{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:23:27Z","timestamp":1782177807022,"version":"3.54.5"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2628-B-182-007-MY2"],"award-info":[{"award-number":["MOST 105-2628-B-182-007-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["BMRPD37A"],"award-info":[{"award-number":["BMRPD37A"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Patient Rep Outcomes"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Women undergoing treatment for endometrial cancer (EC) often experience climacteric-like symptoms, and some may develop lower limb lymphedema (LLL). LLL can significantly impact women\u2019s quality of life (QoL) and exacerbate climacteric symptoms. In this study, we investigated the prevalence of LLL and explored the differences in climacteric symptoms and QoL between women with and without LLL.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A cross-sectional, observational, and comparative study design was employed. Clinical data for 105 women diagnosed with EC were gathered, encompassing demographic details, LLL, climacteric symptoms, and QoL. Instruments used included a demographic-disease survey, the Gynecological Cancer Lymphedema Questionnaire, the Greene Climacteric Scale, and EORTC QLQ-C30 and QLQ-EN24 questionnaires. Descriptive statistics and independent-sample <jats:italic>t<\/jats:italic>-tests were utilized for data analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this study, 39% of women with EC experienced LLL, with primary symptoms being aching, heaviness, and swelling. Women with LLL also had significantly more severe climacteric symptoms, including anxiety, depression, and vasomotor issues, and they reported poorer physical, role, emotional, cognitive, and social functioning. Additionally, they faced increased fatigue, pain, dyspnea, and more severe specific symptoms like lymphedema, urological and gastrointestinal issues, body image concerns, back\/pelvic pain, and hair loss compared to those without LLL.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The findings of this study enhance understanding of the impact of LLL on climacteric symptoms and QoL in women with EC. Health-care professionals, when advising treatment for EC, should inform women about the likelihood of LLL and assist in early management of its symptoms during and after EC treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s41687-025-00895-0","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:48:35Z","timestamp":1749815315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life and climacteric symptoms in women with endometrial cancer: examining the impact of lower limb lymphedema"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-1301","authenticated-orcid":false,"given":"Chia-Chun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Chang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"issue":"3","key":"895_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"895_CR2","unstructured":"Health Promotion Administration, Ministry of Health and Welfare, Taiwan (2022) Cancer registry annual report, 2020. Accessed 30 Jan 2024. https:\/\/www.hpa.gov.tw\/Pages\/List.aspx?nodeid=119 Accessed 30 Jan 2024"},{"issue":"10333","key":"895_CR3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/s0140-6736(22)00323-3","volume":"399","author":"EJ Crosbie","year":"2022","unstructured":"Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N (2022) Endometrial cancer. Lancet 399(10333):1412\u20131428. https:\/\/doi.org\/10.1016\/s0140-6736(22)00323-3","journal-title":"Lancet"},{"key":"895_CR4","unstructured":"Taiwan Cancer Registry (2021) Long-term trends of age-adjusted incidence rates. https:\/\/twcr.tw\/?page_id=1657 Accessed 30 Jan 2024"},{"key":"895_CR5","unstructured":"Taiwan Cancer Registry (2021) Survival analyses. https:\/\/twcr.tw\/?page_id=1804Accessed 30 Jan 2024"},{"issue":"5","key":"895_CR6","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/gme.0000000000000576","volume":"23","author":"K Matsuo","year":"2016","unstructured":"Matsuo K, Gualtier MR, Cahoon SS et al (2016) Contributing