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Risk stratification was performed as per European Society of Cardiology (ESC) guidelines. Patient demographics, clinical status, and imaging on presentation, procedural details, and outcomes with a minimum follow-up period of 1\u00a0year were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-nine cases were performed in 76 patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976; mean age 52\u00a0years, range 7\u201386; male:female\u2009=\u200937:39). Fifty-four patients were high-risk, 16 intermediate-high and 7 intermediate-low risk (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200977 cases). 39% of high-risk and 22% of intermediate-risk cases had an absolute or relative contraindication to thrombolytic therapy. Seventeen percent of high-risk and 4% of intermediate-risk cases had a failed trial of systemic thrombolysis. 54% of high-risk and 78% of intermediate-risk cases had a failed trial of anticoagulation. There was a statistically significant reduction in the RV:LV ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and clot burden (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) following catheter intervention. Available echocardiographic data demonstrated a trend towards improving right heart strain. Bleeding events occurred in 18% of cases, with 79% being high-risk. There was a significant improvement in functional outcomes as per WHO functional status (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Catheter-directed thrombolysis under the guidance of a PERT is a safe and effective therapy and provides a valuable management option for patients who have a contraindication to systemic thrombolysis or have failed a trial of systemic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42155-026-00699-3","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:45:16Z","timestamp":1779248716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of catheter intervention for acute pulmonary emboli in a tertiary United Kingdom centre with an established Pulmonary Embolism Response Team (PERT)"],"prefix":"10.1186","volume":"9","author":[{"given":"Sajal","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayanan","family":"Thulasidasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Charles","family":"Booth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Lams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Breen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-1402","authenticated-orcid":false,"given":"Narayan","family":"Karunanithy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"issue":"9828","key":"699_CR1","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1016\/S0140-6736(11)61904-1","volume":"379","author":"SZ Goldhaber","year":"2012","unstructured":"Goldhaber SZ, Bounameaux H. 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