{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:31:47Z","timestamp":1792690307465,"version":"4.5.0"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm Regener"],"DOI":"10.1186\/s41232-026-00422-8","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:55:16Z","timestamp":1777622116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes"],"prefix":"10.1186","volume":"46","author":[{"given":"Xinqiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"422_CR1","doi-asserted-by":"crossref","unstructured":"Li X, Ding R, Cai J. Organ transplantation: current status, challenges, and future prospects. MedComm (2020). 2026;7(1):e70567.","DOI":"10.1002\/mco2.70567"},{"issue":"2","key":"422_CR2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/MOT.0000000000000959","volume":"27","author":"G Perottino","year":"2022","unstructured":"Perottino G, Harrington C, Levitsky J. Biomarkers of rejection in liver transplantation. Curr Opin Organ Transplant. 2022;27(2):154\u20138.","journal-title":"Curr Opin Organ Transplant"},{"issue":"3","key":"422_CR3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1053\/j.ajkd.2024.07.018","volume":"85","author":"SG Westphal","year":"2025","unstructured":"Westphal SG, Mannon RB. Biomarkers of rejection in kidney transplantation. Am J Kidney Dis. 2025;85(3):364\u201374.","journal-title":"Am J Kidney Dis"},{"key":"422_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005303","author":"AC Prosser","year":"2025","unstructured":"Prosser AC, Klenerman P, Lucas M. Understanding liver transplantation outcomes through the lens of its tissue-resident immunobiome. Transplantation. 2025. https:\/\/doi.org\/10.1097\/TP.0000000000005303.","journal-title":"Transplantation"},{"key":"422_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.890019","volume":"13","author":"X Li","year":"2022","unstructured":"Li X, Li S, Wu B, Xu Q, Teng D, Yang T, et al. Landscape of immune cells heterogeneity in liver transplantation by single-cell RNA sequencing analysis. Front Immunol. 2022;13:890019.","journal-title":"Front Immunol"},{"issue":"6","key":"422_CR6","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00281-022-00932-w","volume":"44","author":"LJ Pallett","year":"2022","unstructured":"Pallett LJ, Maini MK. Liver-resident memory T cells: life in lockdown. Semin Immunopathol. 2022;44(6):813\u201325.","journal-title":"Semin Immunopathol"},{"issue":"8","key":"422_CR7","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.immuni.2024.06.017","volume":"57","author":"NV Gavil","year":"2024","unstructured":"Gavil NV, Cheng K, Masopust D. Resident memory T cells and cancer. Immunity. 2024;57(8):1734\u201351.","journal-title":"Immunity"},{"issue":"1","key":"422_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/TP.0000000000004647","volume":"108","author":"KL Alexander","year":"2024","unstructured":"Alexander KL, Ford ML. The entangled world of memory T cells and implications in transplantation. Transplantation. 2024;108(1):137\u201347.","journal-title":"Transplantation"},{"issue":"6","key":"422_CR9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1097\/TP.0000000000004000","volume":"106","author":"J Fu","year":"2022","unstructured":"Fu J, Sykes M. Emerging concepts of tissue-resident memory T cells in transplantation. Transplantation. 2022;106(6):1132\u201342.","journal-title":"Transplantation"},{"issue":"6","key":"422_CR10","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/modpathol.2013.249","volume":"27","author":"CG Lian","year":"2014","unstructured":"Lian CG, Bueno EM, Granter SR, Laga AC, Saavedra AP, Lin WM, et al. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Mod Pathol. 2014;27(6):788\u201399.","journal-title":"Mod Pathol"},{"key":"422_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aah3732","author":"J Zuber","year":"2016","unstructured":"Zuber J, Shonts B, Lau SP, Obradovic A, Fu J, Yang S, et al. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Sci Immunol. 2016. https:\/\/doi.org\/10.1126\/sciimmunol.aah3732.","journal-title":"Sci Immunol"},{"issue":"12","key":"422_CR12","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.7150\/thno.96928","volume":"14","author":"X Li","year":"2024","unstructured":"Li X, Li S, Wang Y, Zhou X, Wang F, Muhammad I, et al. Single cell RNA-sequencing delineates CD8(+) tissue resident memory T cells maintaining rejection in liver transplantation. Theranostics. 2024;14(12):4844\u201360.","journal-title":"Theranostics"},{"issue":"1","key":"422_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-32785-2","volume":"16","author":"X Wang","year":"2025","unstructured":"Wang X, Li X, Cai H, Jia Z, Zhou X, Ding R, et al. Single-cell analysis indicating CCR8 modulates CD8(+) tissue-resident memory T cells to attenuates rejection in transplantation. Sci Rep. 2025;16(1):2936.","journal-title":"Sci Rep"},{"issue":"10","key":"422_CR14","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41577-023-00853-1","volume":"23","author":"E Rotrosen","year":"2023","unstructured":"Rotrosen E, Kupper TS. Assessing the generation of tissue resident memory T cells by vaccines. Nat Rev Immunol. 2023;23(10):655\u201365.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"422_CR15","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41590-022-01395-9","volume":"24","author":"MML Poon","year":"2023","unstructured":"Poon MML, Caron DP, Wang Z, Wells SB, Chen D, Meng W, et al. Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nat Immunol. 2023;24(2):309\u201319.","journal-title":"Nat Immunol"},{"issue":"5","key":"422_CR16","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.mucimm.2024.06.011","volume":"17","author":"J Tong","year":"2024","unstructured":"Tong J, Chen S, Gu X, Zhang X, Wei F, Xing Y. CD38 and extracellular NAD(+) regulate the development and maintenance of Hp vaccine-induced CD4(+) T(RM) in the gastric epithelium. Mucosal Immunol. 