{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:47:28Z","timestamp":1791254848655,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Patient Rep Outcomes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comprehensive research on the specific factors affecting the quality of life (QOL) of patients with colorectal cancer (CRC) is lacking. We investigated patient factors affecting QOL in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study at Dr. Suliman Fakeeh Hospital, a private tertiary center in Jeddah City, KSA. We used the validated Arabic versions of the Cancer Quality of Life Questionnaire-30 (QLQ-30) and Colorectal Cancer Quality of Life Questionnaire-29 (QLQ-CR29) in patients with CRC. We used a generalized linear model to analyze the data. Significant linear correlations between functional and symptom scores and 11 factors, including age, sex, tumor site and stage, comorbidities, surgery type\/approach, leaks, stoma, and neoadjuvant or adjuvant therapy, were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 104 participants answered the survey. The mean global health score was 72.43 (95% confidence interval [CI] 68.18\u201376.52). Cognitive and physical function scored highest and lowest on the QLQ-30, with a mean of 76.92 (95% CI 71.47\u201381.73) and 24.92 (95% CI 65.57\u201374.61), respectively. The worst symptom was insomnia, with a mean of 42.30 (95% CI 36.21\u201348.71). The most distressing symptoms on the QLQ-CR29 were stoma embarrassment and bloating, with a mean of 41.34 (95% CI 24.67\u201358.01). Tumor stage and stoma were the two most significant factors for predicting poor QOL. The factors influencing impotence and male libido included age, tumor stage, comorbidities, and the use of chemoradiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A one-unit increase in tumor stage was correlated with a 4.88-unit decrease in the global health status score, whereas a stoma was linked to a 22-fold reduction in social function scores. Advanced tumor stage and the presence of a stoma significantly affected patients\u2019 functional status and symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41687-025-00971-5","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:29:40Z","timestamp":1764073780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of impaired quality of life among colorectal cancer survivors: a cross-sectional study"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-7229","authenticated-orcid":false,"given":"Abdulrahman","family":"Alotaibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Hahn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atyaf","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essa","family":"Alazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Musslem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaaeldin","family":"Darewish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Eltaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakher","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamel","family":"Soaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"971_CR1","unstructured":"Cancer Incidence Report (2020). https:\/\/shc.gov.sa"},{"key":"971_CR2","unstructured":"National Cancer Institute. http:\/\/www.cancer.gov\/about-cancer\/coping\/survivorship"},{"key":"971_CR3","unstructured":"Living with or beyond cancer macmillan cancer support. Archived from the original on 16 July 2011. Accessed 30 Nov 2010."},{"key":"971_CR4","unstructured":"Office of Cancer Survivorship Statistics (2023) graphs and definitions. https:\/\/cancercontrol.cancer.gov\/ocs\/statistics. Accessed 11 May"},{"key":"971_CR5","first-page":"2324","volume":"9","author":"LT Tau","year":"2011","unstructured":"Tau LT, Chan SW (2011) Exploring the quality of life and the impact of the disease among patients with colorectal cancer: a systematic review. JBI Libr Syst Rev 9:2324\u20132378","journal-title":"JBI Libr Syst Rev"},{"key":"971_CR6","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1111\/j.1572-0241.2002.05694.x","volume":"97","author":"SD Ramsey","year":"2002","unstructured":"Ramsey SD, Berry K, Moinpour C, Giedzinska A, Andersen MR (2002) Quality of