{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:19Z","timestamp":1788876559379,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"FWF","award":["10.55776\/DOC110"],"award-info":[{"award-number":["10.55776\/DOC110"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol Exp"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thermal ablation of hepatocellular carcinoma (HCC) requires an adequate safety margin around the tumor to ensure treatment success. In this retrospective study, we evaluated an artificial intelligence (AI) pipeline for automatic safety margin assessment on computed tomography (CT) scans, with the goal of supporting radiologists in taking immediate clinical actions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We included CT scans from patients with primary liver cancer treated at the local university hospital with radiofrequency ablation (RFA) between 2010 and 2022. The study group consisted of 43 randomly picked lesions with local tumor progression, with an average diameter of 35\u2009mm [24\u201345] (median [interquartile range]). For comparison, we randomly selected 96 lesions showing no local tumor progression\n                      <jats:italic>via<\/jats:italic>\n                      propensity matching (diameter 28\u2009mm [17\u201337]). To calculate the minimum ablative margin (MAM), we coregistered the intraprocedural patient scans with a recently proposed AI-based image registration model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 139 HCC cases were evaluated, with an average follow-up interval of 25 months [8\u201342] (median, interquartile range). The calculated MAM was found to be a significant predictor of local tumor progression (odds ratio 0.42, 95% confidence interval 0.35\u20130.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Significant differences in local tumor protection rate were found between the lesions grouped by MAM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our AI-driven pipeline enabled fast and reliable assessment of the efficacy of RFA of HCC in relation to ablative margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance statement<\/jats:title>\n                    <jats:p>The ablative margins have been automatically quantified using a novel method that combines AI-based segmentation with AI-driven image registration. By delivering robust margin quantification quickly, the proposed pipeline can help clinicians in assessing ablative margins intraoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>An AI-driven tool can rapidly and automatically measure the treatment margin after liver cancer ablation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Inadequate safety margins calculated with the proposed pipeline are associated with a higher risk of local tumor recurrence.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A MAM of 2.50\u2009mm suffices to lower the risk of local tumor progression to below 10%.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41747-026-00781-4","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:31:37Z","timestamp":1788874297000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AI-driven ablative margin assessment after HCC radiofrequency ablation: a case-control feasibility study"],"prefix":"10.1186","volume":"10","author":[{"given":"Stefano","family":"Fogarollo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Laimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Harders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-5792","authenticated-orcid":false,"given":"Reto","family":"Bale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"781_CR1","doi-asserted-by":"publisher","first-page":"S361","DOI":"10.21037\/jgo.2020.02.08","volume":"12","author":"H Samant","year":"2021","unstructured":"Samant H, Amiri HS, Zibari B (2021) Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. 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Written informed consent was obtained from all subjects (patients) in this study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have read and approved the final version of the manuscript. Written informed consent was obtained from all subjects (patients) in this study.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"117"}}