factors for menopausal symptoms after surgical staging for endometrial cancer. Menopause 23(5):535\u2013543. https:\/\/doi.org\/10.1097\/gme.0000000000000576","journal-title":"Menopause"},{"issue":"2","key":"895_CR7","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ygyno.2014.03.003","volume":"133","author":"IJ Rowlands","year":"2014","unstructured":"Rowlands IJ, Beesley VL, Janda M et al (2014) Quality of life of women with lower limb swelling or lymphedema 3\u20135 years following endometrial cancer. Gynecol Oncol 133(2):314\u2013318. https:\/\/doi.org\/10.1016\/j.ygyno.2014.03.003","journal-title":"Gynecol Oncol"},{"issue":"2","key":"895_CR8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ejogrb.2013.07.037","volume":"170","author":"R Angioli","year":"2013","unstructured":"Angioli R, Plotti F, Caf\u00e0 EV et al (2013) Quality of life in patients with endometrial cancer treated with or without systematic lymphadenectomy. Eur J Obstet Gynecol Reprod Biol 170(2):539\u2013543. https:\/\/doi.org\/10.1016\/j.ejogrb.2013.07.037","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"10","key":"895_CR9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3390\/medicina55100668","volume":"55","author":"G Gava","year":"2019","unstructured":"Gava G, Orsili I, Alvisi S, Mancini I, Seracchioli R, Meriggiola MC (2019) Cognition, mood and sleep in menopausal transition: the role of menopausal hormone therapy. Medicina 55(10):668. https:\/\/doi.org\/10.3390\/medicina55100668","journal-title":"Medicina"},{"issue":"3","key":"895_CR10","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ecl.2015.05.003","volume":"44","author":"M Rodriguez","year":"2015","unstructured":"Rodriguez M, Shoupe D (2015) Surgical menopause. Endocrinol Metab Clin North Ame 44(3):531\u2013542. https:\/\/doi.org\/10.1016\/j.ecl.2015.05.003","journal-title":"Endocrinol Metab Clin North Ame"},{"issue":"12","key":"895_CR11","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.jsxm.2022.08.191","volume":"19","author":"A Stuursma","year":"2022","unstructured":"Stuursma A, Lanjouw L, Idema DL, de Bock GH, Mourits MJE (2022) Surgical menopause and bilateral oophorectomy: effect of estrogen-progesterone and testosterone replacement therapy on psychological well-being and sexual functioning a systematic literature review. J Sex Med 19(12):1778\u20131789. https:\/\/doi.org\/10.1016\/j.jsxm.2022.08.191","journal-title":"J Sex Med"},{"key":"895_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jsbmb.2013.08.010","volume":"142","author":"RR Freedman","year":"2014","unstructured":"Freedman RR (2014) Menopausal hot flashes: mechanisms, endocrinology, treatment. J Steroid Biochem Mol Biol 142:115\u2013120. https:\/\/doi.org\/10.1016\/j.jsbmb.2013.08.010","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"895_CR13","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.ygyno.2014.03.015","volume":"133","author":"G Ferrandina","year":"2014","unstructured":"Ferrandina G, Petrillo M, Mantegna G et al (2014) Evaluation of quality of life and emotional distress in endometrial cancer patients: A 2-year prospective, longitudinal study. Gynecol Oncol 133(3):518\u2013525. https:\/\/doi.org\/10.1016\/j.ygyno.2014.03.015","journal-title":"Gynecol Oncol"},{"issue":"2","key":"895_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1525-1438.2007.01020.x","volume":"18","author":"DC Smith","year":"2008","unstructured":"Smith DC, Macdonald OK, Lee CM, Gaffney DK (2008) Survival impact of lymph node dissection in endometrial adenocarcinoma: a surveillance, epidemiology, and end results analysis. Int J Gynecol Cancer 18(2):255\u2013261. https:\/\/doi.org\/10.1111\/j.1525-1438.2007.01020.x","journal-title":"Int J Gynecol Cancer"},{"issue":"10","key":"895_CR15","doi-asserted-by":"publisher","first-page":"CD007585","DOI":"10.1002\/14651858.cd007585.pub4","volume":"10","author":"JA Frost","year":"2017","unstructured":"Frost JA, Webster KE, Bryant A, Morrison J (2017) Lymphadenectomy for the management of endometrial cancer (Review). Cochrane Database Syst Rev 10(10):CD007585. https:\/\/doi.org\/10.1002\/14651858.cd007585.