{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:08:39Z","timestamp":1759529319475,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Rheumatol"],"DOI":"10.1186\/s41927-024-00408-4","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:01:47Z","timestamp":1726732907000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A higher body mass index and increased syndesmophytes volume are associated with facet joints ankylosis on thoracic spine in patients with ankylosing spondylitis: a retrospective cohort study"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-5009","authenticated-orcid":false,"given":"Simin","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuquan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-9917","authenticated-orcid":false,"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-873X","authenticated-orcid":false,"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"408_CR1","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1136\/annrheumdis-2021-221035","volume":"80","author":"V Navarro-Comp\u00e1n","year":"2021","unstructured":"Navarro-Comp\u00e1n V, Sepriano A, El-Zorkany B, Van der Heijde D. Axial spondyloarthritis. Ann Rheum Dis. 2021;80:1511\u201321.","journal-title":"Ann Rheum Dis"},{"key":"408_CR2","doi-asserted-by":"publisher","first-page":"151991","DOI":"10.1016\/j.semarthrit.2022.151991","volume":"55","author":"G Slobodin","year":"2022","unstructured":"Slobodin G, Sagiv M, Khreish T, et al. Facet joint disease in patients with axial spondyloarthritis: a retrospective computed tomography study. Semin Arthritis Rheum. 2022;55:151991.","journal-title":"Semin Arthritis Rheum"},{"key":"408_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11926-018-0759-8","volume":"20","author":"MM Ward","year":"2018","unstructured":"Ward MM, Tan S. Better quantification of Syndesmophyte growth in axial Spondyloarthritis. Curr Rheumatol Rep. 2018;20:46.","journal-title":"Curr Rheumatol Rep"},{"key":"408_CR4","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1093\/rheumatology\/keaa155","volume":"59","author":"R Stal","year":"2020","unstructured":"Stal R, Gaalen FV, Sepriano A, et al. Facet joint ankylosis in r-axSpA: detection and 2-year progression on whole spine low-dose CT and comparison with syndesmophyte progression. Rheumatology (Oxford). 2020;59:3776\u201383.","journal-title":"Rheumatology (Oxford)"},{"key":"408_CR5","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.semarthrit.2021.07.015","volume":"51","author":"JY Jung","year":"2021","unstructured":"Jung JY, Kim MY, Hong YS, et al. Association between facet joint ankylosis and functional impairment in patients with radiographic axial spondyloarthritis. Semin Arthritis Rheum. 2021;51:1005\u201310.","journal-title":"Semin Arthritis Rheum"},{"key":"408_CR6","first-page":"1738","volume":"26","author":"K de Vlam","year":"1999","unstructured":"de Vlam K, Mielants H, Veys EM. Involvement of the zygapophyseal joint in ankylosing spondylitis: relation to the bridging syndesmophyte. J Rheumatol. 1999;26:1738\u201345.","journal-title":"J Rheumatol"},{"key":"408_CR7","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3899\/jrheum.161462","volume":"44","author":"S Tan","year":"2017","unstructured":"Tan S, Yao J, Flynn JA, et al. Zygapophyseal joint fusion in ankylosing spondylitis assessed by computed tomography: associations with syndesmophytes and spinal motion. J Rheumatol. 2017;44:1004\u201310.","journal-title":"J Rheumatol"},{"key":"408_CR8","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1093\/rheumatology\/keac176","volume":"61","author":"S Rosalinde","year":"2022","unstructured":"Rosalinde S, Alexandre S, Alexander V, et al. Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years. Rheumatology (Oxford). 2022;61:4722\u201330.","journal-title":"Rheumatology (Oxford)"},{"key":"408_CR9","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1007\/s00330-019-06047-5","volume":"29","author":"L Berg","year":"2019","unstructured":"Berg L, Thoresen H, Neckelmann G, et al. Facet arthropathy evaluation: CT or MRI? Eur Radiol. 2019;29:4990\u20138.","journal-title":"Eur Radiol"},{"key":"408_CR10","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1001\/archpsyc.61.3.310","volume":"61","author":"R Gueorguieva","year":"2004","unstructured":"Gueorguieva R, Krystal JH. Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. Arch Gen Psychiatry. 2004;61:310\u20137.","journal-title":"Arch Gen Psychiatry"},{"key":"408_CR11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/BOR.0000000000000507","volume":"30","author":"S Tan","year":"2018","unstructured":"Tan S, Ward MM. Computed tomography in axial spondyloarthritis. Curr Opin Rheumatol. 2018;30:334\u20139.","journal-title":"Curr Opin Rheumatol"},{"key":"408_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1136\/annrheumdis-2017-212553","volume":"77","author":"F de Bruin","year":"2018","unstructured":"de Bruin F, de Koning A, van den Berg R, et al. Development of the CT Syndesmophyte Score (CTSS) in patients with ankylosing spondylitis: data from the SIAS cohort. Ann Rheum Dis. 2018;77:371\u20137.","journal-title":"Ann Rheum Dis"},{"key":"408_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.clinimag.2021.07.005","volume":"80","author":"RM Kwee","year":"2021","unstructured":"Kwee RM, Kwee TC. Imaging of facet joint diseases. Clin Imaging. 2021;80:167\u201379.","journal-title":"Clin Imaging"},{"key":"408_CR14","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/annrheumdis-2013-203643","volume":"73","author":"P Jacques","year":"2014","unstructured":"Jacques P, Lambrecht S, Verheugen E, et al. Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann Rheum Dis. 2014;73:437\u201345.","journal-title":"Ann Rheum Dis"},{"key":"408_CR15","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1136\/annrheumdis-2018-214675","volume":"78","author":"S Tan","year":"2019","unstructured":"Tan S, Dasgupta A, Flynn JA, et al. Aortic-vertebral interaction in ankylosing spondylitis: syndesmophyte development at the juxta-aortic vertebral rim. Ann Rheum Dis. 2019;78:922\u20138.","journal-title":"Ann Rheum Dis"},{"key":"408_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/RHU.0000000000000698","volume":"24","author":"R Sebro","year":"2018","unstructured":"Sebro R. Confirmation of the influence of descending aorta on osteophyte formation in dish. J Clin Rheumatol. 2018;24:351\u20133.","journal-title":"J Clin Rheumatol"},{"key":"408_CR17","doi-asserted-by":"publisher","first-page":"4910","DOI":"10.1093\/rheumatology\/keac183","volume":"61","author":"M Gliner-Ron","year":"2022","unstructured":"Gliner-Ron M, Bercovich E, Herman A, et al. Osteophytes\u2019 position in subjects with DISH and right-sided aorta: verification of the \u2018aortic pulsation protective effect\u2019 theory. Rheumatology (Oxford). 2022;61:4910\u20134.","journal-title":"Rheumatology (Oxford)"},{"key":"408_CR18","doi-asserted-by":"publisher","first-page":"e002250","DOI":"10.1136\/rmdopen-2022-002250","volume":"8","author":"S Rosalinde","year":"2022","unstructured":"Rosalinde S, Xenofon B, Van der Heijde D, et al. Role of vertebral corner inflammation and fat deposition on MRI on syndesmophyte development detected on whole spine low-dose CT scan in radiographic axial spondyloarthritis. RMD Open. 2022;8:e002250.","journal-title":"RMD Open"},{"key":"408_CR19","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1097\/BOR.0000000000000179","volume":"27","author":"S Tan","year":"2015","unstructured":"Tan S, Wang RS, Ward MM. Syndesmophyte growth in ankylosing spondylitis. Curr Opin Rheumatol. 2015;27:326\u201332.","journal-title":"Curr Opin Rheumatol"},{"key":"408_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00296-015-3360-8","volume":"36","author":"SZ Aydin","year":"2016","unstructured":"Aydin SZ, Can M, Alibaz-Oner F, et al. A relationship between spinal new bone formation in ankylosing spondylitis and the sonographically determined Achilles tendon enthesophytes. Rheumatol Int. 2016;36:397\u2013404.","journal-title":"Rheumatol Int"},{"key":"408_CR21","first-page":"144","volume":"38","author":"S Bakirci","year":"2020","unstructured":"Bakirci S, Dabague J, Eder L, et al. The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging. Clin Exp Rheumatol. 2020;38:144\u20138.","journal-title":"Clin Exp Rheumatol"},{"key":"408_CR22","doi-asserted-by":"publisher","unstructured":"Lee BW, Jung JY, Kim MY, et al. Prevalence and associated factors of facet joint ankylosis in patients with axial spondyloarthritis. J Rheumatol.\u00a02023;50(6):763\u20138. https:\/\/doi.org\/10.3899\/jrheum.220749. Epub 2023 Jan 15.","DOI":"10.3899\/jrheum.220749"},{"key":"408_CR23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11926-020-00972-x","volume":"23","author":"R Mader","year":"2021","unstructured":"Mader R, Pappone N, Xenofon B, et al. Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component. Curr Rheumatol Rep. 2021;23:6.","journal-title":"Curr Rheumatol Rep"},{"key":"408_CR24","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.2174\/092986707780362826","volume":"14","author":"E Toussirot","year":"2007","unstructured":"Toussirot E, Streit G, Wendling D. The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem. 2007;14:1095\u2013100.","journal-title":"Curr Med Chem"},{"key":"408_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00394-012-0370-0","volume":"51","author":"R Krysiak","year":"2012","unstructured":"Krysiak R, Handzlik-Orlik G, Okopien B. The role of adipokines in connective tissue diseases. Eur J Nutr. 2012;51:513\u201328.","journal-title":"Eur J Nutr"},{"key":"408_CR26","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1359\/jbmr.060707","volume":"21","author":"XH Luo","year":"2006","unstructured":"Luo XH, Guo LJ, Xie H, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res. 2006;21:1648\u201356.","journal-title":"J Bone Miner Res"},{"key":"408_CR27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/jcb.20890","volume":"99","author":"Y Shinoda","year":"2006","unstructured":"Shinoda Y, YamaguchiM ON, Akune T, et al. Regulation of bone formation by adiponectin through autocrine\/paracrine and endocrine pathways. J Cell Biochem. 2006;99:196\u2013208.","journal-title":"J Cell Biochem"},{"key":"408_CR28","volume-title":"Linear mixed models for longitudinal data","author":"GM Geert Verbeke","year":"2000","unstructured":"Geert Verbeke GM. Linear mixed models for longitudinal data. New York: Springer; 2000."}],"container-title":["BMC Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-024-00408-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41927-024-00408-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-024-00408-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:01:55Z","timestamp":1726732915000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcrheumatol.biomedcentral.com\/articles\/10.1186\/s41927-024-00408-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["408"],"URL":"https:\/\/doi.org\/10.1186\/s41927-024-00408-4","relation":{},"ISSN":["2520-1026"],"issn-type":[{"type":"electronic","value":"2520-1026"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"24 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by \u2018Ethics Committee of Chinese PLA General Hospital\u2019 (S2023-168\u201301). Informed consent was waived by \u2018Ethics Committee of Chinese PLA General Hospital\u2019 because this study retrospectively reviewed the electronic medical records and imaging data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}