{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:03:28Z","timestamp":1769551408423,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Luxembourg Ministry of Foreign and European Affairs","award":["PaReCIDS III"],"award-info":[{"award-number":["PaReCIDS III"]}]},{"name":"Lao Tropical and Public Health Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Med Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Individuals with latent tuberculosis infection (LTBI) have a high risk of active infection, morbidity and mortality. Healthcare workers are a group who have increased risk of infection and onward transmission to their patients and other susceptible individuals; however, LTBI is often undiagnosed, and individuals are asymptomatic. Interferon gamma release assays (IGRA) can detect evidence of TB infection in otherwise asymptomatic individuals and are a good indication of LTBI. Laos, a resource limited country in southeast Asia, has limited data on TB prevalence in the general population or in healthcare workers. This study aimed to estimate the prevalence of LTBI in Lao healthcare workers in Vientiane Capital.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Healthcare workers from high-risk departments from 3 central hospitals in Laos were included (n\u2009=\u2009196) and venous blood was tested by IGRA. A questionnaire was administered to determine their knowledge, attitude and practice towards TB and LTBI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>10.2% of the participants were positive by IGRA, none of whom were previously aware of their TB status. The questionnaire revealed that knowledge and awareness of TB and LTBI were low.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>A significant proportion of healthcare workers in this study had evidence of LTBI infection. These individuals were unaware of their TB status and we suggest that testing and treatment, as well as prevention strategies, should be routinely administered in Lao hospitals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41182-024-00677-2","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T08:13:39Z","timestamp":1735892019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Latent tuberculosis prevalence in healthcare workers in Laos: a cross-sectional study"],"prefix":"10.1186","volume":"53","author":[{"given":"Sypaseuth","family":"Duangmixay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriphone","family":"Virachith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"H\u00fcbschen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phitsada","family":"Siphanthong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakhone","family":"Suthepmany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somphou","family":"Sayasone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-0702","authenticated-orcid":false,"given":"Antony P.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"677_CR1","unstructured":"World Health Organisation. Tuberculosis: WHO fact sheet. 2023."},{"key":"677_CR2","unstructured":"World Health Organisation. Latent tuberculosis infection: Updated and consolidated guidelines for programmatic management. 2018."},{"key":"677_CR3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00655-2019","author":"A Cohen","year":"2019","unstructured":"Cohen A, Mathiasen VD, Sch\u00f6n T, Wejse C. The global prevalence of latent tuberculosis: a systematic review and meta-analysis. Eur Respir J. 2019. https:\/\/doi.org\/10.1183\/13993003.00655-2019.","journal-title":"Eur Respir J"},{"key":"677_CR4","unstructured":"Trauer JM, Moyo N, Tay EL, Dale K, Ragonnet R, McBryde ES, et al. Risk of active tuberculosis in the five years following infection \u22ef 15%? Chest http:\/\/journal.chestnet.org\/article\/S0012369215002494\/fulltext. Accessed 24 Nov 2024"},{"issue":"1","key":"677_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4049\/jimmunol.0903856","volume":"185","author":"PL Lin","year":"2010","unstructured":"Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. J Immunol. 2010;185(1):15\u201322.","journal-title":"J Immunol"},{"key":"677_CR6","doi-asserted-by":"crossref","unstructured":"Vantava S, Hefele L, Virachith S, Vannachone S, Khounvisith V, Nouanthong P, et al. Low seroprotection against diphtheria and tetanus in Lao adolescents. Trop Med Int Health https:\/\/pubmed.ncbi.nlm.nih.gov\/37199458\/. Accessed 4 Jun 2023","DOI":"10.1111\/tmi.13882"},{"key":"677_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197370","author":"M Pauly","year":"2018","unstructured":"Pauly M, Black AP, Khampanisong P, Nouanthong P, H\u00fcbschen JM, Nanthavong N, et al. Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: a retrospective study. PLoS One. 2018. https:\/\/doi.org\/10.1371\/journal.pone.0197370.","journal-title":"PLoS One"},{"key":"677_CR8","doi-asserted-by":"publisher","DOI":"10.5365\/wpsar.2022.13.3.874","author":"V Douangboupha","year":"2024","unstructured":"Douangboupha V, Binns PL, Khamphaphongphane B, Oulay VS, Sengsaiya K, Boupphaphanh T, et al. Factors contributing to a measles outbreak in a hard-to-reach rural village in Xaisomboun Province Lao People\u2019s Democratic Republic. Western Pac Surveill Response J. 2024. https:\/\/doi.org\/10.5365\/wpsar.2022.13.3.874.","journal-title":"Western Pac Surveill Response J"},{"key":"677_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.074","author":"D Kleine","year":"2020","unstructured":"Kleine D, Billamay S, Chanthavilay P, Mongkhoune S, Keokhamphoui C, Souksakhone C, et al. Pertussis in Lao PDR: Seroprevalence and disease. Int J Infect Dis. 2020. https:\/\/doi.org\/10.1016\/j.ijid.2020.03.074.","journal-title":"Int J Infect Dis"},{"key":"677_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123647","author":"AP Black","year":"2024","unstructured":"Black AP, Vilivong K, Nouanthong P, Souvannaso C, H\u00fcbschen JM, Muller CP. Serosurveillance of vaccine preventable diseases and hepatitis C in healthcare workers from Lao PDR. PLoS One. 2024. https:\/\/doi.org\/10.1371\/journal.pone.0123647.","journal-title":"PLoS One"},{"key":"677_CR11","first-page":"9","volume":"17","author":"TH Nguyen","year":"2009","unstructured":"Nguyen TH, Odermatt P, Slesak G, Barennes H. Risk of latent tuberculosis infection in children living in households with tuberculosis patients: a cross sectional survey in remote northern Lao People\u2019s Democratic Republic. BMC Infect Dis. 2009;17:9.","journal-title":"BMC Infect Dis"},{"key":"677_CR12","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268818002777","author":"Y Deng","year":"2019","unstructured":"Deng Y, Liu Y, Li Y, Jing H, Wang Y, Li X, et al. Isolation measures and protection awareness are significant for latent tuberculosis infection: a cross-sectional study based on T-SPOTTB among health care workers in China. Epidemiol Infect. 2019. https:\/\/doi.org\/10.1017\/S0950268818002777.","journal-title":"Epidemiol Infect"},{"key":"677_CR13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.60960","author":"W Klayut","year":"2024","unstructured":"Klayut W, Srisungngam S, Suphankong S, Sirichote P, Phetsuksiri B, Bunchoo S, et al. Prevalence, risk factors, and result features in the detection of latent tuberculosis infection in Thai healthcare workers using QuantiFERON-TB Gold Plus. Cureus. 2024. https:\/\/doi.org\/10.7759\/cureus.60960.","journal-title":"Cureus"},{"key":"677_CR14","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202365013","author":"J Rudeeaneksin","year":"2023","unstructured":"Rudeeaneksin J, Srisungngam S, Klayut W, Bunchoo S, Bhakdeenuan P, Phetsuksiri B. QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-tube assays for detecting latent tuberculosis infection in Thai healthcare workers. Rev Inst Med Trop Sao Paulo. 2023. https:\/\/doi.org\/10.1590\/s1678-9946202365013.","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"18","key":"677_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph17186876","volume":"17","author":"P Chanpho","year":"2020","unstructured":"Chanpho P, Chaiear N, Kamsa-Ard S. Factors associated with latent tuberculosis infection among the hospital employees in a tertiary hospital of Northeastern Thailand. Int J Environ Res Public Health. 2020;17(18):1\u201312.","journal-title":"Int J Environ Res Public Health"},{"key":"677_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02379-7","author":"Y An","year":"2023","unstructured":"An Y, Teo AKJ, Huot CY, Tieng S, Khun KE, Pheng SH, et al. They do not have symptoms \u2013 why do they need to take medicines? Challenges in tuberculosis preventive treatment among children in Cambodia: a qualitative study. BMC Pulm Med. 2023. https:\/\/doi.org\/10.1186\/s12890-023-02379-7.","journal-title":"BMC Pulm Med"},{"key":"677_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1265476","author":"H Alsdurf","year":"2023","unstructured":"Alsdurf H, Benedetti A, Buu TN, Adjobimey M, Cook VJ, Fisher D, et al. Human resource implications of expanding latent tuberculosis patient care activities. Front Med (Lausanne). 2023. https:\/\/doi.org\/10.3389\/fmed.2023.1265476.","journal-title":"Front Med (Lausanne)"}],"container-title":["Tropical Medicine and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00677-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41182-024-00677-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41182-024-00677-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:05:57Z","timestamp":1735895157000},"score":1,"resource":{"primary":{"URL":"https:\/\/tropmedhealth.biomedcentral.com\/articles\/10.1186\/s41182-024-00677-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["677"],"URL":"https:\/\/doi.org\/10.1186\/s41182-024-00677-2","relation":{},"ISSN":["1349-4147"],"issn-type":[{"value":"1349-4147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was obtained from the Lao National Ethics Committee for Health Research (Approval #34\/NECHR). In addition, all participants received detailed explanations about the study and provided signed informed consent forms prior to their participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}