{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:03:43Z","timestamp":1780095823094,"version":"3.54.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CVIR Endovasc"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To evaluate outcomes in patients aged\u2009\u2265\u200980 years following large-bore aspiration thrombectomy (LBAT) for the treatment of pulmonary embolism (PE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>All patients\u2009\u2265\u200980 years of age with PE treated via LBAT at a single center were analyzed from September 2019 \u2013 August 2024. This included the octogenarian subgroup from a recently published retrospective analysis assessing all PE patients treated with LBAT at our center between September 2019 and January 2023. The following outcomes were evaluated: technical success, change in several hemodynamic measures including pulmonary artery pressure (PAP) and right ventricle to left ventricle ratio (RV to LV ratio), length of hospital and intensive-care-unit (ICU) stay, procedure-related complications, and 7- and 30-day mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Forty-eight patients aged\u2009\u2265\u200980 years underwent LBAT procedures for PE. Technical success was achieved in 46 cases (95.8%). The mean reduction in mean PAP was 3.6 mmHg. The mean reduction in RV to LV ratio was -0.42. The mean length of postprocedural hospital and ICU stays were 5.7\u2009\u00b1\u20093.6 days and 1.0\u2009\u00b1\u20091.6 days, respectively. There were 2 procedural complications, 1 pulmonary vascular injury involving a pulmonary artery pseudoaneurysm and 1 decompensation involving hypotension requiring vasopressor support. There were no major bleeding complications or cardiac injuries. All-cause mortality was 2.1% (<jats:italic>n<\/jats:italic>\u2009=\u20091) at 7 days and 6.3% (<jats:italic>n<\/jats:italic>\u2009=\u20093) at 30 days post procedure. PE-related mortality was 2.1% (<jats:italic>n<\/jats:italic>\u2009=\u20091) at 30 days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>LBAT is a technically feasible procedure for the treatment of PE in octogenarian patients and has a favorable preliminary safety and mortality profile.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s42155-025-00517-2","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:29:22Z","timestamp":1737520162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians"],"prefix":"10.1186","volume":"8","author":[{"given":"Reid","family":"Masterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-2623","authenticated-orcid":false,"given":"Travis","family":"Pebror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gauger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam William","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah David","family":"Butty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"517_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.amjcard.2023.04.046","volume":"200","author":"I Shatla","year":"2023","unstructured":"Shatla I, Khan MZ, Iskandarani ME, Munir MB, Balla S. In-Hospital outcomes of pulmonary embolism among Nonagenarians (Insights from the National Inpatient Sample). Am J Cardiol. 2023;200:10\u20132. https:\/\/doi.org\/10.1016\/j.amjcard.2023.04.046.","journal-title":"Am J Cardiol"},{"key":"517_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s11739-014-1179-z","volume":"10","author":"H Polo Friz","year":"2015","unstructured":"Polo Friz H, Molteni M, Del Sorbo D, Pasciuti L, Crippa M, Villa G, Meloni DF, Primitz L, Galli A, Rognoni M, Cavalieri d\u2019Oro L, Arpaia G, Cimminiello C. Mortality at 30 and 90 days in elderly patients with pulmonary embolism: a retrospective cohort study. Intern Emerg Med. 2015;10:431\u20136. https:\/\/doi.org\/10.1007\/s11739-014-1179-z.","journal-title":"Intern Emerg Med"},{"key":"517_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","volume":"41","author":"SV Konstantinides","year":"2020","unstructured":"Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jimenez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ni Ainle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL, Group ESCSD. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41:543\u2013603. https:\/\/doi.org\/10.1093\/eurheartj\/ehz405.","journal-title":"Eur Heart J."},{"key":"517_CR4","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1056\/NEJMoa1302097","volume":"370","author":"G Meyer","year":"2014","unstructured":"Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galie N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV, Investigators P. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014;370:1402\u201311. https:\/\/doi.org\/10.1056\/NEJMoa1302097.","journal-title":"N Engl J Med"},{"key":"517_CR5","first-page":"770","volume":"41","author":"C Martin","year":"2016","unstructured":"Martin C, Sobolewski K, Bridgeman P, Boutsikaris D. Systemic thrombolysis for pulmonary embolism: a review. P T. 2016;41:770\u20135.","journal-title":"P T"},{"key":"517_CR6","doi-asserted-by":"publisher","first-page":"e774","DOI":"10.1161\/CIR.0000000000000707","volume":"140","author":"J Giri","year":"2019","unstructured":"Giri J, Sista AK, Weinberg I, Kearon C, Kumbhani DJ, Desai ND, Piazza G, Gladwin MT, Chatterjee S, Kobayashi T, Kabrhel C, Barnes GD. Interventional therapies for acute pulmonary embolism: current status and principles for the development of novel evidence: a scientific statement from the American Heart Association. Circulation. 2019;140:e774\u2013801. https:\/\/doi.org\/10.1161\/CIR.0000000000000707.","journal-title":"Circulation"},{"key":"517_CR7","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4244\/EIJ-D-23-00399","volume":"19","author":"IT Farmakis","year":"2023","unstructured":"Farmakis IT, Barco S, Giannakoulas G, Keller K, Valerio L, Tichelbacker T, Partovi S, Ahrens I, Konstantinides SV, Hobohm L. A nationwide analysis of reperfusion therapies for pulmonary embolism in older patients with frailty. EuroIntervention. 2023;19:772\u201381. https:\/\/doi.org\/10.4244\/EIJ-D-23-00399.","journal-title":"EuroIntervention"},{"key":"517_CR8","doi-asserted-by":"publisher","unstructured":"Al-Terki H, Elhakim A, Mugge A. EKOS(TM) in Octogenarians: The safety and efficacy of ultrasound-accelerated catheter-directed thrombolysis in elderly patients with intermediate-high-risk pulmonary embolism. 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Arq Bras Cardiol. 2022;118:68\u201374. https:\/\/doi.org\/10.36660\/abc.20201060.","journal-title":"Arq Bras Cardiol."}],"container-title":["CVIR Endovascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42155-025-00517-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42155-025-00517-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42155-025-00517-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T16:23:50Z","timestamp":1737563030000},"score":1,"resource":{"primary":{"URL":"https:\/\/CVIRendovasc.springeropen.com\/articles\/10.1186\/s42155-025-00517-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1186\/s42155-025-00517-2","relation":{},"ISSN":["2520-8934"],"issn-type":[{"value":"2520-8934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"8 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This research activity was granted exemption from full Institutional Review Board review and waived informed consent by a qualified staff member of the Human Research Protection Program of Indiana University in accordance with 45 CFR 164.512(i)(2)(ii).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"For this type of study consent for publication is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"R Masterson, T Pebror, A Gauger, and AW Schmitz declare no conflict. SD Butty has received consultant fees from Inari Medical.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}