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The data collected is anonymous data, i.e., the identity of the person to whom the data are referred to was unknown. The patient samples are collected within the context of the diagnostic workup at the discretion of the attending physician and no specific guidelines or recommendations are in force because of the study.The study was approved by the Institutional Review Board of the Centro Acad\u00e9mico de Medicina de Lisboa (240\/22). Since these were considered surveillance activities they were exempt from informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JM-C received research grants administered through his university and received honoraria for serving on the speakers bureaus of Pfizer and Merck Sharp and Dohme. MR received honoraria for serving on the speakers bureau of Pfizer and Merck Sharp and Dohme, for serving in expert panels of Merck Sharp and Dohme, support for attending meetings from Pfizer, and received research grants administered through his university from Merck Sharp and Dohme. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26"}}