{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:56:14Z","timestamp":1789185374006,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03459"],"award-info":[{"award-number":["20H03459"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27663"],"award-info":[{"award-number":["23K27663"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm Regener"],"DOI":"10.1186\/s41232-025-00392-3","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:17:36Z","timestamp":1755227856000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preventive role of CD163-positive macrophages in postoperative peritoneal adhesions"],"prefix":"10.1186","volume":"45","author":[{"given":"Lianbo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hirao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Adawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Hibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"issue":"s2","key":"392_CR1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1463-1318.2007.01360.x","volume":"9","author":"MS Wilson","year":"2007","unstructured":"Wilson MS. Practicalities and costs of adhesions. Colorectal Dis. 2007;9(s2):60\u20135.","journal-title":"Colorectal Dis"},{"issue":"10000","key":"392_CR2","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/S0140-6736(15)00275-5","volume":"386","author":"A Bhangu","year":"2015","unstructured":"Bhangu A, S\u00f8reide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015;386(10000):1278\u201387.","journal-title":"Lancet"},{"issue":"1","key":"392_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.amjsurg.2010.02.008","volume":"201","author":"B Schn\u00fcriger","year":"2011","unstructured":"Schn\u00fcriger B, Barmparas G, Branco BC, Lustenberger T, Inaba K, Demetriades D. Prevention of postoperative peritoneal adhesions: a review of the literature. Am J Surg. 2011;201(1):111\u201321.","journal-title":"Am J Surg"},{"key":"392_CR4","doi-asserted-by":"crossref","unstructured":"Committee for Scientific Affairs, The Japanese Association for Thoracic Surgery, Hideyuki Shimizu, Morihito Okada, Akira Tangoku, Yuichiro Doki, Shunsuke Endo. Thoracic and cardiovascular surgeries in Japan during 2017. General Thoracic and Cardiovascular Surgery. 2020;68(4):414\u201349.","DOI":"10.1007\/s11748-020-01298-2"},{"issue":"1","key":"392_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-023-00477-9","volume":"18","author":"BAW van den Beukel","year":"2023","unstructured":"van den Beukel BAW, Toneman MK, van Veelen F, van Oud-Alblas MB, van Dongen K, Stommel MWJ, et al. Elective adhesiolysis for chronic abdominal pain reduces long-term risk of adhesive small bowel obstruction. World J Emerg Surg. 2023;18(1): 8.","journal-title":"World J Emerg Surg"},{"issue":"5","key":"392_CR6","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s00464-020-07621-5","volume":"35","author":"EJ Lier","year":"2021","unstructured":"Lier EJ, van den Beukel BAW, Gawria L, van der Wees PJ, van den Hil L, Bouvy ND, et al. Clinical adhesion score (CLAS): development of a novel clinical score for adhesion-related complications in abdominal and pelvic surgery. Surg Endosc. 2021;35(5):2159\u201368.","journal-title":"Surg Endosc"},{"issue":"1","key":"392_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/SLA.0000000000001286","volume":"263","author":"RPG ten Broek","year":"2016","unstructured":"ten Broek RPG, Bakkum EA, Laarhoven CJHM, van Goor H. Epidemiology and Prevention of Postsurgical Adhesions Revisited. Ann Surg. 2016;263(1):12.","journal-title":"Ann Surg"},{"issue":"13","key":"392_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104112","volume":"18","author":"S Wang","year":"2022","unstructured":"Wang S, Lu M, Wang W, Yu S, Yu R, Cai C, et al. Macrophage Polarization Modulated by NF-\u03baB in Polylactide Membranes-Treated Peritendinous Adhesion. Small. 2022;18(13): e2104112.","journal-title":"Small"},{"key":"392_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jss.2021.08.038","volume":"270","author":"H Kosaka","year":"2022","unstructured":"Kosaka H, Kaibori M, Chu DI, Stucchi AF, Sekimoto M. Role of substance P-dependent chemotactic signaling in postoperative adhesion formation. J Surg Res. 2022;270:49\u201357.","journal-title":"J Surg Res"},{"key":"392_CR10","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.actbio.2022.12.025","volume":"158","author":"J Zhou","year":"2023","unstructured":"Zhou J, Wang H, Chen H, Ling Y, Xi Z, Lv M, et al. pH-responsive nanocomposite hydrogel for simultaneous prevention of postoperative adhesion and tumor recurrence. Acta Biomater. 