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Microsomal prostaglandin E synthase-1 (mPGES-1), a terminal enzyme for prostaglandin (PG) E<jats:sub>2<\/jats:sub> biosynthesis, is highly expressed in the skin of psoriasis patients. However, the detailed role of mPGES-1 in psoriasis remains unclear. In the present study, we aimed to investigate the role of mPGES-1 in psoriasis-like skin inflammation induced by imiquimod (IMQ), a well-established model of psoriasis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Psoriasis was induced in mPGES-1-deficient (mPGES-1<jats:sup>\u2212\/\u2212<\/jats:sup>) and wild-type (WT) mice by administering IMQ for 6\u00a0days. Psoriasis was evaluated based on the scores of the macroscopic symptoms, including skin scaling, thickness, and redness, and on the histological features. The skin expression of mPGES-1 was determined by real-time polymerase chain reaction and Western blotting. The impact of mPGES-1 deficiency on T-cell immunity was determined by flow cytometry and \u03b3\u03b4 T-cell depletion in vivo with anti-T-cell receptor (TCR) \u03b3\u03b4 antibody.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The inflamed skin of mPGES-1<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed severe symptoms after the administration of IMQ. Histological analysis further showed significant exacerbation of psoriasis in mPGES-1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. In WT mice, the mPGES-1 expression was highly induced at both mRNA and protein levels in the skin, and PGE<jats:sub>2<\/jats:sub> increased significantly after IMQ administration, while the PGE<jats:sub>2<\/jats:sub> production was largely abolished in mPGES-1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. These data indicate that mPGES-1 is the main enzyme responsible for PGE<jats:sub>2<\/jats:sub> production in the skin. Furthermore, the lack of mPGES-1 increased the numbers of IL-17A-producing \u03b3\u03b4 T cells in the skin with IMQ-induced psoriasis, and \u03b3\u03b4 T-cell depletion resulted in a reduction of the facilitated psoriasis symptoms under the condition of mPGES-1 deficiency.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our study results demonstrate that mPGES-1 is the main enzyme responsible for skin PGE<jats:sub>2<\/jats:sub> production, and that mPGES-1 deficiency facilitates the development of psoriasis by affecting the development of T-cell-mediated immunity. Therefore, mPGES-1 might impact both skin inflammation and T-cell-mediated immunity associated with psoriasis.\n<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s41232-025-00385-2","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:18:15Z","timestamp":1749179895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice"],"prefix":"10.1186","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-1493","authenticated-orcid":false,"given":"Fumiaki","family":"Kojima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hioki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Arichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Maehana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhito A.","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"385_CR1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0009","author":"A Ahmed","year":"2013","unstructured":"Ahmed A, Leon A, Butler DC, Reichenberg J. 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