{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:03:23Z","timestamp":1772323403872,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"G-7 Scholarship Foundation"},{"name":"JSPS Grant-in-Aid for Early-Career Scientists in Japan","award":["22K15801"],"award-info":[{"award-number":["22K15801"]}]},{"name":"JSPS Grant-in-Aid for Scientific Research (C) in Japan","award":["20K07990"],"award-info":[{"award-number":["20K07990"]}]},{"name":"JSPS Grant-in-Aid for Scientific Research (C) in Japan","award":["23K07203"],"award-info":[{"award-number":["23K07203"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Rep."],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and purpose<\/jats:title>\n                <jats:p>The ability of [<jats:sup>123<\/jats:sup>I]metaiodobenzylguanidine (MIBG) sympathetic nerve imaging with three-dimensional (3D) quantitation to clinically diagnose neurological disorders has not been evaluated. This study compared absolute heart counts calculated as mean standardized uptake values (SUV<jats:sub>mean<\/jats:sub>) using conventional planar imaging and assessed the contribution of [<jats:sup>123<\/jats:sup>I]MIBG single-photon emission computed tomography (SPECT)-CT to the diagnosis of neurological diseases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Seventy-two patients with neurological diseases were consecutively assessed using early and delayed [<jats:sup>123<\/jats:sup>I]MIBG SPECT-CT and planar imaging. Left ventricles were manually segmented in early and delayed SPECT-CT images, then the SUV<jats:sub>mean<\/jats:sub> and washout rates (WRs) were calculated. Heart-to-mediastinum ratios (HMRs) and WRs on planar images were conventionally computed. We investigated correlations between planar HMRs and SPECT-CT SUV<jats:sub>means<\/jats:sub> and between WRs obtained from planar and SPECT-CT images. The cutoff for SPECT-CT WRs defined by linear regression and that of normal planar WRs derived from a database were compared with neurological diagnoses of the patients. We assigned the patients to groups according to clinical diagnoses as controls (n\u2009=\u20096), multiple system atrophy (MSA, n\u2009=\u20097), progressive supranuclear palsy (PSP, n\u2009=\u200917), and Parkinson\u2019s disease or dementia with Lewy bodies (PD\/DLB, n\u2009=\u200919), then compared SPECT-CT and planar image parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found significant correlations between SPECT-CT SUV<jats:sub>mean<\/jats:sub> and planar HMR on early and delayed images (R<jats:sup>2<\/jats:sup>\u2009=\u20090.69 and 0.82, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and between SPECT-CT and planar WRs (R<jats:sup>2<\/jats:sup>\u2009=\u20090.79, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). A threshold of 31% for SPECT-CT WR based on linear regression resulted in agreement between planar and SPECT-CT WR in 67 (93.1%) of 72 patients. Compared with controls, early and delayed SUV<jats:sub>mean<\/jats:sub> in patients with PSP and MSA tended more towards significance than planar HMR. This trend was similar for SPECT-CT WRs in patients with PSP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Absolute heart counts and SUV<jats:sub>mean<\/jats:sub> determined using [<jats:sup>123<\/jats:sup>I]MIBG SPECT-CT correlated with findings of conventional planar images in patients with neurological diseases. Three-dimensional quantitation with [<jats:sup>123<\/jats:sup>I]MIBG SPECT-CT imaging might differentiate patients with PSP and MSA from controls.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s41824-024-00205-9","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T01:04:14Z","timestamp":1717203854000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Absolute quantitation of sympathetic nerve activity using [123I] metaiodobenzylguanidine SPECT-CT in neurology"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-1715","authenticated-orcid":false,"given":"Shintaro","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-8746","authenticated-orcid":false,"given":"Kenichi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Shibutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Kinuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"issue":"5","key":"205_CR1","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s12350-017-1183-6","volume":"26","author":"TM Bateman","year":"2019","unstructured":"Bateman TM, Ananthasubramaniam K, Berman DS, Gerson M, Gropler R, Henzlova M et al (2019) Reliability of the [123I]mIBG heart\/mediastinum ratio: results of a multicenter test-retest reproducibility study. 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Tokyo, Japan, which supplied the [<sup>123<\/sup>I]MIBG. All other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}