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"895_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ejogrb.2017.02.021","volume":"211","author":"E Lindqvist","year":"2017","unstructured":"Lindqvist E, Wedin M, Fredrikson M, Kj\u00f8lhede P (2017) Lymphedema after treatment for endometrial cancer: a review of prevalence and risk factors. Eur J Obstet Gynecol Reprod Biol 211:112\u2013121. https:\/\/doi.org\/10.1016\/j.ejogrb.2017.02.021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"895_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1188\/03.onf.417-423","volume":"30","author":"M Ryan","year":"2003","unstructured":"Ryan M, Stainton MC, Jaconelli C, Watts S, MacKenzie P, Mansberg T (2003) The experience of lower limb lymphedema for women after treatment for gynecologic cancer. Oncol Nurs Forum 30(3):417\u2013423. https:\/\/doi.org\/10.1188\/03.onf.417-423","journal-title":"Oncol Nurs Forum"},{"key":"895_CR18","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1136\/ijgc-2022-004069","volume":"33","author":"A Datta","year":"2023","unstructured":"Datta A, Ram TS, Karuppusami R et al (2023) A longitudinal study of sexual health and quality of life in endometrial carcinoma survivors. Int J Gynecol Cancer 33:890\u2013896. https:\/\/doi.org\/10.1136\/ijgc-2022-004069","journal-title":"Int J Gynecol Cancer"},{"key":"895_CR19","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1136\/ijgc-2023-004423","volume":"33","author":"G Dinoi","year":"2023","unstructured":"Dinoi G, Multinu F, Yost K et al (2023) Impact of comorbidities and extent of lymphadenectomy on quality of life in endometrial cancer patients treated with minimally invasive surgery in the era of Sentinel lymph nodes. Int J Gynecol Cancer 33:1227\u20131236. https:\/\/doi.org\/10.1136\/ijgc-2023-004423","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"895_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11764-012-0247-5","volume":"7","author":"AL Pusic","year":"2013","unstructured":"Pusic AL, Cemal Y, Albornoz C et al (2013) Quality of life among breast cancer patients with lymphedema: a systematic review of patient-reported outcome instruments and outcomes. J Cancer Surviv 7(1):83\u201392. https:\/\/doi.org\/10.1007\/s11764-012-0247-5","journal-title":"J Cancer Surviv"},{"issue":"5","key":"895_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European organization for research and treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u2013376. https:\/\/doi.org\/10.1093\/jnci\/85.5.365","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"895_CR22","doi-asserted-by":"publisher","first-page":"e12639","DOI":"10.1111\/ecc.12639","volume":"27","author":"M Stukan","year":"2017","unstructured":"Stukan M, Zalewski K, Mardas M et al (2017) Independent psychometric validation of European organization for research and treatment of Cancer quality of life Questionnaire-Endometrial Cancer module (EORTC QLQ-EN24). Eur J Cancer Care 27(1):e12639. https:\/\/doi.org\/10.1111\/ecc.12639","journal-title":"Eur J Cancer Care"},{"issue":"2","key":"895_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ygyno.2010.01.022","volume":"117","author":"J Carter","year":"2010","unstructured":"Carter J, Raviv L, Appollo K, Baser RE, Iasonos A, Barakat RR (2010) A pilot study using the gynecologic Cancer lymphedema questionnaire (GCLQ) as a clinical care tool to identify lower extremity lymphedema in gynecologic cancer survivors. Gynecol Oncol 117(2):317\u2013323. https:\/\/doi.org\/10.1016\/j.ygyno.2010.01.022","journal-title":"Gynecol Oncol"},{"issue":"1","key":"895_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0378-5122(98)00025-5","volume":"29","author":"JG Greene","year":"1998","unstructured":"Greene JG (1998) Constructing a standard climacteric scale. Maturitas 29(1):25\u201331. https:\/\/doi.org\/10.1016\/s0378-5122(98)00025-5","journal-title":"Maturitas"},{"issue":"2","key":"895_CR25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ejca.2010.08.014","volume":"47","author":"E Greimel","year":"2011","unstructured":"Greimel E, Nordin A, Lanceley A et al (2011) Psychometric