{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:49:05Z","timestamp":1780480145848,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1051777"],"award-info":[{"award-number":["23CDA1051777"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute on Aging of the NIH","award":["R03\u2010AG067949"],"award-info":[{"award-number":["R03\u2010AG067949"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Rheumatol"],"DOI":"10.1186\/s41927-025-00525-8","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:31:29Z","timestamp":1749457889000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of lifestyle modification on metabolic pathways in older adults with overweight\/obesity and rheumatoid arthritis: a secondary exploratory analysis of the SWET-RA study"],"prefix":"10.1186","volume":"9","author":[{"given":"Grace","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna M.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa M.","family":"Sudnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl F.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery A.","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ilkayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Muehlbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie W.","family":"Bales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn N.","family":"Porter Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Andonian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"525_CR1","unstructured":"Chauhan K, Jandu JS, Brent LH, Al-Dhahir MA. Rheumatoid arthritis. StatPearls. Treasure Island (FL): StatPearls publishing copyright \u00a9 2025. StatPearls Publishing LLC.; 2025."},{"issue":"3","key":"525_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/BOR.0000000000000697","volume":"32","author":"BJ Andonian","year":"2020","unstructured":"Andonian BJ, Huffman KM. Skeletal muscle disease in rheumatoid arthritis: the center of cardiometabolic comorbidities? Curr Opin Rheumatol. 2020;32(3):297\u2013306.","journal-title":"Curr Opin Rheumatol"},{"issue":"11","key":"525_CR3","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrrheum.2014.121","volume":"10","author":"G Kerekes","year":"2014","unstructured":"Kerekes G, Nurmohamed MT, Gonz\u00e1lez-Gay MA, Seres I, Paragh G, Kardos Z, et al. Rheumatoid arthritis and metabolic syndrome. Nat Rev Rheumatol. 2014;10(11):691\u20136.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"525_CR4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13075-021-02570-3","volume":"23","author":"BJ Andonian","year":"2021","unstructured":"Andonian BJ, Johannemann A, Hubal MJ, Pober DM, Koss A, Kraus WE, et al. Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis. Arthritis Res Ther. 2021;23(1):187.","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"525_CR5","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1093\/rheumatology\/keu224","volume":"53","author":"E Choy","year":"2014","unstructured":"Choy E, Ganeshalingam K, Semb AG, Szekanecz Z, Nurmohamed M. Cardiovascular risk in rheumatoid arthritis: recent advances in the Understanding of the pivotal role of inflammation, risk predictors and the impact of treatment. Rheumatology (Oxford). 2014;53(12):2143\u201354.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"525_CR6","first-page":"115","volume":"33","author":"P Jiang","year":"2015","unstructured":"Jiang P, Li H, Li X. Diabetes mellitus risk factors in rheumatoid arthritis: a systematic review and meta-analysis. Clin Exp Rheumatol. 2015;33(1):115\u201321.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"525_CR7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jbspin.2016.09.001","volume":"84","author":"J Nicolau","year":"2017","unstructured":"Nicolau J, Lequerr\u00e9 T, Bacquet H, Vittecoq O. Rheumatoid arthritis, insulin resistance, and diabetes. Joint Bone Spine. 2017;84(4):411\u20136.","journal-title":"Joint Bone Spine"},{"issue":"1","key":"525_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12944-017-0427-4","volume":"16","author":"H AbouAssi","year":"2017","unstructured":"AbouAssi H, Connelly MA, Bateman LA, Tune KN, Huebner JL, Kraus VB, et al. Does a lack of physical activity explain the rheumatoid arthritis lipid profile? Lipids Health Dis. 2017;16(1):39.","journal-title":"Lipids Health Dis"},{"issue":"1","key":"525_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13075-016-1215-7","volume":"19","author":"KM Huffman","year":"2017","unstructured":"Huffman KM, Jessee R, Andonian B, Davis BN, Narowski R, Huebner JL, et al. Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability. Arthritis Res Ther. 2017;19(1):12.","journal-title":"Arthritis Res Ther"},{"issue":"7S Suppl 2","key":"525_CR10","doi-asserted-by":"publisher","first-page":"S116","DOI":"10.1097\/RHU.0000000000001064","volume":"26","author":"JM Garc\u00eda-Morales","year":"2020","unstructured":"Garc\u00eda-Morales JM, Lozada-Mellado M, Hinojosa-Azaola A, Llorente L, Ogata-Medel M, Pineda-Ju\u00e1rez JA, et al. Effect of a dynamic exercise program in combination with mediterranean diet on quality of life in women with rheumatoid arthritis. J Clin Rheumatol. 2020;26(7S Suppl 2):S116\u201322.","journal-title":"J Clin Rheumatol"},{"issue":"4","key":"525_CR11","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1080\/09593985.2020.1777605","volume":"38","author":"JA Pineda-Ju\u00e1rez","year":"2022","unstructured":"Pineda-Ju\u00e1rez JA, Lozada-Mellado M, Hinojosa-Azaola A, Garc\u00eda-Morales JM, Ogata-Medel M, Llorente L, et al. Changes in hand grip strength and body weight after a dynamic exercise program and mediterranean diet in women with rheumatoid arthritis: a randomized clinical trial. Physiother Theory Pract. 2022;38(4):504\u201312.","journal-title":"Physiother Theory Pract"},{"key":"525_CR12","doi-asserted-by":"crossref","unstructured":"Andonian BJ, Ross LM, Sudnick AM, Johnson JL, Pieper CF, Belski KB, et al. Effect of remotely supervised weight loss and exercise training versus lifestyle counseling on cardiovascular risk and clinical outcomes in older adults with rheumatoid arthritis: A randomized controlled trial. ACR Open Rheumatology. 2024;6(3):124\u201336.","DOI":"10.1002\/acr2.11639"},{"key":"525_CR13","doi-asserted-by":"publisher","first-page":"101261","DOI":"10.1016\/j.eclinm.2021.101261","volume":"43","author":"KM Huffman","year":"2022","unstructured":"Huffman KM, Parker DC, Bhapkar M, Racette SB, Martin CK, Redman LM, et al. Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: distinct influences of BMI and sex from CALERIE\u2122 a multicentre, phase 2, randomised controlled trial. EClinicalMedicine. 2022;43:101261.","journal-title":"EClinicalMedicine"},{"issue":"7","key":"525_CR14","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrm.2016.25","volume":"17","author":"CH Johnson","year":"2016","unstructured":"Johnson CH, Ivanisevic J, Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol. 2016;17(7):451\u20139.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"18","key":"525_CR15","doi-asserted-by":"publisher","first-page":"e2100388","DOI":"10.1002\/pmic.202100388","volume":"22","author":"MS Kaspy","year":"2022","unstructured":"Kaspy MS, Semnani-Azad Z, Malik VS, Jenkins DJA, Hanley AJ. Metabolomic profile of combined healthy lifestyle behaviours in humans: A systematic review. Proteomics. 2022;22(18):e2100388.","journal-title":"Proteomics"},{"key":"525_CR16","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/geroni\/igab046.3249","volume":"5","author":"B Andonian","year":"2021","unstructured":"Andonian B, Bartlett D, MacIver N, Kraus W, Huffman K. Effect of High-Intensity interval training on rheumatoid arthritis CD4\u2009+\u2009T cell oxidative metabolism. Innov Aging. 2021;5:901.","journal-title":"Innov Aging"},{"key":"525_CR17","doi-asserted-by":"publisher","first-page":"7450","DOI":"10.1038\/s41598-022-11458-4","volume":"12","author":"B Andonian","year":"2022","unstructured":"Andonian B, Koss A, Koves T, Hauser E, Hubal M, Pober D, et al. Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness. Sci Rep. 2022;12:7450.","journal-title":"Sci Rep"},{"issue":"6","key":"525_CR18","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.cell.2014.11.034","volume":"159","author":"DM Muoio","year":"2014","unstructured":"Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 2014;159(6):1253\u201362.","journal-title":"Cell"},{"issue":"5","key":"525_CR19","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cmet.2012.04.005","volume":"15","author":"DM Muoio","year":"2012","unstructured":"Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, DeBalsi KL, et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab. 2012;15(5):764\u201377.","journal-title":"Cell Metab"},{"issue":"5","key":"525_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/acr2.11536","volume":"5","author":"B Andonian","year":"2023","unstructured":"Andonian B, Ross LM, Zidek AM, Fos LB, Piner LW, Johnson JL, et al. Remotely supervised weight loss and exercise training to improve rheumatoid arthritis cardiovascular risk: rationale and design of the supervised weight loss plus exercise training-Rheumatoid arthritis trial. ACR Open Rheumatol. 2023;5(5):252\u201363.","journal-title":"ACR Open Rheumatol"},{"issue":"Suppl 6","key":"525_CR21","doi-asserted-by":"publisher","first-page":"vi5","DOI":"10.1093\/rheumatology\/kes279","volume":"51","author":"J Kay","year":"2012","unstructured":"Kay J, Upchurch KS. ACR\/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford). 