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By using advanced 3D printing technology and virtual surgical planning, designing a patient-specific implant (PSI) to replace the defect and integrate a fibular graft for osseointegration, providing cortical bone strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 40-year-old female patient with recurrent pain and swelling in the left knee was diagnosed with a distal femoral GCT. Imaging studies confirmed a large lytic lesion with cortical thinning. After tumor excision, reconstruction was performed using a 3D-printed lattice metal implant designed for biological and mechanical integration. A 3D printed custom titanium plate was used additionally for structural support and a fibular graft was embedded within the implant for biological union.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative outcomes demonstrated progressive osseointegration, weight-bearing capability, and functional recovery. The patient regained maximum osseointegration with the completion of 6 months and full-strength unrestricted mobility at the end of 18 months postoperatively without recurrence. Radiographic follow-ups confirmed structural integrity and graft incorporation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study illustrates the successful application of a customized lattice metal implant integrated with a fibular graft, demonstrating its feasibility for large tumor-induced defects in weight-bearing regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41205-025-00282-x","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T11:17:08Z","timestamp":1752664628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reconstruction of a large distal femoral giant cell tumor using a 3D-printed condylar support lattice metal implant and fibular grafts: a novel biomechanical and surgical approach"],"prefix":"10.1186","volume":"11","author":[{"given":"Aashish","family":"Chaudhry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Kumar","family":"Sambharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Bahre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"282_CR1","doi-asserted-by":"publisher","unstructured":"Yazdanpanah Z, Johnston JD, Cooper DML, Chen X. 3D Bioprinted Scaffolds for Bone Tissue Engineering: State-Of-The-Art and Emerging Technologies. 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