2024;17(5):990\u20131004.","journal-title":"Mucosal Immunol"},{"key":"422_CR17","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88204","author":"H Chen","year":"2023","unstructured":"Chen H, Qin Y, Chou M, Cyster JG, Li X. Transmembrane protein CD69 acts as an S1PR1 agonist. Elife. 2023. https:\/\/doi.org\/10.7554\/eLife.88204.","journal-title":"Elife"},{"key":"422_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1048758","volume":"13","author":"KR Plunkett","year":"2022","unstructured":"Plunkett KR, Armitage JD, Inderjeeth AJ, McDonnell AM, Waithman J, Lau PKH. Tissue-resident memory T cells in the era of (neo) adjuvant melanoma management. Front Immunol. 2022;13:1048758.","journal-title":"Front Immunol"},{"issue":"5","key":"422_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101466","volume":"19","author":"M Lal","year":"2025","unstructured":"Lal M, Burk CM, Gautam R, Mrozek Z, Canziani KE, Trachsel T, et al. Interferon-gamma signaling in eosinophilic esophagitis affects epithelial barrier function and programmed cell death. Cell Mol Gastroenterol Hepatol. 2025;19(5):101466.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"422_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.immuni.2020.06.002","volume":"53","author":"P Bourdely","year":"2020","unstructured":"Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, et al. Transcriptional and functional analysis of CD1c(+) human dendritic cells identifies a CD163(+) subset priming CD8(+)CD103(+) T Cells. Immunity. 2020;53(2):335-352 e338.","journal-title":"Immunity"},{"key":"422_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/497056","volume":"2015","author":"K Radulovic","year":"2015","unstructured":"Radulovic K, Niess JH. CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment? J Immunol Res. 2015;2015:497056.","journal-title":"J Immunol Res"},{"issue":"6","key":"422_CR22","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1053\/j.gastro.2023.10.022","volume":"166","author":"C Hu","year":"2024","unstructured":"Hu C, You W, Kong D, Huang Y, Lu J, Zhao M, et al. Tertiary lymphoid structure-associated B cells enhance CXCL13(+)CD103(+)CD8(+) tissue-resident memory T-cell response to programmed cell death protein 1 blockade in cancer immunotherapy. Gastroenterology. 2024;166(6):1069\u201384.","journal-title":"Gastroenterology"},{"issue":"1","key":"422_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04839-4","volume":"22","author":"G Yang","year":"2024","unstructured":"Yang G, Cai S, Hu M, Li C, Yang L, Zhang W, et al. Spatial features of specific CD103(+)CD8(+) tissue-resident memory T cell subsets define the prognosis in patients with non-small cell lung cancer. J Transl Med. 2024;22(1):27.","journal-title":"J Transl Med"},{"issue":"10","key":"422_CR24","doi-asserted-by":"publisher","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","volume":"188","author":"KA Casey","year":"2012","unstructured":"Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, et al. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol. 2012;188(10):4866\u201375.","journal-title":"J Immunol"},{"issue":"2","key":"422_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1189\/jlb.1HI0314-154R","volume":"97","author":"LK Beura","year":"2015","unstructured":"Beura LK, Anderson KG, Schenkel JM, Locquiao JJ, Fraser KA, Vezys V, et al. Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. J Leukoc Biol. 2015;97(2):217\u201325.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"422_CR26","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.immuni.2023.05.003","volume":"56","author":"B Zitti","year":"2023","unstructured":"Zitti B, Hoffer E, Zheng W, Pandey RV, Schlums H, Perinetti Casoni G, et al. Human skin-resident CD8(+) T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. Immunity. 2023;56(6):1285-1302 e1287.","journal-title":"Immunity"},{"key":"422_CR27","doi-asserted-by":"crossref","unstructured":"Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escaliere B, Galluso J, Wei H, Sun R, Vivier E et al. Liver type 1 innate lymphoid cells develop locally via an interferon-gamma-dependent loop. Science. 2021;371(6536):eaba4177.","DOI":"10.1126\/science.aba4177"},{"issue":"1","key":"422_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02859-2","volume":"25","author":"Y Alexandrova","year":"2024","unstructured":"Alexandrova Y, Yero A, Olivenstein R, Orlova M, Schurr E, Estaquier J, et al. Dynamics of pulmonary mucosal cytotoxic CD8 T-cells in people living with HIV under suppressive antiretroviral therapy. Respir Res. 2024;25(1):240.","journal-title":"Respir Res"},{"key":"422_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110530","volume":"121","author":"N Bao","year":"2023","unstructured":"Bao N, Fu B, Zhong X, Jia S, Ren Z, Wang H, et al. Role of the CXCR6\/CXCL16 axis in autoimmune diseases. Int Immunopharmacol. 2023;121:110530.","journal-title":"Int Immunopharmacol"},{"issue":"17","key":"422_CR30","doi-asserted-by":"publisher","first-page":"4512","DOI":"10.1016\/j.cell.2021.07.015","volume":"184","author":"M Di Pilato","year":"2021","unstructured":"Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, et al. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021;184(17):4512-4530 e4522.","journal-title":"Cell"},{"issue":"7854","key":"422_CR31","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41586-021-03233-8","volume":"592","author":"M Dudek","year":"2021","unstructured":"Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, et al. Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH. Nature. 2021;592(7854):444\u20139.","journal-title":"Nature"},{"issue":"2","key":"422_CR32","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jhep.2023.02.033","volume":"79","author":"N Yahoo","year":"2023","unstructured":"Yahoo N, Dudek M, Knolle P, Heikenwalder M. Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation. J Hepatol. 