{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:17:16Z","timestamp":1777414636790,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Rheumatol"],"DOI":"10.1186\/s41927-025-00508-9","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:52:15Z","timestamp":1747972335000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rheumatologic manifestations in children with underlying inborn errors of immunity"],"prefix":"10.1186","volume":"9","author":[{"given":"Zohreh","family":"Saeidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Fadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnaz","family":"Mesdaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh Zeinab","family":"Mirzaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samin","family":"Sharafian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khosro","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadood Javadi","family":"Parvaneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Talebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Chavoshzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Shiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"issue":"9","key":"508_CR1","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.cgh.2013.02.024","volume":"11","author":"S Agarwal","year":"2013","unstructured":"Agarwal S, Mayer L. Diagnosis and treatment of Gastrointestinal disorders in patients with primary immunodeficiency. Clin Gastroenterol Hepatol. 2013;11(9):1050\u201363.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"508_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/BOR.0b013e32831cb939","volume":"21","author":"R Goyal","year":"2009","unstructured":"Goyal R, et al. Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol. 2009;21(1):78.","journal-title":"Curr Opin Rheumatol"},{"key":"508_CR3","first-page":"77","volume":"2","author":"M Jesenak","year":"2014","unstructured":"Jesenak M, et al. Pulmonary manifestations of primary immunodeficiency disorders in children. Front Pead. 2014;2:77.","journal-title":"Front Pead"},{"issue":"2","key":"508_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12016-013-8377-8","volume":"46","author":"H Lehman","year":"2014","unstructured":"Lehman H. Skin manifestations of primary immune deficiency. Clin Rev Allergy Immunol. 2014;46(2):112\u20139.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"15","key":"508_CR5","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1182\/blood-2014-06-583260","volume":"124","author":"MG Seidel","year":"2014","unstructured":"Seidel MG. Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatment. Blood. 2014;124(15):2337\u201344.","journal-title":"Blood"},{"issue":"7","key":"508_CR6","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","volume":"42","author":"SG Tangye","year":"2022","unstructured":"Tangye SG, et al. Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee. J Clin Immunol. 2022;42(7):1473\u2013507.","journal-title":"J Clin Immunol"},{"key":"508_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/5584_2020_556","volume":"1289","author":"A Lewandowicz-Uszy\u0144ska","year":"2021","unstructured":"Lewandowicz-Uszy\u0144ska A, et al. Primary immunodeficiencies: diseases of children and Adults - A review. Adv Exp Med Biol. 2021;1289:37\u201354.","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"508_CR8","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1007\/s10875-022-01352-z","volume":"42","author":"A Bousfiha","year":"2022","unstructured":"Bousfiha A, et al. The 2022 update of IUIS phenotypical classification for human inborn errors of immunity. J Clin Immunol. 2022;42(7):1508\u201320.","journal-title":"J Clin Immunol"},{"key":"508_CR9","doi-asserted-by":"crossref","unstructured":"The French National registry of primary immunodeficiency diseases. Clin Immunol. 2010;135(2):264\u201372.","DOI":"10.1016\/j.clim.2010.02.021"},{"issue":"5","key":"508_CR10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10875-007-9105-z","volume":"27","author":"P Kirkpatrick","year":"2007","unstructured":"Kirkpatrick P, Riminton S. Primary immunodeficiency diseases in Australia and new Zealand. J Clin Immunol. 2007;27(5):517\u201324.","journal-title":"J Clin Immunol"},{"issue":"3","key":"508_CR11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/cei.13125","volume":"192","author":"B Shillitoe","year":"2018","unstructured":"Shillitoe B, et al. The united Kingdom primary immune deficiency (UKPID) registry 2012 to 2017. Clin Exp Immunol. 2018;192(3):284\u201391.","journal-title":"Clin Exp Immunol"},{"issue":"8","key":"508_CR12","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s10875-014-0102-8","volume":"34","author":"L Kobrynski","year":"2014","unstructured":"Kobrynski L, Powell RW, Bowen S. Prevalence and morbidity of primary immunodeficiency diseases, united States 2001\u20132007. J Clin Immunol. 2014;34(8):954\u201361.","journal-title":"J Clin Immunol"},{"issue":"1","key":"508_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10875-009-9357-x","volume":"30","author":"L Yel","year":"2010","unstructured":"Yel L. Selective IgA deficiency. J Clin Immunol. 2010;30(1):10\u20136.","journal-title":"J Clin Immunol"},{"issue":"1","key":"508_CR14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000236330","volume":"99","author":"RS Liblau","year":"1992","unstructured":"Liblau RS, Bach J-F. Selective IgA deficiency and autoimmunity. Int Arch Allergy Immunol. 