life in long term survivors of colorectal cancer. Am J Gastroenterol 97:1228\u20131234","journal-title":"Am J Gastroenterol"},{"key":"971_CR7","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.4172\/2329-6771.1000151","volume":"4","author":"S AlOtaibi","year":"2015","unstructured":"AlOtaibi S, AlAbbas F, Bashnini N, Almoshadq A, Al-Hindi H, Pasha M (2015) Functional assessment of quality of life using EORTC QLQ-CR29 in patients with colon cancer at King Abdulaziz university hospital. J Integr Oncol 4:2329\u20136771","journal-title":"J Integr Oncol"},{"key":"971_CR8","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12094-015-1346-3","volume":"18","author":"KM Almutairi","year":"2016","unstructured":"Almutairi KM, Alhelih E, Al-Ajlan AS, Vinluan JM (2016) A cross-sectional assessment of quality of life of colorectal cancer patients in Saudi Arabia. Clin Transl Oncol 18:144\u2013152","journal-title":"Clin Transl Oncol"},{"key":"971_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s13187-015-0839-7","volume":"31","author":"FF Alabbas","year":"2016","unstructured":"Alabbas FF, Al-Otaibi SM, Pasha MH, Alghamdi AM, Al-Hindi HM, Al-Ahwal MS, El-Deek BS (2016) Impact of physiological symptoms and complications of colorectal cancer on the quality of life of patients at King Abdulaziz university hospital. J Cancer Educ 31:221\u2013227","journal-title":"J Cancer Educ"},{"key":"971_CR10","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.31557\/APJCP.2022.23.4.1301","volume":"23","author":"M Abu-Helalah","year":"2022","unstructured":"Abu-Helalah M, Mustafa H, Alshraideh H, Alsuhail AI, Al-Abdallah OAA, Al Olayan R A (2022) Quality of life and psychological wellbeing of colorectal cancer survivors in the KSA. Asian Pac J Cancer Prev 23:1301\u20131308","journal-title":"Asian Pac J Cancer Prev"},{"key":"971_CR11","doi-asserted-by":"crossref","unstructured":"Qedair JT, Al Qurashi AA, Alamoudi S, Aga SS, A YH (2022) Assessment of quality of life (QoL) of colorectal cancer patients using QLQ-30 and QLQ-CR 29 at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Int J Surg Oncol 2022:4745631","DOI":"10.1155\/2022\/4745631"},{"key":"971_CR12","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC, Kaasa S (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365\u2013376","journal-title":"J Natl Cancer Inst"},{"key":"971_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1196\/annals.1414.021","volume":"1138","author":"MA Awad","year":"2008","unstructured":"Awad MA, Denic S, El Taji H (2008) Validation of the European organization for research and treatment of cancer quality of life questionnaires for Arabic-speaking populations. Ann N Y Acad Sci 1138:146\u2013154","journal-title":"Ann N Y Acad Sci"},{"key":"971_CR14","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s11136-011-0067-5","volume":"21","author":"SK Chambers","year":"2012","unstructured":"Chambers SK, Meng X, Youl P, Aitken J, Dunn J, Baade P (2012) A five-year prospective study of quality of life after colorectal cancer. Qual Life Res 21:1551\u20131564","journal-title":"Qual Life Res"},{"key":"971_CR15","doi-asserted-by":"publisher","first-page":"1098176","DOI":"10.3389\/fpsyt.2023.1098176","volume":"14","author":"MA AlJaffar","year":"2023","unstructured":"AlJaffar MA, Enani SS, Almadani AH, Albuqami FH, Alsaleh KA, Alosaimi FD (2023) Determinants of quality of life of cancer patients at a tertiary care medical City in Riyadh, Saudi Arabia. Front Psychiatry 14:1098176","journal-title":"Front Psychiatry"},{"key":"971_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1477-7525-11-46","volume":"11","author":"J Dunn","year":"2013","unstructured":"Dunn J, Ng SK, Breitbart W, Aitken J, Youl P, Baade PD, Chambers SK (2013) Health-related quality of life and life satisfaction in colorectal cancer survivors: trajectories of adjustment. Health Qual Life Outcomes 11:46","journal-title":"Health Qual Life Outcomes"},{"key":"971_CR17","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1002\/pon.3288","volume":"22","author":"T LeMasters","year":"2013","unstructured":"LeMasters T, Madhavan S, Sambamoorthi U, Kurian S (2013) A population-based study comparing HRQoL among