2023;79(2):538\u201351.","journal-title":"J Hepatol"},{"issue":"1","key":"422_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00836-5","volume":"30","author":"T Zhou","year":"2024","unstructured":"Zhou T, Lin L, Zhan Y, Zhang Z, Jiang Y, Wu M, et al. Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6(+)CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis. Mol Med. 2024;30(1):70.","journal-title":"Mol Med"},{"issue":"7","key":"422_CR34","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/eji.202149665","volume":"52","author":"L Parga-Vidal","year":"2022","unstructured":"Parga-Vidal L, Taggenbrock R, Beumer-Chuwonpad A, Aglmous H, Kragten NAM, Behr FM, et al. Hobit and Blimp-1 regulate T(RM) abundance after LCMV infection by suppressing tissue exit pathways of T(RM) precursors. Eur J Immunol. 2022;52(7):1095\u2013111.","journal-title":"Eur J Immunol"},{"key":"422_CR35","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg3533","volume":"6","author":"L Parga-Vidal","year":"2021","unstructured":"Parga-Vidal L, Behr FM, Kragten NAM, Nota B, Wesselink TH, Kavazovic I, et al. Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes. Sci Immunol. 2021;6:62.","journal-title":"Sci Immunol"},{"key":"422_CR36","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173489","volume":"9","author":"D Kirchmeier","year":"2024","unstructured":"Kirchmeier D, Deng Y, Rieble L, Boni M, Laderach F, Schuhmachers P, et al. Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues. JCI Insight. 2024;9:20.","journal-title":"JCI Insight"},{"issue":"9","key":"422_CR37","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/s41590-020-0723-4","volume":"21","author":"FM Behr","year":"2020","unstructured":"Behr FM, Parga-Vidal L, Kragten NAM, van Dam TJP, Wesselink TH, Sheridan BS, et al. Tissue-resident memory CD8(+) T cells shape local and systemic secondary T cell responses. Nat Immunol. 2020;21(9):1070\u201381.","journal-title":"Nat Immunol"},{"key":"422_CR38","doi-asserted-by":"crossref","unstructured":"Yan R, Jia D, Qi Y, Wang Q, Chen S. Intestinal tissue-resident memory T cells: Characteristics, spatial heterogeneity, age-related dynamics, and roles in disease regulation. J Adv Res. 2026;79:535\u201347.","DOI":"10.1016\/j.jare.2025.03.021"},{"issue":"10","key":"422_CR39","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202217240","volume":"15","author":"A Argyriou","year":"2023","unstructured":"Argyriou A, Horuluoglu B, Galindo-Feria AS, Diaz-Boada JS, Sijbranda M, Notarnicola A, et al. Single-cell profiling of muscle-infiltrating T cells in idiopathic inflammatory myopathies. EMBO Mol Med. 2023;15(10):e17240.","journal-title":"EMBO Mol Med"},{"issue":"6","key":"422_CR40","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13332","volume":"98","author":"K Chen","year":"2023","unstructured":"Chen K, Gu X, Yang S, Tao R, Fan M, Bao W, et al. Research progress on intestinal tissue-resident memory T cells in inflammatory bowel disease. Scand J Immunol. 2023;98(6):e13332.","journal-title":"Scand J Immunol"},{"issue":"8","key":"422_CR41","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/s41590-022-01273-4","volume":"23","author":"R Fonseca","year":"2022","unstructured":"Fonseca R, Burn TN, Gandolfo LC, Devi S, Park SL, Obers A, et al. Runx3 drives a CD8(+) T cell tissue residency program that is absent in CD4(+) T cells. Nat Immunol. 2022;23(8):1236\u201345.","journal-title":"Nat Immunol"},{"issue":"4","key":"422_CR42","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1053\/j.gastro.2021.06.025","volume":"161","author":"SC Sasson","year":"2021","unstructured":"Sasson SC, Slevin SM, Cheung VTF, Nassiri I, Olsson-Brown A, Fryer E, et al. Interferon-gamma-producing CD8(+) tissue resident memory T cells are a targetable hallmark of immune checkpoint inhibitor-colitis. Gastroenterology. 2021;161(4):1229-1244 e1229.","journal-title":"Gastroenterology"},{"key":"422_CR43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83981","author":"M Qing","year":"2023","unstructured":"Qing M, Yang D, Shang Q, Peng J, Deng J, Lu J, et al. CD8(+) tissue-resident memory T cells induce oral lichen planus erosion via cytokine network. Elife. 2023. https:\/\/doi.org\/10.7554\/eLife.83981.","journal-title":"Elife"},{"key":"422_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.735643","volume":"12","author":"T Peng","year":"2021","unstructured":"Peng T, Phasouk K, Sodroski CN, Sun S, Hwangbo Y, Layton ED, et al. Tissue-resident-memory CD8(+) T cells bridge innate immune responses in neighboring epithelial cells to control human genital herpes. Front Immunol. 2021;12:735643.","journal-title":"Front Immunol"},{"key":"422_CR45","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008739","author":"SG De Leon-Rodriguez","year":"2024","unstructured":"De Leon-Rodriguez SG, Aguilar-Flores C, Gajon JA, Juarez-Flores A, Mantilla A, Gerson-Cwilich R, et al. TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response. J Immunother Cancer. 2024. https:\/\/doi.org\/10.1136\/jitc-2023-008739.","journal-title":"J Immunother Cancer"},{"issue":"3","key":"422_CR46","doi-asserted-by":"publisher","first-page":"e518","DOI":"10.1093\/infdis\/jiae034","volume":"230","author":"KN McCarthy","year":"2024","unstructured":"McCarthy KN, Hone S, McLoughlin RM, Mills KHG. IL-17 and IFN-gamma-producing respiratory tissue-resident memory CD4 T cells persist for decades in adults immunized as children with whole-cell pertussis vaccines. J Infect Dis. 2024;230(3):e518\u201323.","journal-title":"J Infect Dis"},{"key":"422_CR47","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.154195","author":"L Mvaya","year":"2022","unstructured":"Mvaya L, Khaba T, Lakudzala AE, Nkosi T, Jambo N, Kadwala I, et al. Differential localization and limited cytotoxic potential of duodenal CD8+ T cells. JCI Insight. 