2023;158:228\u201338.","journal-title":"Acta Biomater"},{"issue":"2","key":"392_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s00795-020-00272-4","volume":"54","author":"M Kusunoki","year":"2021","unstructured":"Kusunoki M, Fujiwara Y, Komohara Y, Imamura Y, Honda R, Ohba T, et al. Hemoglobin-induced continuous activation of macrophages in endometriotic cysts: a potential mechanism of endometriosis development and carcinogenesis. Med Mol Morphol. 2021;54(2):122\u201332.","journal-title":"Med Mol Morphol"},{"issue":"2","key":"392_CR12","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/path.5987","volume":"258","author":"Y Shi","year":"2022","unstructured":"Shi Y, Li J, Chen H, Hu Y, Tang L, Wang Y, et al. Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2\/ERK1\/2\/HIF-1\u03b1-dependent signaling pathway. J Pathol. 2022;258(2):164\u201378.","journal-title":"J Pathol"},{"issue":"2","key":"392_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1002\/path.6170","volume":"261","author":"L Pascual-Ant\u00f3n","year":"2023","unstructured":"Pascual-Ant\u00f3n L, Sandoval P, Gonz\u00e1lez-Mateo GT, Kopytina V, Tomero-Sanz H, Arriero-Pa\u00eds EM, et al. Targeting carcinoma-associated mesothelial cells with antibody-drug conjugates in ovarian carcinomatosis. J Patholv. 2023;261(2):238\u201351.","journal-title":"J Patholv"},{"key":"392_CR14","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3389\/fphys.2018.00419","volume":"9","author":"P Krzyszczyk","year":"2018","unstructured":"Krzyszczyk P, Schloss R, Palmer A, Berthiaume F. The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol. 2018;9:419.","journal-title":"Front Physiol"},{"issue":"9","key":"392_CR15","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.21037\/jtd.2019.09.03","volume":"11","author":"T Nouno","year":"2019","unstructured":"Nouno T, Okamoto M, Ohnishi K, Kaieda S, Tominaga M, Zaizen Y, et al. Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients. J Thorac Dis. 2019;11(9):4005\u201317.","journal-title":"J Thorac Dis"},{"issue":"4","key":"392_CR16","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.transproceed.2017.01.063","volume":"49","author":"JS Costa","year":"2017","unstructured":"Costa JS, Alves R, Sousa V, Marinho C, Rom\u00e3ozinho C, Santos L, et al. Fibrogenesis in kidney transplant: dysfunction progress biomarkers. Transplant Proc. 2017;49(4):787\u201391.","journal-title":"Transplant Proc"},{"issue":"1","key":"392_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27612-x","volume":"12","author":"J Zindel","year":"2021","unstructured":"Zindel J, Mittner J, Bayer J, April-Monn SL, Kohler A, Nusse Y, et al. Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling. Nat Commun. 2021;12(1): 7316.","journal-title":"Nat Commun"},{"issue":"3","key":"392_CR18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.surg.2006.09.010","volume":"141","author":"RA Cahill","year":"2007","unstructured":"Cahill RA, Wang JH, Redmond HP. Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation. Surgery. 2007;141(3):403\u201310.","journal-title":"Surgery"},{"issue":"5","key":"392_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268178","volume":"17","author":"SH Seo","year":"2022","unstructured":"Seo SH, Choi GJ, Lee OH, Kang H. Effect of methylene blue on experimental postoperative adhesion: A systematic review and meta-analysis. PLoS ONE. 2022;17(5): e0268178.","journal-title":"PLoS ONE"},{"issue":"12","key":"392_CR20","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1158\/0008-5472.CAN-17-2011","volume":"78","author":"D Shiraishi","year":"2018","unstructured":"Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, et al. CD163 is required for protumoral activation of macrophages in human and murine sarcoma. Cancer Res. 2018;78(12):3255\u201366.","journal-title":"Cancer Res"},{"issue":"9","key":"392_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1162","volume":"9","author":"Y Fujiwara","year":"2020","unstructured":"Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, et al. CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. Clin Transl Immunology. 2020;9(9): e1162.","journal-title":"Clin Transl Immunology"},{"issue":"1","key":"392_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, et al. Inference and analysis of cell-cell communication using Cell Chat. Nat Commun. 