2012;51(Suppl 6):vi5\u20139.","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"525_CR22","doi-asserted-by":"publisher","first-page":"e005263","DOI":"10.1161\/CIRCOUTCOMES.118.005263","volume":"11","author":"KL Piercy","year":"2018","unstructured":"Piercy KL, Troiano RP. Physical activity guidelines for Americans from the US department of health and human services. Circ Cardiovasc Qual Outcomes. 2018;11(11):e005263.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"1","key":"525_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1089\/omi.2008.0035","volume":"13","author":"LF Lien","year":"2009","unstructured":"Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, et al. The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. Omics. 2009;13(1):21\u201335.","journal-title":"Omics"},{"issue":"3","key":"525_CR24","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3233\/JAD-220906","volume":"91","author":"DC Parker","year":"2023","unstructured":"Parker DC, Kraus WE, Whitson HE, Kraus VB, Smith PJ, Cohen HJ, et al. Tryptophan metabolism and neurodegeneration: longitudinal associations of kynurenine pathway metabolites with cognitive performance and plasma alzheimer\u2019s disease and related dementias biomarkers in the Duke physical performance across the lifespan study. J Alzheimers Dis. 2023;91(3):1141\u201350.","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"525_CR25","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.3390\/jcm9092915","volume":"9","author":"S Bedi","year":"2020","unstructured":"Bedi S, Garcia E, Jeyarajah EJ, Shalaurova I, Perez-Matos MC, Jiang ZG, et al. Characterization of LP-Z lipoprotein particles and quantification in subjects with liver disease using a newly developed NMR-Based assay. J Clin Med. 2020;9(9):2915.","journal-title":"J Clin Med"},{"issue":"16\u201317","key":"525_CR26","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.clinbiochem.2017.06.003","volume":"50","author":"E Garcia","year":"2017","unstructured":"Garcia E, Wolak-Dinsmore J, Wang Z, Li XS, Bennett DW, Connelly MA, et al. NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting. Clin Biochem. 2017;50(16\u201317):947\u201355.","journal-title":"Clin Biochem"},{"issue":"19","key":"525_CR27","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP)","year":"2001","unstructured":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA. 2001;285(19):2486\u201397.","journal-title":"JAMA"},{"issue":"16\u201317","key":"525_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.clinbiochem.2014.07.015","volume":"47","author":"SP Matyus","year":"2014","unstructured":"Matyus SP, Braun PJ, Wolak-Dinsmore J, Jeyarajah EJ, Shalaurova I, Xu Y, et al. NMR measurement of LDL particle number using the Vantera clinical analyzer. Clin Biochem. 2014;47(16\u201317):203\u201310.","journal-title":"Clin Biochem"},{"issue":"1","key":"525_CR29","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van \u2018t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38(1):44\u20138.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"525_CR30","doi-asserted-by":"publisher","first-page":"e0138543","DOI":"10.1371\/journal.pone.0138543","volume":"10","author":"SJ Bartlett","year":"2015","unstructured":"Bartlett SJ, Orbai AM, Duncan T, DeLeon E, Ruffing V, Clegg-Smith K, et al. Reliability and validity of selected PROMIS measures in people with rheumatoid arthritis. PLoS ONE. 2015;10(9):e0138543.","journal-title":"PLoS ONE"},{"issue":"1","key":"525_CR31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2337\/dc10-0709","volume":"34","author":"KM Huffman","year":"2011","unstructured":"Huffman KM, Slentz CA, Bateman LA, Thompson D, Muehlbauer MJ, Bain JR, et al. Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. Diabetes Care. 2011;34(1):174\u20136.","journal-title":"Diabetes Care"},{"issue":"1","key":"525_CR32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2337\/dc10-0709","volume":"34","author":"KM Huffman","year":"2010","unstructured":"Huffman KM, Slentz CA, Bateman LA, Thompson D, Muehlbauer MJ, Bain JR, et al. Exercise-Induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. Diabetes Care. 2010;34(1):174\u20136.","journal-title":"Diabetes Care"},{"key":"525_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","volume":"81","author":"DA Hood","year":"2019","unstructured":"Hood DA, Memme JM, Oliveira AN, Triolo M. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Annu Rev Physiol. 