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However, whether cerebellar irradiation alone (CIA) could induce these disorders is unknown. We investigated the effect of CIA in an animal model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eleven-day-old rat pups underwent a single 3-Gy dose of either WBI (<jats:italic>n<\/jats:italic> = 28) or CIA (<jats:italic>n<\/jats:italic> = 20), while 34 rat pups were sham-irradiated (controls). Cell death was evaluated in the subgranular zone of the hippocampus by counting pyknotic cells after haematoxylin\/eosin staining at 6 h after irradiation for 10, 8, and 9 pups, respectively. Behavioural changes were evaluated via open-field test at 6 weeks for 18, 12, and 25 pups, respectively. Unpaired two-tailed <jats:italic>t<\/jats:italic>-test and one-way and two-way repeated ANOVA were used.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Massive cell death in cerebellar external granular layer was detected at 6 h after CIA (1,419 \u00b1 211 mm, mean \u00b1 S.E.M. <jats:italic>versus<\/jats:italic> controls (68 \u00b1 12 mm) (<jats:italic>p<\/jats:italic> &lt; 0.001)), while no significant difference between CIA (1,419 \u00b1 211 mm) <jats:italic>versus<\/jats:italic> WBI (1,433 \u00b1 107 mm) (<jats:italic>p<\/jats:italic> = 0.955) was found. At open-field behavioural test, running distance, activity, wall distance, middle zone visit times, and duration were higher for WBI <jats:italic>versus<\/jats:italic> controls (<jats:italic>p<\/jats:italic> &lt; 0.010), but no difference between CIA and controls was found (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Although the cerebellum is involved in hyperactivity, fear, and anxiety disorders, CIA did not induce these disorders, indicating that WBI-induced cerebellar injury does not directly cause these behavioural abnormalities after WBI. Thus, targeting the cerebellum alone may not be enough to rescue or reduce these behavioural abnormalities after WBI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41747-022-00307-8","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T01:04:26Z","timestamp":1668474266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebellar irradiation does not cause hyperactivity, fear, and anxiety-related disorders in the juvenile rat brain"],"prefix":"10.1186","volume":"6","author":[{"given":"Yafeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-757X","authenticated-orcid":false,"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"307_CR1","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1007\/s00381-015-2829-9","volume":"31","author":"A Lassaletta","year":"2015","unstructured":"Lassaletta A, Bouffet E, Mabbott D, Kulkarni AV (2015) Functional and neuropsychological late outcomes in posterior fossa tumors in children. 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