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Clark Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol Exp"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The human placenta is critical in supporting fetal development, and placental dysfunction may compromise maternal-fetal health. Early detection of placental dysfunction remains challenging due to the lack of reliable biomarkers. This study compares placental quantitative susceptibility mapping and T2* values between healthy and high-risk pregnancies and investigates their association with maternal and fetal parameters and their ability to predict birth weight (BW).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A total of 105 pregnant individuals were included: 68 healthy controls and 37 high-risk due to fetal growth restriction (FGR), chronic or gestational hypertension, and pre-eclampsia. Placental magnetic resonance imaging data were collected using a three-dimensional multi-echo radiofrequency-spoiled gradient-echo, and mean susceptibility and T2* values were calculated. To analyze associations and estimate BW, we employed linear regression and regression forest models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No significant differences were found in susceptibility between high-risk pregnancies and controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.928). T2* values were significantly lower in high-risk pregnancies (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), particularly in pre-eclampsia and FGR, emerging as a predictor of BW. The regression forest model showed placental T2* as a promising mode for BW estimation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our findings underscore the potential of mean placental T2* as a more sensitive marker for detecting placental dysfunction in high-risk pregnancies than mean placental susceptibility. Moreover, the high-risk status emerged as a significant predictor of BW. These results call for further research with larger and more diverse populations to validate these findings and enhance prediction models for improved pregnancy management.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Relevance statement<\/jats:title>\n            <jats:p>This study highlights the potential of placental T2* magnetic resonance imaging measurements as reliable indicators for detecting placental dysfunction in high-risk pregnancies, aiding in improved prenatal care and birth weight prediction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key Points<\/jats:title>\n            <jats:p>\n              <jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>Placental dysfunction in high-risk pregnancies is evaluated using MRI T2* values.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>Lower T2* values significantly correlate with pre-eclampsia and fetal growth restriction.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>T2* MRI may predict birth weight, enhancing prenatal care outcomes.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1186\/s41747-025-00565-2","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T17:06:01Z","timestamp":1739898361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies"],"prefix":"10.1186","volume":"9","author":[{"given":"Morteza","family":"Pishghadam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lylach","family":"Haizler-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius S.","family":"Ngwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Kapse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Limperopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-7898","authenticated-orcid":false,"given":"Nickie N.","family":"Andescavage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"565_CR1","doi-asserted-by":"publisher","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","volume":"370","author":"GJ Burton","year":"2015","unstructured":"Burton GJ, Fowden AL (2015) The placenta: a multifaceted, transient organ. 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