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To be able to quantify symptoms in HypoPT patients, we recently developed a disease-specific questionnaire, the Hypoparathyroidism Patient Questionnaire with 28 items (HPQ28). The aim of this study was to find normative values for the HPQ28 in the German general population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We tasked an independent market and social research institute to obtain sociodemographic data and HPQ28 results from a representative sample of the German general population. The HPQ28 comprises five scales and three single items. The five scales indicate different areas of complaints: Pain and cramps (PaC) including five items, neurovegetative symptoms (NVS) including five items, loss of vitality (LoV) including six items, depression and anxiety (DaA) including five items, gastro-intestinal symptoms (GiS) including two items and two control items for depression. Three items were not attributable to any of the five scales: numbness and tingling in certain parts of the body (NT), troubled memory (TM), and racing heart (RH).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Mean age (\u00b1\u2009standard deviation) in the representative general population sample (<jats:italic>n<\/jats:italic>\u2009=\u20092506) was 49.5\u2009\u00b1\u200917.8 years, 51% were female. All scales and single items were affected by gender with women presenting significantly more complaints on every scale and single item in comparison to men (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, Mann-Whitney U test). In addition, all scales and single items, except for GiS, were affected by age in males and females (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Spearman\u2019s correlation). Regression analyses proved a linear trend in the different scores regarding age and gender (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 except for age on the GiS scale).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We present data from the first application of the HPQ28 in a representative sample of the German general population. Almost all scales and single item of the HPQ28 were dependent on age and gender, with older individuals and females presenting a higher burden of complaints.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>DRKS, DRKS00027581. Registered 17th of January 2022, https\/\/drks.de\/search\/de\/trial\/DRKS00027581.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s41687-025-00868-3","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:14:57Z","timestamp":1743758097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Normative values for the hypoparathyroidism patient questionnaire (HPQ28) in the German general population"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-4554","authenticated-orcid":false,"given":"Christian","family":"Trummer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-2591","authenticated-orcid":false,"given":"Martina","family":"Blaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Quint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4540-4506","authenticated-orcid":false,"given":"Maxi","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-7045","authenticated-orcid":false,"given":"Christoph","family":"Herrmann-Lingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-8257","authenticated-orcid":false,"given":"Matthias","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-8625","authenticated-orcid":false,"given":"Heide","family":"Siggelkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"868_CR1","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1210\/clinem\/dgaa113","volume":"105","author":"JP Bilezikian","year":"2020","unstructured":"Bilezikian JP (2020) Hypoparathyroidism. 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