2021;12(1):1088.","journal-title":"Nat Commun"},{"issue":"469","key":"392_CR23","doi-asserted-by":"publisher","first-page":"eaan6735","DOI":"10.1126\/scitranslmed.aan6735","volume":"10","author":"JM Tsai","year":"2018","unstructured":"Tsai JM, Sinha R, Seita J, Fernhoff N, Christ S, Koopmans T, et al. Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers. Sci Transl Med. 2018;10(469):eaan6735.","journal-title":"Sci Transl Med."},{"key":"392_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2482-11-30","volume":"11","author":"SV Pismensky","year":"2011","unstructured":"Pismensky SV, Kalzhanov ZR, Eliseeva MY, Kosmas IP, Mynbaev OA. Severe inflammatory reaction induced by peritoneal trauma is the key driving mechanism of postoperative adhesion formation. BMC Surg. 2011;11:30.","journal-title":"BMC Surg"},{"issue":"11","key":"392_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110991","volume":"13","author":"Y Lu","year":"2024","unstructured":"Lu Y, Elrod J, Herrmann M, Knopf J, Boettcher M. Neutrophil extracellular traps: a crucial factor in post-surgical abdominal adhesion formation. Cells. 2024;13(11): 991.","journal-title":"Cells"},{"issue":"6","key":"392_CR26","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1096\/fj.201600871RR","volume":"31","author":"K Honjo","year":"2017","unstructured":"Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, et al. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice. FASEB J. 2017;31(6):2625\u201337.","journal-title":"FASEB J"},{"issue":"1","key":"392_CR27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.surg.2006.01.020","volume":"140","author":"RA Cahill","year":"2006","unstructured":"Cahill RA, Wang JH, Soohkai S, Redmond HP. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery. 2006;140(1):108\u201312.","journal-title":"Surgery"},{"issue":"10","key":"392_CR28","doi-asserted-by":"publisher","first-page":"6970","DOI":"10.4049\/jimmunol.180.10.6970","volume":"180","author":"AO Tzianabos","year":"2008","unstructured":"Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, et al. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol. 2008;180(10):6970\u20136.","journal-title":"J Immunol"},{"issue":"1","key":"392_CR29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.7150\/ijbs.54403","volume":"17","author":"Q Hu","year":"2021","unstructured":"Hu Q, Xia X, Kang X, Song P, Liu Z, Wang M, et al. A review of physiological and cellular mechanisms underlying fibrotic postoperative adhesion. Int J Biol Sci. 2021;17(1):298\u2013306.","journal-title":"Int J Biol Sci"},{"issue":"3","key":"392_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106195","volume":"26","author":"MS Shutova","year":"2023","unstructured":"Shutova MS, Borowczyk J, Russo B, Sellami S, Drukala J, Wolnicki M, et al. Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2. iScience. 2023;26(3): 106195.","journal-title":"iScience"},{"key":"392_CR31","first-page":"404","volume":"22","author":"J Li","year":"2023","unstructured":"Li J, Zhao C, Xu Y, Song L, Chen Y, Xu Y, et al. Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: single-cell transcriptome analysis. Bioact Mater. 2023;22:404\u201322.","journal-title":"Bioact Mater"},{"issue":"6817","key":"392_CR32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/35051594","volume":"409","author":"M Kristiansen","year":"2001","unstructured":"Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SKA, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409(6817):198\u2013201.","journal-title":"Nature"},{"issue":"4","key":"392_CR33","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1002\/1521-4141(200104)31:4<999::AID-IMMU999>3.0.CO;2-R","volume":"31","author":"M Ritter","year":"2001","unstructured":"Ritter M, Buechler C, Kapinsky M, Schmitz G. Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur J Immunol. 2001;31(4):999\u20131009.","journal-title":"Eur J Immunol"},{"issue":"1","key":"392_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11010-008-9840-3","volume":"317","author":"M Strauss","year":"2008","unstructured":"Strauss M, Levy AP. Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent. Mol Cell Biochem. 2008;317(1):131\u20135.","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"392_CR35","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s00795-022-00323-y","volume":"55","author":"L Li","year":"2022","unstructured":"Li L, Irie T, Yoshii D, Komohara Y, Fujiwara Y, Esumi S, et al. M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma. Med Mol Morphol. 