breast, prostate, and colorectal cancer survivors to propensity score matched controls, by cancer type, and gender. Psychooncology 22:2270\u20132282","journal-title":"Psychooncology"},{"key":"971_CR18","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s11764-020-00901-y","volume":"14","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Joshy G, Glass K, Banks E (2020) Physical functional limitations and psychological distress in people with and without colorectal cancer: findings from a large Australian study. J Cancer Surviv 14:894\u2013905","journal-title":"J Cancer Surviv"},{"key":"971_CR19","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s11764-014-0422-y","volume":"9","author":"L Russell","year":"2015","unstructured":"Russell L, Gough K, Drosdowsky A, Schofield P, Aranda S, Butow PN, Westwood JA, Krishnasamy M, Young JM, Phipps-Nelson J, King D, Jefford M (2015) Psychological distress, quality of life, symptoms and unmet needs of colorectal cancer survivors near the end of treatment. J Cancer Surviv 9:462\u2013470","journal-title":"J Cancer Surviv"},{"key":"971_CR20","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3390\/cancers14061527","volume":"14","author":"M Legg","year":"2022","unstructured":"Legg M, Meertens RM, van Roekel E, Breukink SO, Janssen ML, Keulen ETP, Steindorf K, Weijenberg MP, Bours M (2022) The association between sleep quality and fatigue in colorectal cancer survivors up until two years after treatment: a cross-sectional and longitudinal analysis. Cancers (Basel) 14:1527","journal-title":"Cancers (Basel)"},{"key":"971_CR21","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/pon.4595","volume":"27","author":"T Coles","year":"2018","unstructured":"Coles T, Tan X, Bennett AV, Sanoff HK, Basch E, Jensen RE, Reeve BB (2018) Sleep quality in individuals diagnosed with colorectal cancer: factors associated with sleep disturbance as patients transition off treatment. Psychooncology 27:1050\u20131056","journal-title":"Psychooncology"},{"key":"971_CR22","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.3390\/cancers13112578","volume":"13","author":"M Ton","year":"2021","unstructured":"Ton M, Watson NF, Sillah A, Malen RC, Labadie JD, Reedy AM, Cohen SA, Burnett-Hartman AN, Newcomb PA, Phipps AI (2021) Colorectal cancer anatomical site and sleep quality. Cancers (Basel) 13:2578","journal-title":"Cancers (Basel)"},{"key":"971_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/annonc\/mdr133","volume":"23","author":"MJ Traa","year":"2012","unstructured":"Traa MJ, De Vries J, Roukema JA, Den Oudsten BL (2012) Sexual (dys)function and the quality of sexual life in patients with colorectal cancer: a systematic review. Ann Oncol 23:19\u201327","journal-title":"Ann Oncol"},{"key":"971_CR24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3390\/diseases12040066","volume":"12","author":"CVI Feier","year":"2024","unstructured":"Feier CVI, Paunescu IA, Faur AM, Cozma GV, Blidari AR, Muntean C (2024) Sexual functioning and impact on quality of life in patients with early-onset colorectal cancer: a systematic review. Diseases 12:66","journal-title":"Diseases"},{"key":"971_CR25","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/pon.5352","volume":"29","author":"L Song","year":"2020","unstructured":"Song L, Han X, Zhang J, Tang L (2020) Body image mediates the effect of stoma status on psychological distress and quality of life in patients with colorectal cancer. Psychooncology 29:796\u2013802","journal-title":"Psychooncology"},{"key":"971_CR26","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.ijrobp.2018.12.005","volume":"103","author":"A Downing","year":"2019","unstructured":"Downing A, Glaser AW, Finan PJ, Wright P, Thomas JD, Gilbert A, Corner J, Richards M, Morris EJA, Sebag-Montefiore D (2019) Functional outcomes and health-related quality of life after curative treatment for rectal cancer: a population-level study in England. Int J Radiat Oncol Biol Phys 103:1132\u20131142","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"971_CR27","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.ejso.2018.03.025","volume":"44","author":"L Trenti","year":"2018","unstructured":"Trenti