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We aimed to evaluate magnetic resonance elastography (MRE)-based slip interface imaging (SII) to quantify lumbar intermuscular myofascial mobility in healthy volunteers (HV), assessing repeatability, and comparing CLBP-MP patients with matched HV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      MRE\/SII was performed in 20 CLBP-MP patients and 41 HV. SII-derived maximal normalized displacement discontinuity (Dnorm) was analyzed at the quadratus lumborum\u2013erector spinae (QL\u2013ES) and ES\u2013multifidus (ES\u2013M) interfaces at L3\u2013L4, computing mobility indices. Repeatability was assessed\n                      <jats:italic>via<\/jats:italic>\n                      within-subject coefficient of variation (wCV) and Bland\u2013Altman analysis. In HV, associations with age\/sex\/body mass index (BMI) were tested. Group differences were evaluated by comparing patients with matched HV and by stratifying patients by \u201cpain, enjoyment, and general activity\u201d (PEG) score using one-way ANOVA. Associations with PEG were evaluated using Pearson correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Repeatability was excellent (mean wCV\u2009&lt;\u200910% for within- and between-day). In HV, myofascial mobility differed by anatomic interface and vertebral level but showed no association with age, sex, or BMI. At L4 ES\u2013M, mobility showed a significant group effect (F(2,37)\u2009=\u200913.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with lower mobility in moderate-to-severe\n                      <jats:italic>versus<\/jats:italic>\n                      mild pain (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.023) and\n                      <jats:italic>versus<\/jats:italic>\n                      HV (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.001), and correlated negatively with PEG (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pain-related reductions in localized lumbar intermuscular myofascial mobility in CLBP-MP were shown. MRE-based SII is a repeatable quantitative technique, supporting its potential as an early-stage biomarker for characterizing lumbar myofascial mobility and guiding multicenter studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>\n                              <jats:italic>Question<\/jats:italic>\n                            <\/jats:bold>\n                            Lumbar myofascial interface sliding is essential for normal movement, but objective quantification of sliding dysfunction in chronic low back pain remains limited.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>\n                              <jats:italic>Findings<\/jats:italic>\n                            <\/jats:bold>\n                            SII showed high repeatability and reduced L4 erector spinae-multifidus mobility associated with greater pain severity in chronic low back pain patients.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>\n                              <jats:italic>Relevance statement<\/jats:italic>\n                            <\/jats:bold>\n                            MR elastography-based SII offers repeatable, noninvasive measurement of lumbar myofascial mobility and shows pain-related localized restriction in chronic low back pain with myofascial features, supporting objective characterization of inter-muscular myofascial mechanics and exploratory biomarker development.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s41747-026-00812-0","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:55:26Z","timestamp":1790844926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced lumbar myofascial mobility in chronic low back pain quantified using MR elastography-based slip interface imaging"],"prefix":"10.1186","volume":"10","author":[{"given":"Emi","family":"Hojo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Rossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Manduca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garret M.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Nan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Ehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-966X","authenticated-orcid":false,"given":"Ziying","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"812_CR1","doi-asserted-by":"publisher","unstructured":"GBD 2021 Low Back Pain Collaborators (2023) Global, regional, and national burden of low back pain, 1990\u20132020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. 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