2022;55(3):236\u201347.","journal-title":"Med Mol Morphol"},{"issue":"5","key":"392_CR36","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0015-0282(00)00490-8","volume":"73","author":"AF Haney","year":"2000","unstructured":"Haney AF. Identification of macrophages at the site of peritoneal injury: evidence supporting a direct role for peritoneal macrophages in healing injured peritoneum. Fertil Steril. 2000;73(5):988\u201395.","journal-title":"Fertil Steril"},{"issue":"5","key":"392_CR37","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3109\/08941939.2010.496035","volume":"23","author":"A Hermanowicz","year":"2010","unstructured":"Hermanowicz A, Debek W, Oksiuta M, Matuszczak E. Peritoneal cell response during adhesion formation. J Invest Surg. 2010;23(5):267\u201372.","journal-title":"J Invest Surg"},{"issue":"18","key":"392_CR38","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1182\/bloodadvances.2018024026","volume":"3","author":"JM Tsai","year":"2019","unstructured":"Tsai JM, Shoham M, Fernhoff NB, George BM, Marjon KD, McCracken MN, et al. Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation. Blood Adv. 2019;3(18):2713\u201321.","journal-title":"Blood Adv"},{"issue":"1","key":"392_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27614-9","volume":"12","author":"M Honda","year":"2021","unstructured":"Honda M, Kadohisa M, Yoshii D, Komohara Y, Hibi T. Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury. Nat Commun. 2021;12(1): 7294.","journal-title":"Nat Commun"},{"key":"392_CR40","doi-asserted-by":"publisher","unstructured":"Saito Y, Fujiwara Y, Yamaguchi YL, Tanaka SS, Miura K, Hizukuri Y, et al. Rodent monocyte-derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians. Dev Dyn. 2025. https:\/\/doi.org\/10.1002\/dvdy.70036.\u00a0Online ahead of print.","DOI":"10.1002\/dvdy.70036"},{"key":"392_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102548","volume":"42","author":"M Cardoso","year":"2022","unstructured":"Cardoso M, Gaspar VM, Ferreira C, Silvestre R, Duarte IF, Mano JF. Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation. Nanomedicine. 2022;42: 102548.","journal-title":"Nanomedicine"},{"issue":"89","key":"392_CR42","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.actbio.2019.03.011","volume":"15","author":"R Tanaka","year":"2019","unstructured":"Tanaka R, Saito Y, Fujiwara Y, Jo JI, Tabata Y. Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages. Acta Biomater. 2019;15(89):152\u201365.","journal-title":"Acta Biomater"},{"issue":"12","key":"392_CR43","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1007\/s00464-003-8154-5","volume":"17","author":"SW Lee","year":"2003","unstructured":"Lee SW, Feingold DL, Carter JJ, Zhai C, Stapleton G, Gleason N, et al. Peritoneal macrophage and blood monocyte functions after open and laparoscopic-assisted cecectomy in rats. Surg Endosc. 2003;17(12):1996\u20132002.","journal-title":"Surg Endosc"},{"issue":"6","key":"392_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research. PLoS Biol. 2010;8(6): e1000412.","journal-title":"PLoS Biol"}],"container-title":["Inflammation and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41232-025-00392-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41232-025-00392-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41232-025-00392-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:09:56Z","timestamp":1757394596000},"score":1,"resource":{"primary":{"URL":"https:\/\/inflammregen.biomedcentral.com\/articles\/10.1186\/s41232-025-00392-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["392"],"URL":"https:\/\/doi.org\/10.1186\/s41232-025-00392-3","relation":{},"ISSN":["1880-8190"],"issn-type":[{"value":"1880-8190","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"10 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The investigation using human samples was carried out in accordance with the principles of the Declarations of Helsinki. The study design and protocol were approved by the review boards of Kumamoto University (#2224) and Izumi Hospital (#2020-660). All animal procedures were planned according to the Animal Research: Reporting In Vivo Experiments guideline [] and approved by the Animal Research Committee at Kumamoto University (#28\u2010003).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors has any conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26"}}