L, Galvez A, Biondo S, Solis A, Vallribera-Valls F, Espin-Basany E, Garcia-Granero A, Kreisler E (2018) Quality of life and anterior resection syndrome after surgery for mid to low rectal cancer: a cross-sectional study. Eur J Surg Oncol 44:1031\u20131039","journal-title":"Eur J Surg Oncol"},{"key":"971_CR28","doi-asserted-by":"publisher","first-page":"zrad030","DOI":"10.1093\/bjsopen\/zrad030","volume":"7","author":"O Waddell","year":"2023","unstructured":"Waddell O, McLauchlan J, McCombie A, Glyn T, Frizelle F (2023) Quality of life in early-onset colorectal cancer patients: systematic review. BJS Open 7:zrad030","journal-title":"BJS Open"},{"key":"971_CR29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11912-019-0830-2","volume":"21","author":"E Lapinsky","year":"2019","unstructured":"Lapinsky E, Man LC, MacKenzie AR (2019) Health-related quality of life in older adults with colorectal cancer. Curr Oncol Rep 21:81","journal-title":"Curr Oncol Rep"},{"key":"971_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1210\/er.2001-0016","volume":"24","author":"BB Sherwin","year":"2003","unstructured":"Sherwin BB (2003) Estrogen and cognitive functioning in women. Endocr Rev 24:133\u2013151","journal-title":"Endocr Rev"},{"key":"971_CR31","doi-asserted-by":"publisher","first-page":"453","DOI":"10.21037\/jgo.2019.02.04","volume":"10","author":"D Laghousi","year":"2019","unstructured":"Laghousi D, Jafari E, Nikbakht H, Nasiri B, Shamshirgaran M, Aminisani N (2019) Gender differences in health-related quality of life among patients with colorectal cancer. J Gastrointest Oncol 10:453\u2013461","journal-title":"J Gastrointest Oncol"},{"key":"971_CR32","doi-asserted-by":"publisher","first-page":"e0156534","DOI":"10.1371\/journal.pone.0156534","volume":"11","author":"SV Adams","year":"2016","unstructured":"Adams SV, Ceballos R, Newcomb PA (2016) Quality of life and mortality of long-term colorectal cancer survivors in the Seattle colorectal cancer family registry. PLoS ONE 11:e0156534","journal-title":"PLoS ONE"},{"key":"971_CR33","doi-asserted-by":"publisher","first-page":"6211","DOI":"10.3390\/jcm11206211","volume":"11","author":"F \u015awi\u0105tkowski","year":"2022","unstructured":"\u015awi\u0105tkowski F, G\u00f3rnicki T, Bu\u0142dy\u015b K, Chabowski M (2022) The quality of life of patients with surgically treated colorectal cancer: a narrative review. J Clin Med 11:6211","journal-title":"J Clin Med"},{"key":"971_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/diseases12040079","volume":"12","author":"V Braicu","year":"2024","unstructured":"Braicu V, Stelian P, Fulger L, Verdes G, Brebu D, Duta C, Fizedean C, Ignuta F, Danila AI, Cozma GV (2024) Impact of systemic treatments on outcomes and quality of life in patients with RAS-positive stage IV colorectal cancer: a systematic review. Diseases 12:79","journal-title":"Diseases"},{"key":"971_CR35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11136-004-0729-7","volume":"14","author":"KT Ashing-Giwa","year":"2005","unstructured":"Ashing-Giwa KT (2005) The contextual model of hrqol: a paradigm for expanding the HRQoL framework. Qual Life Res 14:297\u2013307","journal-title":"Qual Life Res"}],"container-title":["Journal of Patient-Reported Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41687-025-00971-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41687-025-00971-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41687-025-00971-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:29:44Z","timestamp":1764073784000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpro.springeropen.com\/articles\/10.1186\/s41687-025-00971-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["971"],"URL":"https:\/\/doi.org\/10.1186\/s41687-025-00971-5","relation":{},"ISSN":["2509-8020"],"issn-type":[{"value":"2509-8020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"1 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board (IRB) of Dr. Suliman Fakeeh Hospital (approval number 367\/IRB\/2022; date of approval September 2022). Written informed consent was obtained from patients before answering the survey.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"136"}}