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While anticoagulation remains the standard treatment, endovascular therapies such as thrombolysis, thrombectomy, and angioplasty are increasingly utilized in selected cases. However, evidence on their outcomes remains limited. This study retrospectively reports the clinical outcomes of ASMVT patients treated with endovascular combination therapies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Between August 2019 and May 2024, 12 patients (males\u2009=\u20099; mean age, 52.33\u2009\u00b1\u200912.51\u00a0years) were diagnosed with ASMVT. The study collected comprehensive data on demographic details, presenting symptoms, etiology, treatment modalities, response to treatment, and follow-up outcomes. Computed Tomography (CT) was available from diagnosis, and an average of 6.3 CT scans with a median follow-up of 3\u00a0months (IQR: 2\u201320\u00a0months).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The average time from symptom onset to angiographic treatment initiation was 8.0\u2009\u00b1\u20094.71\u00a0days, preceded by anticoagulation with heparin from the time of diagnosis. Patients were treated with combination therapy involving endovascular thrombolysis, rheolytic thrombectomy, and balloon angioplasty via transjugular (<jats:italic>n<\/jats:italic>\u2009=\u20099, 75%) or percutaneous (<jats:italic>n<\/jats:italic>\u2009=\u20093, 25%) approaches. Thrombolysis was performed with an average recombinant tissue plasminogen activator (rt-PA) infusion duration of 2.75\u2009\u00b1\u20091.14\u00a0days and a total dose of 61.25\u2009\u00b1\u200918.48\u00a0mg rt-PA. Superior mesenteric vein (SMV) flow was initially restored almost completely in 58.3% and partially in 41.7% of patients. Complications observed were hepatic artery bleeding (<jats:italic>n<\/jats:italic>\u2009=\u20092, 16.7%), hepatic arteriovenous fistula (<jats:italic>n<\/jats:italic>\u2009=\u20091, 8.3%), hepatic parenchymal bleeding (<jats:italic>n<\/jats:italic>\u2009=\u20091, 8.3%), melena (<jats:italic>n<\/jats:italic>\u2009=\u20091, 8.3%), and nostril bleeding (<jats:italic>n<\/jats:italic>\u2009=\u20091, 8.3%). Two patients experienced worsening symptoms of post-intervention, leading to bowel resection revealing intestinal necrosis. SMV patency was almost complete in 25%, and partially in 25% of patients at follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Endovascular combination therapy with long-term thrombolysis and thrombectomy in patients with ASMVT demonstrated promising technical outcomes. In view of complications, individual indication for intervention needs to be confirmed in a multidisciplinary team.\n<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s42155-025-00558-7","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:30:00Z","timestamp":1747204200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endovascular management of acute superior mesenteric vein thrombosis: a retrospective study on thrombolysis outcomes"],"prefix":"10.1186","volume":"8","author":[{"given":"Nan","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Michael","family":"Mathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Loos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Merle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Gauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Boxberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Klauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Kauczor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-1921","authenticated-orcid":false,"given":"Osman","family":"\u00d6cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark O.","family":"Wielp\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"issue":"12","key":"558_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1097\/01.RVI.0000182156.71059.B7","volume":"16","author":"HS Kim","year":"2005","unstructured":"Kim HS, Patra A, Khan J, Arepally A, Streiff MB. 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