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However, data on its prevalence, antimicrobial resistance (AMR) patterns, and associated serovars in Ghana are fragmented across multiple studies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>This systematic review and meta-analysis aimed to consolidate data on the prevalence, phenotypic and genotypic antimicrobial resistance profiles of NTS in Ghana.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Following PRISMA guidelines, a systematic search was conducted on August 8, 2024, across four databases: PubMed, ScienceDirect, Scopus, and Web of Science. A total of 31 studies were included. A random-effects model was used to estimate the pooled prevalence of NTS and the resistance levels of antibiotics reported in two or more studies. Subgroup analysis, multivariate analysis, sensitivity analysis, Egger\u2019s test, and forest plots were performed to explore variations, assess the influence of individual studies, test for publication bias, and visualize pooled estimates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The pooled prevalence of NTS was estimated at 4.69% (95% CI 2.65\u20138.16) with high heterogeneity observed among the studies (I<jats:sup>2<\/jats:sup>\u2009=\u200998.6%, \u03c4<jats:sup>2<\/jats:sup>\u2009=\u20091.22, \u03c4\u2009=\u20091.10, H\u2009=\u20098.55, Q\u2009=\u20091754.02, p value\u2009&lt;\u20090). Prevalence rates fluctuated over time: 6.27% (2008\u20132012), 2.09% (2013\u20132017), and 7.02% (2018\u20132023), with no significant trend observed (Q\u2009=\u20092.63, df\u2009=\u20092, p value\u2009=\u20090.27). Antimicrobial resistance (AMR) rates were high, with resistance to trimethoprim-sulfamethoxazole (56.7%), amoxicillin\/ampicillin (50.8%), tetracycline (46.7%), and ampicillin (36.2%). Cefotaxime had the lowest resistance at 18.6%. <jats:italic>Salmonella<\/jats:italic> Typhimurium was the most identified serovar (36.7%), followed by <jats:italic>S.<\/jats:italic> Enteritidis (7.9%), <jats:italic>S.<\/jats:italic> Rubislaw (4.9%), <jats:italic>S.<\/jats:italic> Dublin (3.7%), and <jats:italic>S.<\/jats:italic> Kentucky (3.6%). Several AMR genes including <jats:italic>gyrA<\/jats:italic>, <jats:italic>gyrB<\/jats:italic>, <jats:italic>qnrB2,<\/jats:italic> and <jats:italic>qnrB19<\/jats:italic> were identified in human and food samples.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Despite ongoing interventions, NTS remains a significant public health challenge in Ghana, with high AMR levels. The continued rise in resistance to critical antibiotics highlights the need for a One Health approach, improved diagnostics, enhanced surveillance, and targeted public health measures to control NTS and mitigate AMR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s41182-025-00731-7","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:01:59Z","timestamp":1751367719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and antimicrobial resistance patterns of nontyphoidal Salmonella in Ghana: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"53","author":[{"given":"Patience","family":"Sarkodie-Addo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill Clinton","family":"Aglomasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Donkor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"12","key":"731_CR1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s10096-016-2760-3","volume":"35","author":"SI Smith","year":"2016","unstructured":"Smith SI, Seriki A, Ajayi A. 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