2022. https:\/\/doi.org\/10.1172\/jci.insight.154195.","journal-title":"JCI Insight"},{"key":"422_CR48","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.184048","author":"K Moghbeli","year":"2025","unstructured":"Moghbeli K, Lipp MA, Bueno M, Craig A, Rojas M, Abbas M, et al. NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction. JCI Insight. 2025. https:\/\/doi.org\/10.1172\/jci.insight.184048.","journal-title":"JCI Insight"},{"issue":"1","key":"422_CR49","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-immunol-101320-020220","volume":"42","author":"SN Christo","year":"2024","unstructured":"Christo SN, Park SL, Mueller SN, Mackay LK. The multifaceted role of tissue-resident memory T cells. Annu Rev Immunol. 2024;42(1):317\u201345.","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"422_CR50","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41591-024-02895-x","volume":"30","author":"MF Thomas","year":"2024","unstructured":"Thomas MF, Slowikowski K, Manakongtreecheep K, Sen P, Samanta N, Tantivit J, et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nat Med. 2024;30(5):1349\u201362.","journal-title":"Nat Med"},{"issue":"1","key":"422_CR51","doi-asserted-by":"publisher","DOI":"10.1093\/oxfimm\/iqae006","volume":"5","author":"N Iijima","year":"2024","unstructured":"Iijima N. The emerging role of effector functions exerted by tissue-resident memory T cells. Oxf Open Immunol. 2024;5(1):iqae006.","journal-title":"Oxf Open Immunol"},{"issue":"1","key":"422_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42401-9","volume":"9","author":"K de Leur","year":"2019","unstructured":"de Leur K, Dieterich M, Hesselink DA, Corneth OBJ, Dor F, de Graav GN, et al. Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies. Sci Rep. 2019;9(1):5984.","journal-title":"Sci Rep"},{"key":"422_CR53","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav5581","author":"ME Snyder","year":"2019","unstructured":"Snyder ME, Finlayson MO, Connors TJ, Dogra P, Senda T, Bush E, et al. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Sci Immunol. 2019. https:\/\/doi.org\/10.1126\/sciimmunol.aav5581.","journal-title":"Sci Immunol"},{"key":"422_CR54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200050","author":"LJ Pallett","year":"2020","unstructured":"Pallett LJ, Burton AR, Amin OE, Rodriguez-Tajes S, Patel AA, Zakeri N, et al. Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes. J Exp Med. 2020. https:\/\/doi.org\/10.1084\/jem.20200050.","journal-title":"J Exp Med"},{"key":"422_CR55","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc8122","author":"KI Abou-Daya","year":"2021","unstructured":"Abou-Daya KI, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams AL, et al. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. sci immunol. 2021. https:\/\/doi.org\/10.1126\/sciimmunol.abc8122.","journal-title":"sci immunol"},{"issue":"5","key":"422_CR56","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1111\/ajt.16405","volume":"21","author":"J Weiner","year":"2021","unstructured":"Weiner J, Svetlicky N, Kang J, Sadat M, Khan K, Duttargi A, et al. CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation. am j transplant. 2021;21(5):1878\u201392.","journal-title":"am j transplant"},{"issue":"11","key":"422_CR57","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1111\/ajt.17154","volume":"22","author":"A He","year":"2022","unstructured":"He A, Sarwar A, Thole LML, Siegle J, Sattler A, Ashraf MI, et al. Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation. am j transplant. 2022;22(11):2529\u201347.","journal-title":"am j transplant"},{"issue":"4","key":"422_CR58","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk0270","volume":"8","author":"Q Tian","year":"2022","unstructured":"Tian Q, Zhang Z, Tan L, Yang F, Xu Y, Guo Y, et al. Skin and heart allograft rejection solely by long-lived alloreactive T(RM) cells in skin of severe combined immunodeficient mice. sci adv. 2022;8(4):eabk0270.","journal-title":"sci adv"},{"key":"422_CR59","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172681","author":"DM Hullegie-Peelen","year":"2023","unstructured":"Hullegie-Peelen DM, Tejeda Mora H, Hesselink DA, Bindels EM, van den Bosch TP, Clahsen-van Groningen MC, et al. Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants. jci insight. 2023. https:\/\/doi.org\/10.1172\/jci.insight.172681.","journal-title":"jci insight"},{"issue":"82","key":"422_CR60","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add8454","volume":"8","author":"R Tieu","year":"2023","unstructured":"Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, et al. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. sci immunol. 2023;8(82):eadd8454.","journal-title":"sci immunol"},{"issue":"8","key":"422_CR61","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.ajt.2024.02.030","volume":"24","author":"DM Hullegie-Peelen","year":"2024","unstructured":"Hullegie-Peelen DM, Tejeda-Mora H, Dieterich M, Heidt S, Bindels EMJ, Hoogduijn MJ, et al. Tissue-resident memory T cells in human kidney transplants have alloreactive potential. am j transplant. 2024;24(8):1406\u201313.","journal-title":"am j transplant"},{"key":"422_CR62","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230930","author":"J Fu","year":"2024","unstructured":"Fu J, Wang Z, Martinez M, Obradovic A, Jiao W, Frangaj K, et al. Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes. j exp med. 2024. https:\/\/doi.org\/10.1084\/jem.20230930.","journal-title":"j exp med"},{"key":"422_CR63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179709","author":"T Yokose","year":"2024","unstructured":"Yokose T, Szuter ES, Rosales I, Guinn MT, Liss AS, Baba T, et al. Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant tolerance. J Clin Invest. 