2019;81:19\u201341.","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"525_CR34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s13142-015-0353-9","volume":"6","author":"JD Brown","year":"2016","unstructured":"Brown JD, Buscemi J, Milsom V, Malcolm R, O\u2019Neil PM. Effects on cardiovascular risk factors of weight losses limited to 5\u201310. Transl Behav Med. 2016;6(3):339\u201346.","journal-title":"Transl Behav Med"},{"issue":"2","key":"525_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.tem.2023.10.002","volume":"35","author":"PMM Ruppert","year":"2024","unstructured":"Ruppert PMM, Kersten S. Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting. Trends Endocrinol Metabolism. 2024;35(2):107\u201324.","journal-title":"Trends Endocrinol Metabolism"},{"issue":"6","key":"525_CR36","doi-asserted-by":"crossref","first-page":"E1130","DOI":"10.1152\/ajpcell.1999.277.6.C1130","volume":"277","author":"DE Kelley","year":"1999","unstructured":"Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol. 1999;277(6):E1130\u201341.","journal-title":"Am J Physiol"},{"key":"525_CR37","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3389\/fnmol.2017.00377","volume":"10","author":"M Elamin","year":"2017","unstructured":"Elamin M, Ruskin DN, Masino SA, Sacchetti P. Ketone-Based metabolic therapy: is increased NAD(+) a primary mechanism?? Front Mol Neurosci. 2017;10:377.","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"525_CR38","first-page":"737","volume":"8","author":"PW Wilson","year":"1988","unstructured":"Wilson PW, Abbott RD, Castelli WP. High density lipoprotein cholesterol and mortality. Framingham Heart Study Arterioscler. 1988;8(6):737\u201341.","journal-title":"Framingham Heart Study Arterioscler"},{"issue":"1","key":"525_CR39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12944-023-01993-y","volume":"23","author":"J Chen","year":"2024","unstructured":"Chen J, Fang Z, Luo Q, Wang X, Warda M, Das A, et al. Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets. Lipids Health Dis. 2024;23(1):14.","journal-title":"Lipids Health Dis"},{"issue":"1","key":"525_CR40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12986-016-0119-5","volume":"13","author":"J Cen","year":"2016","unstructured":"Cen J, Sargsyan E, Bergsten P. Fatty acids stimulate insulin secretion from human pancreatic Islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms. Nutr Metab (Lond). 2016;13(1):59.","journal-title":"Nutr Metab (Lond)"},{"key":"525_CR41","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1249\/00003677-199401000-00017","volume":"22","author":"JL Durstine","year":"1994","unstructured":"Durstine JL, Haskell WL. Effects of exercise training on plasma lipids and lipoproteins. Exerc Sport Sci Rev. 1994;22:477\u2013521.","journal-title":"Exerc Sport Sci Rev"},{"issue":"1","key":"525_CR42","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1373\/clinchem.2016.261636","volume":"63","author":"RW McGarrah","year":"2017","unstructured":"McGarrah RW, Kelly JP, Craig DM, Haynes C, Jessee RC, Huffman KM, et al. A novel protein Glycan-Derived inflammation biomarker independently predicts cardiovascular disease and modifies the association of HDL subclasses with mortality. Clin Chem. 2017;63(1):288\u201396.","journal-title":"Clin Chem"},{"issue":"12","key":"525_CR43","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1016\/j.amjcard.2007.07.027","volume":"100","author":"JL Johnson","year":"2007","unstructured":"Johnson JL, Slentz CA, Houmard JA, Samsa GP, Duscha BD, Aiken LB, et al. Exercise training amount and intensity effects on metabolic syndrome (from studies of a targeted risk reduction intervention through defined Exercise). Am J Cardiol. 2007;100(12):1759\u201366.","journal-title":"Am J Cardiol"}],"container-title":["BMC Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-025-00525-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s41927-025-00525-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s41927-025-00525-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T21:02:24Z","timestamp":1749502944000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcrheumatol.biomedcentral.com\/articles\/10.1186\/s41927-025-00525-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["525"],"URL":"https:\/\/doi.org\/10.1186\/s41927-025-00525-8","relation":{},"ISSN":["2520-1026"],"issn-type":[{"value":"2520-1026","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all study participants. The study was approved by the Duke University Health System Institutional Review Board and conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"MAC is an employee of Labcorp. All other authors have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}