{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:37:33Z","timestamp":1782247053588,"version":"3.54.5"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Rep."],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The value of somatostatin-analogon PET tracers in theranostics in cranial meningioma has been demonstrated in several studies however, the value of semi-quantitative parameters for therapy and patient outcome is still unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective study was performed comparing measured semi-quantitative <jats:sup>68<\/jats:sup>Ga-DOTANOC PET\/CT parameters (maximum standardized uptake value\u2009=\u2009SUVmax, mean standardized uptake value\u2009=\u2009SUVmean, and metabolic tumor volume\u2009=\u2009MTV) and calculated ratios (SUVmax tumor\/to pituitary gland, SUVmax tumor to superior sinus sagittalis), versus WHO grades and overall outcome. Patients with histological confirmed meningioma or high probability for meningioma in previous cranial MRI were eligible.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-two patients from January 2018 to February 2023 were retrospectively included. WHO grade I meningioma was confirmed in 17 patients, WHO grade II in five patients, WHO grade III in two patients, while in eight patients diagnosis was solely based on MRI and <jats:sup>68<\/jats:sup>Ga-DOTANOC PET\/CT findings. In 12 cases stable disease was present, in 15 cases radiation therapy was chosen, in three cases neurosurgery was preferred while in two cases palliative care was chosen. Median SUVmax values increased with WHO grade (15.84, 17.22, and 28.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.134, Kruskal\u2013Wallis-test) and no statistically significant difference was present for MTV, SUVmax, and calculated ratios, although the ratio for SUVmax tumor to superior sinus sagittalis had the lowest value of <jats:italic>p<\/jats:italic>\u2009=\u20090.067.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Increased SUVmax values in the tumor in <jats:sup>68<\/jats:sup>Ga-DOTANOC PET\/CT are associated with higher WHO grade, although further studies including larger patient collectives are needed to solidify this hypothesis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41824-024-00204-w","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T23:02:12Z","timestamp":1715727732000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical value of semi-quantitative parameters in 68Ga-DOTANOC PET\/CT in treatment and diagnostics of cranial meningioma in a single-center retrospective analysis"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-8184","authenticated-orcid":false,"given":"Friedrich","family":"Weitzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Stanzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Plhak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reingard Maria","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"204_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/jlcr.3227","volume":"57","author":"J Aerts","year":"2014","unstructured":"Aerts J, Ballinger JR, Behe M et al (2014) Guidance on current good radiopharmacy practice for the small-scale preparation of radiopharmaceuticals using automated modules: a European perspective. 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Being a retrospective study the need for written informed consent was waived by the Ethics Committee at Medical University of Graz.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All contributing authors have contributed equivocally to the paper, read the paper, approved the contents and meet the criteria for authorship as established.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors confirm that there is no conflict of interest\u2014financial or otherwise\u2014to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13"}}