validation of the European organisation for research and treatment of Cancer quality of life Questionnaire-Endometrial Cancer module (EORTC QLQ-EN24). Eur J Cancer 47(2):183\u2013190. https:\/\/doi.org\/10.1016\/j.ejca.2010.08.014","journal-title":"Eur J Cancer"},{"key":"895_CR26","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1158\/1055-9965.epi-12-0740","volume":"21","author":"KE Weaver","year":"2012","unstructured":"Weaver KE, Forsythe LP, Reeve BB et al (2012) Mental and physical health-related quality of life among U.S. cancer survivors: population estimates from the 2010 National health interview survey. Cancer Epidemiol Biomarkers Prev 21:2108\u20132117. https:\/\/doi.org\/10.1158\/1055-9965.epi-12-0740","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"895_CR27","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s10552-023-01838-0","volume":"35","author":"JA Brown","year":"2024","unstructured":"Brown JA, Olshan AF, Bae-Jump VL, Ogunleye AA, Smith S, Black-Grant S, Nichols HB (2024) Lymphedema self-assessment among endometrial cancer survivors. Cancer Causes Control 35(5):771\u2013785. https:\/\/doi.org\/10.1007\/s10552-023-01838-0","journal-title":"Cancer Causes Control"},{"key":"895_CR28","doi-asserted-by":"publisher","first-page":"1392824","DOI":"10.3389\/fbioe.2024.1392824","volume":"12","author":"J Wang","year":"2024","unstructured":"Wang J, Ma J, Zhang Y et al (2024) The rehabilitation efficacy of diaphragmatic breathing combined with limb coordination training for lower limb lymphedema following gynecologic cancer surgery. Front Bioeng Biotechnol 12:1392824. https:\/\/doi.org\/10.3389\/fbioe.2024.1392824","journal-title":"Front Bioeng Biotechnol"},{"key":"895_CR29","first-page":"166","volume":"10","author":"MS Fang","year":"2006","unstructured":"Fang MS, Yang MS, Tsai EM (2006) Menopausal symptoms of urban aboriginal women in Taiwan. Formos J Med 10:166\u2013174","journal-title":"Formos J Med"},{"issue":"5","key":"895_CR30","first-page":"45","volume":"51","author":"H-C Pai","year":"2004","unstructured":"Pai H-C, Lee S, Tseng Y-H (2004) A correlative study of the uncertainty in the climacteric women. JN 51(5):45\u201352","journal-title":"JN"},{"issue":"12","key":"895_CR31","doi-asserted-by":"publisher","first-page":"10243","DOI":"10.1007\/s00520-022-07429-0","volume":"30","author":"SL Edmed","year":"2022","unstructured":"Edmed SL, Huda MM, Smith SS et al (2022) Sleep and health-related quality of life in women following a cancer diagnosis: results from the women\u2019s wellness after cancer program in Australia. Support Care Cancer 30(12):10243\u201310253. https:\/\/doi.org\/10.1007\/s00520-022-07429-0","journal-title":"Support Care Cancer"},{"issue":"5","key":"895_CR32","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.1007\/s00520-021-06540-y","volume":"30","author":"Y-C Chang","year":"2022","unstructured":"Chang Y-C, Lin G-M, Yeh T-L et al (2022) Impact of mindfulness-based stress reduction on female sexual function and mental health in patients with breast cancer. Support Care Cancer 30(5):4315\u20134325. https:\/\/doi.org\/10.1007\/s00520-021-06540-y","journal-title":"Support Care Cancer"},{"issue":"1","key":"895_CR33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.6224\/jn.202002_67(1).07","volume":"67","author":"J Tsai","year":"2020","unstructured":"Tsai J, Chung Y-C, Chen F-P, Yeh M-L (2020) Effect of aromatherapy on menopausal symptoms, heart rate variability, and sleep quality in women. JN 67(1):44\u201354. https:\/\/doi.org\/10.6224\/jn.202002_67(1).07","journal-title":"JN"},{"key":"895_CR34","unstructured":"EORTC Quality of Life (1995) Quality of life of cancer patients. https:\/\/qol.eortc.org\/questionnaire\/eortc-qlq-c30\/ Accessed 30 Jan 2024"},{"issue":"7","key":"895_CR35","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/pon.727","volume":"12","author":"W-C Chie","year":"2003","unstructured":"Chie W-C, Chang K-J, Huang C-S, Kuo W-H (2003) Quality of life of breast cancer patients in Taiwan: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-BR23. Psychooncology 