1992;99(1):16\u201327.","journal-title":"Int Arch Allergy Immunol"},{"issue":"8","key":"508_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1177\/0961203307077543","volume":"16","author":"JT Cassidy","year":"2007","unstructured":"Cassidy JT, Kitson RK, Selby CL. Selective IgA deficiency in children and adults with systemic lupus erythematosus. Lupus. 2007;16(8):647\u201350.","journal-title":"Lupus"},{"issue":"4","key":"508_CR16","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.autrev.2008.11.004","volume":"8","author":"G Bussone","year":"2009","unstructured":"Bussone G, Mouthon L. Autoimmune manifestations in primary immune deficiencies. Autoimmun Rev. 2009;8(4):332\u20136.","journal-title":"Autoimmun Rev"},{"issue":"5","key":"508_CR17","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1002\/art.33472","volume":"64","author":"WFC Rigby","year":"2012","unstructured":"Rigby WFC, et al. Increased frequency of complement C4B deficiency in rheumatoid arthritis. Arthr Rhuem. 2012;64(5):1338\u201344.","journal-title":"Arthr Rhuem"},{"issue":"6","key":"508_CR18","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/00008480-199810060-00011","volume":"10","author":"KE Sullivan","year":"1998","unstructured":"Sullivan KE. Complement deficiency and autoimmunity. Curr Opin Pediatr. 1998;10(6):600\u20136.","journal-title":"Curr Opin Pediatr"},{"issue":"1","key":"508_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12969-015-0050-8","volume":"13","author":"M Sp\u00e2rchez","year":"2015","unstructured":"Sp\u00e2rchez M, et al. Primary complement and antibody deficiencies in autoimmune rheumatologic diseases with juvenile onset: a prospective study at two centers. Pediatr Rheumatol. 2015;13(1):51.","journal-title":"Pediatr Rheumatol"},{"issue":"4","key":"508_CR20","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s10067-016-3229-6","volume":"35","author":"VR Dimitriades","year":"2016","unstructured":"Dimitriades VR, Sorensen R. Rheumatologic manifestations of primary immunodeficiency diseases. Clin Rheumatol. 2016;35(4):843\u201350.","journal-title":"Clin Rheumatol"},{"key":"508_CR21","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3389\/fimmu.2014.00627","volume":"5","author":"H Chapel","year":"2014","unstructured":"Chapel H, et al. Primary immune deficiencies\u2013principles of care. Front Immunol. 2014;5:627.","journal-title":"Front Immunol"},{"issue":"6","key":"508_CR22","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","volume":"7","author":"MG Seidel","year":"2019","unstructured":"Seidel MG, et al. The European society for immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7(6):1763\u201370.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"Suppl 1","key":"508_CR23","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1016\/j.jped.2020.10.004","volume":"97","author":"ES Goudouris","year":"2021","unstructured":"Goudouris ES. Immunodeficiencies: non-infectious manifestations. J Pediatr (Rio J). 2021;97(Suppl 1):S24\u201333.","journal-title":"J Pediatr (Rio J)"},{"issue":"11","key":"508_CR24","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1080\/1744666X.2017.1384312","volume":"13","author":"G Azizi","year":"2017","unstructured":"Azizi G, et al. Autoimmunity in a cohort of 471 patients with primary antibody deficiencies. Expert Rev Clin Immunol. 2017;13(11):1099\u2013106.","journal-title":"Expert Rev Clin Immunol"},{"issue":"6","key":"508_CR25","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/ACI.0000000000000583","volume":"19","author":"M Kitcharoensakkul","year":"2019","unstructured":"Kitcharoensakkul M, Cooper MA. Rheumatologic and autoimmune manifestations in primary immune deficiency. Curr Opin Allergy Clin Immunol. 2019;19(6):545\u201352.","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"13","key":"508_CR26","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1177\/0961203313507990","volume":"22","author":"E Lim","year":"2013","unstructured":"Lim E, et al. Hypogammaglobulinemia in pediatric systemic lupus erythematosus. Lupus. 2013;22(13):1382\u20137.","journal-title":"Lupus"},{"key":"508_CR27","doi-asserted-by":"crossref","unstructured":"Padem N et al. Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry. Clin Rheumatol. 2022:41.","DOI":"10.1007\/s10067-021-06044-4"},{"issue":"5","key":"508_CR28","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.jaci.2016.12.978","volume":"140","author":"A Fischer","year":"2017","unstructured":"Fischer A, et al. Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2017;140(5):1388\u201393.","journal-title":"J Allergy Clin Immunol"}],"container-title":["BMC Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-025-00508-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41927-025-00508-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-025-00508-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T16:04:14Z","timestamp":1748016254000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcrheumatol.biomedcentral.com\/articles\/10.1186\/s41927-025-00508-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["508"],"URL":"https:\/\/doi.org\/10.1186\/s41927-025-00508-9","relation":{},"ISSN":["2520-1026"],"issn-type":[{"value":"2520-1026","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]},"assertion":[{"value":"26 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In our retrospective study, in line with the Declaration of Helsinki, the need for obtaining informed consent on a case-by-case basis was waivered by the Research Ethics Committee of the School of Medicine - Shahid Beheshti University of Medical Sciences and the study design and methods were approved under the approval ID IR.SBMU.MSP.REC.1398.434.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}