcentral.com\/articles\/10.1186\/s41182-024-00600-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["600"],"URL":"https:\/\/doi.org\/10.1186\/s41182-024-00600-9","relation":{},"ISSN":["1349-4147"],"issn-type":[{"value":"1349-4147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]},"assertion":[{"value":"25 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33"}}