12(7):729\u2013735. https:\/\/doi.org\/10.1002\/pon.727","journal-title":"Psychooncology"},{"issue":"10","key":"895_CR36","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s11136-017-1619-0","volume":"26","author":"C-C Li","year":"2017","unstructured":"Li C-C, Chang T-C, Tsai Y-F, Chen L (2017) Quality of life among survivors of early-stage cervical cancer in Taiwan: an exploration of treatment modality differences. Qual Life Res 26(10):2773\u20132782. https:\/\/doi.org\/10.1007\/s11136-017-1619-0","journal-title":"Qual Life Res"},{"key":"895_CR37","unstructured":"Health Promotion Administration, Ministry of Health and Welfare, Taiwan (2023) General fitness standards for adults. https:\/\/www.hpa.gov.tw\/Pages\/Detail.aspx?nodeid=542&pid=9737 Accessed 11 Sep 2024"},{"key":"895_CR38","volume-title":"Statistical methods for health care research","author":"BH Munro","year":"2005","unstructured":"Munro BH (2005) T tests: measuring the differences between group means. In: Munro BH (ed) Statistical methods for health care research, 5th edn. Lippincott Williams & Wilkins, Philadelphia","edition":"5"},{"key":"895_CR39","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1245\/s10434-015-4613-1","volume":"23","author":"SH Bae","year":"2016","unstructured":"Bae SH, Lim MC, Lee JS et al (2016) Postoperative lower extremity edema in patients with primary endometrial cancer. Ann Surg Oncol 23:186\u2013195. https:\/\/doi.org\/10.1245\/s10434-015-4613-1","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"895_CR40","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/01443615.2020.1787969","volume":"41","author":"V Karata\u015fl\u0131","year":"2021","unstructured":"Karata\u015fl\u0131 V, Can B, \u00c7ak\u0131r \u0130 et al (2021) Life quality of endometrioid endometrial cancer survivors: a cross-sectional study. J Obstet Gynaecol 41(4):621\u2013625. https:\/\/doi.org\/10.1080\/01443615.2020.1787969","journal-title":"J Obstet Gynaecol"},{"issue":"3","key":"895_CR41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/1471-0528.16870","volume":"129","author":"M Wedin","year":"2021","unstructured":"Wedin M, Stalberg K, Marcickiewicz J et al (2021) Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer: a prospective longitudinal multicentre study. BJOG 129(3):50\u2013460. https:\/\/doi.org\/10.1111\/1471-0528.16870","journal-title":"BJOG"},{"issue":"1","key":"895_CR42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ygyno.2010.11.024","volume":"121","author":"M Becker","year":"2011","unstructured":"Becker M, Malafy T, Bossart M, Henne K, Gitsch G, Denschlag D (2011) Quality of life and sexual functioning in endometrial cancer survivors. Gynecol Oncol 121(1):169\u2013173. https:\/\/doi.org\/10.1016\/j.ygyno.2010.11.024","journal-title":"Gynecol Oncol"},{"issue":"2","key":"895_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.12788\/jcso.0109","volume":"13","author":"I Kusters","year":"2015","unstructured":"Kusters I, Williams M, Obermair A, Janda M (2015) Women with self-reported lower limb lymphedema after treatment for gynecological cancers: are they more likely to self-report psychosocial symptoms and less likely to use services? J Community Support Oncol 13(2):55\u201361. https:\/\/doi.org\/10.12788\/jcso.0109","journal-title":"J Community Support Oncol"},{"issue":"2","key":"895_CR44","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11764-015-0472-9","volume":"10","author":"SN Westin","year":"2016","unstructured":"Westin SN, Sun CC, Tung CS et al (2016) Survivors of gynecologic malignancies: impact of treatment on health and well-being. J Cancer Surviv 10(2):261\u2013270. https:\/\/doi.org\/10.1007\/s11764-015-0472-9","journal-title":"J Cancer Surviv"},{"issue":"7","key":"895_CR45","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.ejca.2005.11.026","volume":"42","author":"G Prue","year":"2006","unstructured":"Prue G, Rankin J, Allen J, Gracey J, Cramp F (2006) Cancer-related fatigue: a critical appraisal. Eur J Cancer 42(7):846\u2013863. https:\/\/doi.org\/10.1016\/j.ejca.2005.11.026","journal-title":"Eur J Cancer"},{"issue":"3","key":"895_CR46","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1200\/jco.2001.19.3.895","volume":"19","author":"J