2024. https:\/\/doi.org\/10.1172\/JCI179709.","journal-title":"J Clin Invest"},{"issue":"34","key":"422_CR64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401658121","volume":"121","author":"I Saha","year":"2024","unstructured":"Saha I, Chawla AS, Oliveira A, Elfers EE, Warrick K, Meibers HE, et al. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming. Proc Natl Acad Sci U S A. 2024;121(34):e2401658121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"422_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102104","volume":"86","author":"D Al-Adra","year":"2024","unstructured":"Al-Adra D, Lan R, Jennings H, Weinstein KN, Liu Y, Verhoven B, et al. Single cell RNA-sequencing identifies the effect of normothermic ex vivo liver perfusion on liver-resident T cells. Transpl Immunol. 2024;86:102104.","journal-title":"Transpl Immunol"},{"key":"422_CR66","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.164603","author":"DR Calabrese","year":"2022","unstructured":"Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, et al. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022. https:\/\/doi.org\/10.1172\/jci.insight.164603.","journal-title":"JCI Insight"},{"issue":"6","key":"422_CR67","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00281-022-00927-7","volume":"44","author":"N Asada","year":"2022","unstructured":"Asada N, Ginsberg P, Gagliani N, Mittrucker HW, Panzer U. Tissue-resident memory T cells in the kidney. Semin Immunopathol. 2022;44(6):801\u201311.","journal-title":"Semin Immunopathol"},{"key":"422_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020288","author":"C van der Putten","year":"2021","unstructured":"van der Putten C, Remmerswaal EBM, Terpstra ML, van der Bom ND, Kers J, Ten Berge IJM, et al. CD8 and CD4 T cell populations in human kidneys. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10020288.","journal-title":"Cells"},{"key":"422_CR69","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba4163","author":"CF Krebs","year":"2020","unstructured":"Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nunez S, et al. Pathogen-induced tissue-resident memory T(H)17 (T(RM)17) cells amplify autoimmune kidney disease. Sci Immunol. 2020. https:\/\/doi.org\/10.1126\/sciimmunol.aba4163.","journal-title":"Sci Immunol"},{"issue":"5","key":"422_CR70","doi-asserted-by":"publisher","first-page":"F839","DOI":"10.1152\/ajprenal.00373.2023","volume":"326","author":"KH Moore","year":"2024","unstructured":"Moore KH, Erman EN, Traylor AM, Esman SK, Jiang Y, LaFontaine JR, et al. Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease. Am J Physiol Renal Physiol. 2024;326(5):F839\u201354.","journal-title":"Am J Physiol Renal Physiol"},{"key":"422_CR71","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112457","author":"LM Bartsch","year":"2020","unstructured":"Bartsch LM, Damasio MPS, Subudhi S, Drescher HK. Tissue-resident memory T cells in the liver-unique characteristics of local specialists. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9112457.","journal-title":"Cells"},{"key":"422_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.967055","volume":"13","author":"Y Li","year":"2022","unstructured":"Li Y, You Z, Tang R, Ma X. Tissue-resident memory T cells in chronic liver diseases: phenotype, development and function. Front Immunol. 2022;13:967055.","journal-title":"Front Immunol"},{"issue":"7","key":"422_CR73","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1136\/gutjnl-2020-323771","volume":"71","author":"BG Wiggins","year":"2022","unstructured":"Wiggins BG, Pallett LJ, Li X, Davies SP, Amin OE, Gill US, et al. The human liver microenvironment shapes the homing and function of CD4(+) T-cell populations. Gut. 2022;71(7):1399\u2013411.","journal-title":"Gut"},{"issue":"10","key":"422_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100812","volume":"5","author":"O Ibidapo-Obe","year":"2023","unstructured":"Ibidapo-Obe O, Bruns T. Tissue-resident and innate-like T cells in patients with advanced chronic liver disease. JHEP Rep. 2023;5(10):100812.","journal-title":"JHEP Rep"},{"key":"422_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010283","author":"JW Han","year":"2020","unstructured":"Han JW, Shin EC. Liver-resident memory CD8(+) T cells: possible roles in chronic HBV infection. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms22010283.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"422_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24734-0","volume":"12","author":"Y Koda","year":"2021","unstructured":"Koda Y, Teratani T, Chu PS, Hagihara Y, Mikami Y, Harada Y, et al. CD8(+) tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells. Nat Commun. 2021;12(1):4474.","journal-title":"Nat Commun"},{"issue":"1","key":"422_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46654-5","volume":"15","author":"HX Zhu","year":"2024","unstructured":"Zhu HX, Yang SH, Gao CY, Bian ZH, Chen XM, Huang RR, et al. Targeting pathogenic CD8(+) tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis. Nat Commun. 2024;15(1):2936.","journal-title":"Nat Commun"},{"issue":"9","key":"422_CR78","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/s41590-023-01562-6","volume":"24","author":"M Ganley","year":"2023","unstructured":"Ganley M, Holz LE, Minnell JJ, de Menezes MN, Burn OK, Poa KCY, et al. mRNA vaccine against malaria tailored for liver-resident memory T cells. Nat Immunol. 2023;24(9):1487\u201398.","journal-title":"Nat Immunol"},{"issue":"2","key":"422_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115295","volume":"44","author":"YC Chua","year":"2025","unstructured":"Chua YC, Draper SL, Le S, de Menezes MN, Ganley M, Ge Z, et al. Mechanistic insight into the induction of liver tissue-resident memory CD8(+) T cells by glycolipid-peptide vaccination. Cell Rep. 2025;44(2):115295.","journal-title":"Cell Rep"},{"issue":"1","key":"422_CR80","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/imr.13201","volume":"316","author":"IS Cheon","year":"2023","unstructured":"Cheon IS, Son YM, Sun J. Tissue-resident memory T cells and lung immunopathology. Immunol Rev. 2023;316(1):63\u201383.","journal-title":"Immunol Rev"},{"issue":"8","key":"422_CR81","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.immuni.2024.06.016","volume":"57","author":"S van de Wall","year":"2024","unstructured":"van de Wall S, Anthony SM, Hancox LS, Pewe LL, Langlois RA, Zehn D, et al. Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8(+) T cells revealed by intravital imaging. Immunity. 2024;57(8):1878-1892 e1875.","journal-title":"Immunity"},{"issue":"11","key":"422_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111828","volume":"41","author":"T Kawasaki","year":"2022","unstructured":"Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, et al. Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung. Cell Rep. 2022;41(11):111828.","journal-title":"Cell Rep"},{"issue":"63","key":"422_CR83","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf1198","volume":"6","author":"N Iwanaga","year":"2021","unstructured":"Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, et al. Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling. Sci Immunol. 2021;6(63):eabf1198.","journal-title":"Sci Immunol"},{"issue":"36","key":"422_CR84","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg3469","volume":"9","author":"MZM Zheng","year":"2023","unstructured":"Zheng MZM, Tan TK, Villalon-Letelier F, Lau H, Deng YM, Fritzlar S, et al. Single-cycle influenza virus vaccine generates lung CD8(+) Trm that cross-react against viral variants and subvert virus escape mutants. Sci Adv. 2023;9(36):eadg3469.","journal-title":"Sci Adv"},{"issue":"11","key":"422_CR85","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1164\/rccm.202305-0924OC","volume":"208","author":"AB Villasenor-Altamirano","year":"2023","unstructured":"Villasenor-Altamirano AB, Jain D, Jeong Y, Menon JA, Kamiya M, Haider H, et al. Activation of CD8(+) T cells in chronic obstructive pulmonary disease lung. Am J Respir Crit Care Med. 2023;208(11):1177\u201395.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"422_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.019","volume":"41","author":"CE Weeden","year":"2023","unstructured":"Weeden CE, Gayevskiy V, Marceaux C, Batey D, Tan T, Yokote K, et al. Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer. Cancer Cell. 2023;41(5):e836.","journal-title":"Cancer Cell"},{"issue":"7870","key":"422_CR87","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41586-021-03752-4","volume":"596","author":"JX Caushi","year":"2021","unstructured":"Caushi JX, Zhang J, Ji Z, Vaghasia A, Zhang B, Hsiue EH, et al. Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Nature. 2021;596(7870):126\u201332.","journal-title":"Nature"},{"issue":"23","key":"422_CR88","doi-asserted-by":"publisher","first-page":"10466","DOI":"10.7150\/thno.45211","volume":"10","author":"Y Chen","year":"2020","unstructured":"Chen Y, Yan Y, Liu H, Qiu F, Liang CL, Zhang Q, et al. Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice. Theranostics. 2020;10(23):10466\u201382.","journal-title":"Theranostics"},{"key":"422_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1460250","volume":"15","author":"G Liu","year":"2024","unstructured":"Liu G, Wang Z, Li S. Corrigendum: heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review. Front Immunol. 2024;15:1460250.","journal-title":"Front Immunol"},{"key":"422_CR90","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210417","author":"J Strobl","year":"2021","unstructured":"Strobl J, Gail LM, Kleissl L, Pandey RV, Smejkal V, Huber J, et al. Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation. J Exp Med. 2021. https:\/\/doi.org\/10.1084\/jem.20210417.","journal-title":"J Exp Med"},{"issue":"70","key":"422_CR91","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl9165","volume":"7","author":"Y Liu","year":"2022","unstructured":"Liu Y, Wang H, Taylor M, Cook C, Martinez-Berdeja A, North JP, et al. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci Immunol. 2022;7(70):eabl9165.","journal-title":"Sci Immunol"},{"issue":"42","key":"422_CR92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2323052121","volume":"121","author":"H Kalinoski","year":"2024","unstructured":"Kalinoski H, Daoud A, Rusinkevich V, Jurcova I, Talor MV, Welsh RA, et al. Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis. Proc Natl Acad Sci U S A. 2024;121(42):e2323052121.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"422_CR93","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s44161-024-00532-x","volume":"3","author":"V Vyas","year":"2024","unstructured":"Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, et al. Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation. Nat Cardiovasc Res. 2024;3(9):1067\u201382.","journal-title":"Nat Cardiovasc Res"},{"key":"422_CR94","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb7028","author":"J Strobl","year":"2020","unstructured":"Strobl J, Pandey RV, Krausgruber T, Bayer N, Kleissl L, Reininger B, et al. Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease. Sci Transl Med. 2020. https:\/\/doi.org\/10.1126\/scitranslmed.abb7028.","journal-title":"Sci Transl Med"},{"issue":"1","key":"422_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.007","volume":"56","author":"YH Lin","year":"2023","unstructured":"Lin YH, Duong HG, Limary AE, Kim ES, Hsu P, Patel SA, et al. Small intestine and colon tissue-resident memory CD8(+) T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity. 2023;56(1):e208.","journal-title":"Immunity"},{"key":"422_CR96","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210923","author":"Z Qiu","year":"2023","unstructured":"Qiu Z, Khairallah C, Chu TH, Imperato JN, Lei X, Romanov G, et al. Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation. J Exp Med. 2023. https:\/\/doi.org\/10.1084\/jem.20210923.","journal-title":"J Exp Med"},{"issue":"6","key":"422_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114258","volume":"43","author":"L Wang","year":"2024","unstructured":"Wang L, Mishra S, Fan KK, Quon S, Li G, Yu B, et al. T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells. Cell Rep. 2024;43(6):114258.","journal-title":"Cell Rep"},{"issue":"1","key":"422_CR98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204269120","volume":"120","author":"T Yokoi","year":"2023","unstructured":"Yokoi T, Murakami M, Kihara T, Seno S, Arase M, Wing JB, et al. Identification of a unique subset of tissue-resident memory CD4(+) T cells in Crohn\u2019s disease. Proc Natl Acad Sci U S A. 2023;120(1):e2204269120.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"422_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103206","volume":"145","author":"Y Lee","year":"2024","unstructured":"Lee Y, Baek J, Park S, Kim Y, Hwang SW, Lee JL, et al. Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn\u2019s disease patients. J Autoimmun. 2024;145:103206.","journal-title":"J Autoimmun"},{"issue":"1","key":"422_CR100","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04978-2","volume":"22","author":"J Fang","year":"2024","unstructured":"Fang J, Lei J, He B, Wu Y, Chen P, Sun Z, et al. Decoding the transcriptional heterogeneity, differentiation lineage, clinical significance in tissue-resident memory CD8 T cell of the small intestine by single-cell analysis. J Transl Med. 2024;22(1):203.","journal-title":"J Transl Med"},{"issue":"11","key":"422_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.09.013","volume":"57","author":"JL Raynor","year":"2024","unstructured":"Raynor JL, Collins N, Shi H, Guy C, Saravia J, Ah Lim S, et al. CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8(+) T cell formation. Immunity. 2024;57(11):e2513.","journal-title":"Immunity"},{"issue":"12","key":"422_CR102","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/LVT.0000000000000425","volume":"30","author":"G Tian","year":"2024","unstructured":"Tian G, Song S, Zhi Y, Qiu W, Chen Y, Sun X, et al. Alloreactive T cells temporarily increased in the peripheral blood of patients before liver allograft rejection. Liver Transpl. 2024;30(12):1250\u201363.","journal-title":"Liver Transpl"},{"issue":"2","key":"422_CR103","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ajt.2024.10.006","volume":"25","author":"N Saravanan","year":"2025","unstructured":"Saravanan N, Demetris A, Fiel MI, Harrington C, Khurram NA, Schiano TD, et al. Serum and tissue biomarkers of plasma cell-rich rejection in liver transplant recipients. Am J Transplant. 2025;25(2):259\u201368.","journal-title":"Am J Transplant"},{"issue":"3","key":"422_CR104","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14475","volume":"27","author":"AL Peters","year":"2023","unstructured":"Peters AL, Rogers M, Begum G, Sun Q, Fei L, Leino D, et al. T-cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients. Pediatr Transplant. 2023;27(3):e14475.","journal-title":"Pediatr Transplant"},{"issue":"12","key":"422_CR105","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1097\/TP.0000000000005107","volume":"108","author":"T Hirai","year":"2024","unstructured":"Hirai T, Kondo A, Shimizu T, Fukuda H, Tokita D, Takagi T, et al. Unveiling spatial immune cell profile in kidney allograft rejections using 36-plex immunofluorescence imaging. Transplantation. 2024;108(12):2446\u201357.","journal-title":"Transplantation"},{"issue":"5","key":"422_CR106","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.14336\/AD.2022.0224","volume":"13","author":"L Tan","year":"2022","unstructured":"Tan L, Xu Y, Lan G, Wang H, Liang Z, Zhang Z, et al. Absence of TSC1 accelerates CD8(+) T cell-mediated acute cardiac allograft rejection. Aging Dis. 2022;13(5):1562\u201375.","journal-title":"Aging Dis"},{"key":"422_CR107","doi-asserted-by":"crossref","unstructured":"Fueyo-Gonzalez F, McGinty M, Ningoo M, Anderson L, Cantarelli C, Andrea A, Demir M, Llaudo I, Purroy C, Marjanovic N et al: Interferon-beta acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation. Immunity. 2022:55(3):459\u2013474 e457.","DOI":"10.1016\/j.immuni.2022.01.011"},{"issue":"2","key":"422_CR108","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ajt.2022.12.011","volume":"23","author":"CR Hartigan","year":"2023","unstructured":"Hartigan CR, Tong KP, Liu D, Laurie SJ, Ford ML. TIGIT agonism alleviates costimulation blockade-resistant rejection in a regulatory T cell-dependent manner. Am J Transplant. 2023;23(2):180\u20139.","journal-title":"Am J Transplant"},{"key":"422_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2024.106860","volume":"267","author":"I Righi","year":"2024","unstructured":"Righi I, Trabattoni D, Rosso L, Vaira V, Clerici M. Immune checkpoint molecules in solid organ transplantation: a promising way to prevent rejection. Immunol Lett. 2024;267:106860.","journal-title":"Immunol Lett"},{"issue":"5","key":"422_CR110","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jaccao.2022.07.013","volume":"4","author":"T Yeung","year":"2022","unstructured":"Yeung T, McLean C, Kaye DM, Leet A, Patel HC, Bergin P, et al. Immune checkpoint inhibitor myocarditis and cellular rejection in orthotopic heart transplant recipients. JACC CardioOncol. 2022;4(5):717\u201321.","journal-title":"JACC CardioOncol"},{"issue":"5","key":"422_CR111","doi-asserted-by":"publisher","first-page":"866","DOI":"10.3724\/abbs.2023088","volume":"55","author":"J Chen","year":"2023","unstructured":"Chen J, Cao Y, Jia O, Wang X, Luo Y, Cheuk YC, et al. Monomethyl fumarate prevents alloimmune rejection in mouse heart transplantation by inducing tolerogenic dendritic cells. Acta Biochim Biophys Sin. 2023;55(5):866\u201377.","journal-title":"Acta Biochim Biophys Sin"},{"issue":"9","key":"422_CR112","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.ajt.2024.03.020","volume":"24","author":"M Sepulveda","year":"2024","unstructured":"Sepulveda M, Rasic M, Lei YM, Kwan M, Chen L, Chen Y, et al. Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival. Am J Transplant. 2024;24(9):1573\u201382.","journal-title":"Am J Transplant"},{"key":"422_CR113","doi-asserted-by":"publisher","DOI":"10.3390\/nano14010067","author":"S Kusumoputro","year":"2023","unstructured":"Kusumoputro S, Au C, Lam KH, Park N, Hyun A, Kusumoputro E, et al. Liver-targeting nanoplatforms for the induction of immune tolerance. Nanomaterials (Basel). 2023. https:\/\/doi.org\/10.3390\/nano14010067.","journal-title":"Nanomaterials (Basel)"},{"key":"422_CR114","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686439","volume":"12","author":"YD Muller","year":"2021","unstructured":"Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, et al. Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance. Front Immunol. 2021;12:686439.","journal-title":"Front Immunol"},{"issue":"2","key":"422_CR115","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/hep.31036","volume":"72","author":"J Levitsky","year":"2020","unstructured":"Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian S, Sanchez-Fueyo A, et al. Immunosuppression withdrawal in liver transplant recipients on sirolimus. Hepatology. 2020;72(2):569\u201383.","journal-title":"Hepatology"},{"issue":"10","key":"422_CR116","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1111\/ajt.17107","volume":"22","author":"P Wang","year":"2022","unstructured":"Wang P, Chen L, McIntosh CM, Lane JI, Li R, Xie SZ, et al. Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation. Am J Transplant. 2022;22(10):2348\u201359.","journal-title":"Am J Transplant"},{"issue":"94","key":"422_CR117","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adh0085","volume":"9","author":"J Cui","year":"2024","unstructured":"Cui J, Xu H, Yu J, Ran S, Zhang X, Li Y, et al. Targeted depletion of PD-1-expressing cells induces immune tolerance through peripheral clonal deletion. Sci Immunol. 2024;9(94):eadh0085.","journal-title":"Sci Immunol"},{"key":"422_CR118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.537079","volume":"12","author":"M Ding","year":"2021","unstructured":"Ding M, He Y, Zhang S, Guo W. Recent advances in costimulatory blockade to induce immune tolerance in liver transplantation. Front Immunol. 2021;12:537079.","journal-title":"Front Immunol"},{"key":"422_CR119","doi-asserted-by":"crossref","unstructured":"Tanimine N, Markmann JF, Wood-Trageser MA, Demetris AJ, Mason K, Silva JAF, Levitsky J, Feng S, Humar A, Emond JC et al. Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: results of a prospective, multicenter cohort study. Am J Transplant. 2025;25(5):1030\u201344.","DOI":"10.1016\/j.ajt.2024.10.022"},{"issue":"9","key":"422_CR120","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/s41423-024-01197-z","volume":"21","author":"F Arnold","year":"2024","unstructured":"Arnold F, Kupferschmid L, Weissenborn P, Heldmann L, Hummel JF, Zareba P, Sagar, Rogg M, Schell C, Tanriver Y. Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis. Cell Mol Immunol. 2024;21(9):1066\u201381.","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"422_CR121","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.4049\/jimmunol.1502337","volume":"196","author":"JM Schenkel","year":"2016","unstructured":"Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, et al. IL-15-independent maintenance of tissue-resident and boosted effector memory CD8 T cells. J Immunol. 2016;196(9):3920\u20136.","journal-title":"J Immunol"},{"issue":"6","key":"422_CR122","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.immuni.2015.11.008","volume":"43","author":"LK Mackay","year":"2015","unstructured":"Mackay LK, Wynne-Jones E, Freestone D, Pellicci DG, Mielke LA, Newman DM, et al. T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate. Immunity. 2015;43(6):1101\u201311.","journal-title":"Immunity"},{"key":"422_CR123","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam7710","author":"JM Richmond","year":"2018","unstructured":"Richmond JM, Strassner JP, Zapata L Jr., Garg M, Riding RL, Refat MA, et al. Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. Sci Transl Med. 2018. https:\/\/doi.org\/10.1126\/scitranslmed.aam7710.","journal-title":"Sci Transl Med"},{"key":"422_CR124","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172942","author":"M Mensink","year":"2024","unstructured":"Mensink M, Verleng LJ, Schrama E, Janssen GM, Tjokrodirijo RT, van Veelen PA, et al. Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation. JCI Insight. 2024. https:\/\/doi.org\/10.1172\/jci.insight.172942.","journal-title":"JCI Insight"},{"issue":"7","key":"422_CR125","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.immuni.2024.05.023","volume":"57","author":"OT Burton","year":"2024","unstructured":"Burton OT, Bricard O, Tareen S, Gergelits V, Andrews S, Biggins L, et al. The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. Immunity. 2024;57(7):1586-1602 e1510.","journal-title":"Immunity"}],"container-title":["Inflammation and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41232-026-00422-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41232-026-00422-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41232-026-00422-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:02:30Z","timestamp":1779264150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s41232-026-00422-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":125,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["422"],"URL":"https:\/\/doi.org\/10.1186\/s41232-026-00422-8","relation":{},"ISSN":["1880-8190"],"issn-type":[{"value":"1880-8190","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"16 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}