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With improvements in the medical industry and its technology, computer-aided diagnosis (CAD) systems have been essential in detecting early cancer signs in patients that could not be observed physically, exclusive of introducing errors. CAD is a detection system that combines artificially intelligent techniques with image processing applications thru computer vision. Several manual procedures are reported in state of the art for cancer diagnosis. Still, they are costly, time-consuming and diagnose cancer in late stages such as CT scans, radiography, and MRI scan. In this research, numerous state-of-the-art approaches on multi-organs detection using clinical practices are evaluated, such as cancer, neurological, psychiatric, cardiovascular and abdominal imaging. Additionally, numerous sound approaches are clustered together and their results are assessed and compared on benchmark datasets. Standard metrics such as accuracy, sensitivity, specificity and false-positive rate are employed to check the validity of the current models reported in the literature. Finally, existing issues are highlighted and possible directions for future work are also suggested.<\/jats:p>","DOI":"10.1186\/s41824-024-00195-8","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T22:08:41Z","timestamp":1711922921000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Computer-aided analysis of radiological images for cancer diagnosis: performance analysis on benchmark datasets, challenges, and directions"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-2641","authenticated-orcid":false,"given":"Jaber","family":"Alyami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"195_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11571-020-09587-5","volume":"14","author":"AA Abbasi","year":"2020","unstructured":"Abbasi AA, Hussain L, Awan IA, Abbasi I, Majid A, Nadeem MSA, Chaudhary QA (2020) Detecting prostate cancer using deep learning convolution neural network with transfer learning approach. 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