Savard","year":"2001","unstructured":"Savard J, Morin CM (2001) Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol 19(3):895\u2013908. https:\/\/doi.org\/10.1200\/jco.2001.19.3.895","journal-title":"J Clin Oncol"},{"issue":"7\u20138","key":"895_CR47","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/jocn.15189","volume":"29","author":"C-H Yu","year":"2020","unstructured":"Yu C-H, Wang T-J, Chang C-L et al (2020) Healthy lifestyles, sleep and fatigue in endometrial cancer survivors: a cross-sectional study. J Clin Nurs 29(7\u20138):1372\u20131380. https:\/\/doi.org\/10.1111\/jocn.15189","journal-title":"J Clin Nurs"},{"issue":"1","key":"895_CR48","doi-asserted-by":"publisher","first-page":"100153","DOI":"10.1016\/j.apjon.2022.100153","volume":"10","author":"Y-Y Hsu","year":"2022","unstructured":"Hsu Y-Y, Liu C-Y, Ho C-L, Hsu K-F (2022) Determinants of quality of life related to lower limb lymphedema in women with gynecological cancer surgery. Asia Pac J Oncol Nurs 10(1):100153. https:\/\/doi.org\/10.1016\/j.apjon.2022.100153","journal-title":"Asia Pac J Oncol Nurs"},{"issue":"3","key":"895_CR49","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1586\/erp.11.30","volume":"11","author":"A Finnane","year":"2011","unstructured":"Finnane A, Hayes SC, Obermair A, Janda M (2011) Quality of life of women with lower-limb lymphedema following gynecological cancer. Expert Rev Pharmacoecon Outcomes Res 11(3):287\u2013297. https:\/\/doi.org\/10.1586\/erp.11.30","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"issue":"11","key":"895_CR50","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1007\/s00520-013-1879-3","volume":"21","author":"G Dunberger","year":"2013","unstructured":"Dunberger G, Lindquist H, Waldenstr\u00f6m A-C, Nyberg T, Steineck G, \u00c5vall-Lundqvist E (2013) Lower limb lymphedema in gynecological cancer survivors: effect on daily life functioning. Support Care Cancer 21(11):3063\u20133070. https:\/\/doi.org\/10.1007\/s00520-013-1879-3","journal-title":"Support Care Cancer"},{"issue":"1","key":"895_CR51","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/jsm.12764","volume":"12","author":"L Aerts","year":"2015","unstructured":"Aerts L, Enzlin P, Verhaeghe J, Poppe W, Vergote I, Amant F (2015) Sexual functioning in women after surgical treatment for endometrial cancer: a prospective controlled study. J Sex Med 12(1):198\u2013209. https:\/\/doi.org\/10.1111\/jsm.12764","journal-title":"J Sex Med"},{"issue":"1","key":"895_CR52","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.ygyno.2012.12.041","volume":"129","author":"CS Oldenburg","year":"2013","unstructured":"Oldenburg CS, Boll D, Nicolaije KAH et al (2013) The relationship of body mass index with quality of life among endometrial cancer survivors: a study from the population-based PROFILES registry. Gynecol Oncol 129(1):216\u2013221. https:\/\/doi.org\/10.1016\/j.ygyno.2012.12.041","journal-title":"Gynecol Oncol"}],"container-title":["Journal of Patient-Reported Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41687-025-00895-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41687-025-00895-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41687-025-00895-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:48:39Z","timestamp":1749815319000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpro.springeropen.com\/articles\/10.1186\/s41687-025-00895-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["895"],"URL":"https:\/\/doi.org\/10.1186\/s41687-025-00895-0","relation":{},"ISSN":["2509-8020"],"issn-type":[{"value":"2509-8020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]},"assertion":[{"value":"31 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles outlined in the Declaration of the Institutional Review Board of Chang Gung Medical Foundation (Date: 05\/16\/2016\/No. 201600229B0). Informed consent was obtained from all individual participants who were included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not application.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"66"}}