{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:31:18Z","timestamp":1788877878191,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol Exp"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Flat detector computed tomography (FDCT) is frequently applied for periinterventional brain imaging within the angiography suite. Novel technical developments such as the Sine Spin FDCT (S-FDCT) may provide an improved cerebral soft tissue contrast. This study investigates the effect of S-FDCT on the differentiation between gray and white matter compared to conventional FDCT (C-FDCT) and multidetector computed tomography (MDCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of a prospectively maintained patient database was performed, including patients who underwent mechanical thrombectomy in our institution and received S-FDCT or C-FDCT as well as MDCT. Differentiation between gray and white matter on the contralateral hemisphere to the ischemic stroke was analyzed quantitatively by contrast-to-noise ratio (CNR) and qualitatively (5-point ordinal scale).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a cohort of 109 patients, MDCT demonstrated the best differentiation between gray and white matter compared to both FDCT techniques (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). Comparing both generations of FDCT, S-FDCT provided better visibility of the basal ganglia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and the supratentorial cortex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) compared to C-FDCT both in quantitative and qualitative analyses. Median CNR were as follows: S-FDCT 2.41 (interquartile range [IQR] 1.66\u20133.21), C-FDCT 0.96 (0.46\u20131.70), MDCT 3.43 (2.83\u20134.17). For basal ganglia, median score and IQR were as follows: S-FDCT 2.00 (2.00\u20133.00), C-FDCT 1.50 (1.00\u20132.00), MDCT 5.00 (4.00\u20135.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The novel S-FDCT improves the periinterventional imaging quality of cerebral soft tissue compared to C-FDCT. Thus, it may improve the diagnosis of complications within the angiography suite. MDCT provides the best option for x-ray-based imaging of the brain tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance statement<\/jats:title>\n                    <jats:p>Flat detector computed tomography is a promising technique for cerebral soft tissue imaging, while the novel Sine Spin flat detector computed tomography technique improves imaging quality compared to conventional flat detector computed tomography and thus may facilitate periinterventional diagnosis of gray and white matter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\u2022 Flat detector computed tomography (FDCT) is frequently applied for periinterventional brain imaging.<\/jats:p>\n                    <jats:p>\u2022 The potential of novel Sine Spin FDCT (S-FDCT) is unknown so far.<\/jats:p>\n                    <jats:p>\u2022 S-FDCT improves the visibility of cerebral soft tissue compared to conventional FDCT.<\/jats:p>\n                    <jats:p>\u2022 Multidetector computed tomography is superior to both FDCT techniques.<\/jats:p>\n                    <jats:p>\u2022 S-FDCT may facilitate the evaluation of brain parenchyma within the angiography suite.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41747-023-00412-2","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T21:22:16Z","timestamp":1706736136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sine Spin flat detector CT can improve cerebral soft tissue imaging: a retrospective in vivo study"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-5459","authenticated-orcid":false,"given":"Niclas","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Wucherpfennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Jesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Neuberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resul","family":"G\u00fcney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A.","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik F.","family":"Vollherbst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"412_CR1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1136\/neurintsurg-2016-012866","volume":"9","author":"JR Leyhe","year":"2017","unstructured":"Leyhe JR, Tsogkas I, Hesse AC et al (2017) Latest generation of flat detector CT as a peri-interventional diagnostic tool: a comparative study with multidetector CT. 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MB reports board membership: DSMB Vascular Dynamics; consultancy: Roche, Guerbet, Codman; grants\/grants pending: DFG, Hopp Foundation, Novartis, Siemens, Guerbet, Stryker, Covidien; payment for lectures (including service on speaker\u2019s bureaus): Novartis, Roche, Guerbet, Teva, Bayer, Codman. MAM has received consulting fees, speaker fees, and travel support outside this work from Codman, Covidien\/Medtronic, MicroVention, Phenox, and Stryker. DFV has received travel support outside this work from MicroVention, Stryker, and Cerenovus. All other authors have nothing to disclose in regard to this work.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"5"}}