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This study explores the key drivers behind the recent resurgence, focusing on epidemiological trends, transmission dynamics, and lessons learned from recent outbreaks. The research involved a comprehensive review of recent mpox outbreaks, analyzing factors, such as socio-economic conditions, environmental influences, and genetic evolution. Findings indicate that the resurgence is linked to the cessation of smallpox vaccination, increased human\u2013wildlife interactions, and rapid urbanization in endemic regions. The virus, which was previously confined to rural areas, has now spread to urban populations, and crossed national borders, driven by high population mobility and socio-economic instability. A notable shift in transmission dynamics has been observed, with increased human-to-human transmission, particularly among men who have sex with men (MSM), contributing to more severe and widespread outbreaks. The study highlights the urgent need to strengthen health systems in Africa, particularly in the areas of diagnostics, surveillance, and public health preparedness. Challenges such as inadequate laboratory infrastructure and delayed response mechanisms have exposed vulnerabilities in current public health frameworks. To prevent future outbreaks, targeted strategies must be implemented, including enhanced community engagement, improved access to vaccines and treatments, and timely, accurate reporting of cases. Coordinated global action is essential to prevent mpox from becoming a more persistent and widespread public health threat. This research discusses the importance of proactive measures and international cooperation in addressing the ongoing threat posed by mpox, particularly in regions with limited healthcare resources.<\/jats:p>","DOI":"10.1186\/s41182-024-00678-1","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:30:01Z","timestamp":1743748201000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Understanding the resurgence of mpox: key drivers and lessons from recent outbreaks in Africa"],"prefix":"10.1186","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-0340","authenticated-orcid":false,"given":"Adewunmi","family":"Akingbola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-5360","authenticated-orcid":false,"given":"Christopher Abiodun","family":"Adegbesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6372-2316","authenticated-orcid":false,"given":"Olajumoke","family":"Adewole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-4817","authenticated-orcid":false,"given":"Courage","family":"Idahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolani","family":"Odukoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Nwaeze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekoni","family":"Mayowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owolabi","family":"Abdullahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6322-4249","authenticated-orcid":false,"given":"Petra Kerubo","family":"Mariaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"678_CR1","unstructured":"Current ICTV Taxonomy Release | ICTV. https:\/\/ictv.global\/taxonomy"},{"issue":"2","key":"678_CR2","first-page":"165","volume":"58","author":"JG Breman","year":"1980","unstructured":"Breman JG, Null K-R, Steniowski MV, Zanotto E, Gromyko AI, Arita I. 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