{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:30:29Z","timestamp":1790620229988,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Med Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The number of dengue cases has increased dramatically in recent years. In Latin America, the number of cases and deaths in 2023 was the highest ever recorded. We report on a patient who had been infected with dengue virus during his stay in Costa Rica in September 2023, and developed the disease after returning to Japan. Plasma obtained from the patient was used for diagnosis and dengue virus serotyping by real-time PCR. The nucleotide sequence of the envelope region of dengue virus was then determined by the direct sequencing method, and this sequence was used for phylogenetic analyses. The patient was found to be infected with dengue virus type 3 genotype III. The sequence from the present case was more homologous with sequences registered in Florida, USA, associated with travel to Cuba in 2022 than with sequences registered in Costa Rica 10\u00a0years ago. The Pan American Health Organization reported that only dengue virus type 1 and 2 cases were reported in Costa Rica in 2019\u20132021, whereas dengue virus type 3 and 4 cases started being reported in 2022. In 2023, the reported numbers of cases with dengue virus types 3 and 4 exceeded those of dengue virus types 1 and 2. In addition, regional differences in endemic strains have been observed in Costa Rica. Our findings suggest that the dengue virus type 3 that infected the patient was more likely an influx of a strain that had been circulating in Caribbean countries such as Cuba in recent years, rather than a re-emergence of an indigenous virus in Costa Rica. The serotypes of dengue virus prevalent in Costa Rica have been changing since 2022. All four serotypes were prevalent in 2023, with a particularly sharp increase in the number of cases of dengue virus types 3 and 4. Future monitoring and surveillance are essential because changes in endemic serotypes can cause antibody-dependent enhancement, which can lead to severe dengue disease presentations.<\/jats:p>","DOI":"10.1186\/s41182-024-00620-5","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:15:42Z","timestamp":1722471342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dengue virus type 3 infection in a traveler returning from Costa Rica to Japan in 2023"],"prefix":"10.1186","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-3803","authenticated-orcid":false,"given":"Tadahiro","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Kubota-Koketsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Samune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi E.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Shirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"620_CR1","unstructured":"Dengue data application. World Health Organization, Geneva, Switzerland. https:\/\/ntdhq.shinyapps.io\/dengue5\/. Accessed 11 Mar 2024."},{"key":"620_CR2","unstructured":"Disease Outbreak News; Dengue \u2013 Global situation. World Health Organization, Geneva, Switzerland. 2023. https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2023-DON498. Accessed 11 Mar 2024."},{"key":"620_CR3","unstructured":"Dengue. Pan American Health Organization, Washington, D.C. https:\/\/www.paho.org\/en\/topics\/dengue. Accessed 11 Mar 2024."},{"key":"620_CR4","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3201\/eid2103.141662","volume":"21","author":"S Kutsuna","year":"2015","unstructured":"Kutsuna S, Kato Y, Moi ML, Kotaki A, Ota M, et al. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis. 2015;21:517\u201320.","journal-title":"Emerg Infect Dis"},{"key":"620_CR5","unstructured":"National Institute of Infectious Diseases (NIID), Japan. Manual of laboratory diagnosis of Dengue virus, Japan. 2014. https:\/\/www.niid.go.jp\/niid\/images\/lab-manual\/Dengue2014.pdf. Accessed 11 Mar 2024."},{"key":"620_CR6","unstructured":"NIID, Japan. Manual of laboratory diagnosis of Chikungunya virus, Japan. 2013. https:\/\/www.niid.go.jp\/niid\/images\/lab-manual\/CHIKV.v1.1.pdf. Accessed 11 Mar 2024."},{"key":"620_CR7","unstructured":"NIID, Japan. Manual of laboratory diagnosis of Zika virus, Japan. 2016. https:\/\/www.niid.go.jp\/niid\/images\/lab-manual\/zika_ver1_20160311.pdf. Accessed 11 Mar 2024."},{"key":"620_CR8","unstructured":"NIID, Japan. Manual of laboratory diagnosis of West Nie virus, Japan. 2008. NIID, Japan."},{"key":"620_CR9","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.3201\/eid1811.120014","volume":"18","author":"D Warrilow","year":"2012","unstructured":"Warrilow D, Northill JA, Pyke AT. Sources of dengue viruses imported into Queensland, Australia, 2002\u20132010. Emerg Infect Dis. 2012;18:1850\u20137. https:\/\/doi.org\/10.3201\/eid1811.120014.","journal-title":"Emerg Infect Dis"},{"key":"620_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/molbev\/msu300","volume":"32","author":"LT Nguyen","year":"2015","unstructured":"Nguyen LT, Schmidt HA, von Haeseler A, Minh BQ. IQ-TREE: A fast and effective stochastic algorithm for estimating maximum likelihood phylogenies. Mol Biol Evol. 2015;32:268\u201374.","journal-title":"Mol Biol Evol"},{"key":"620_CR11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1006\/viro.2002.1549","volume":"301","author":"V Wittke","year":"2002","unstructured":"Wittke V, Robb TE, Thu HM, Nisalak A, Nimmannitya S, et al. Extinction and rapid emergence of strains of dengue 3 virus during an interepidemic period. Virology. 2002;301:148\u201356.","journal-title":"Virology"},{"key":"620_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207220","author":"J Phadungsombat","year":"2018","unstructured":"Phadungsombat J, Lin MY, Srimark N, Yamanaka A, Nakayama EE, et al. Emergence of genotype cosmopolitan of dengue virus type 2 and genotype III of dengue virus type 3 in Thailand. PLoS ONE. 2018. https:\/\/doi.org\/10.1371\/journal.pone.0207220.","journal-title":"PLoS ONE"},{"key":"620_CR13","unstructured":"Costa Rica - Dengue cases. Pan American Health Organization, Washington, D.C. https:\/\/www3.paho.org\/data\/index.php\/en\/mnu-topics\/indicadores-dengue-en\/dengue-subnacional-en\/541-cri-dengue-casos-en.html. Accessed 11 Mar 2024."}],"container-title":["Tropical Medicine and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00620-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41182-024-00620-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00620-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:19:32Z","timestamp":1722471572000},"score":1,"resource":{"primary":{"URL":"https:\/\/tropmedhealth.biomedcentral.com\/articles\/10.1186\/s41182-024-00620-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["620"],"URL":"https:\/\/doi.org\/10.1186\/s41182-024-00620-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4279130\/v1","asserted-by":"object"}]},"ISSN":["1349-4147"],"issn-type":[{"value":"1349-4147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"16 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of the Research Institute for Microbial Diseases, Osaka University (approval number: 2023-15).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The consent for publication was obtained simultaneously with informed consent that was performed before sample collection.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"50"}}