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While this overall conclusion is reasonable, its interpretation warrants careful scrutiny. In this commentary, key methodological and interpretative aspects relevant to the appraisal of this evidence base are examined, with particular attention to the application of the GRADE framework, clinical heterogeneity, outcome selection, and indirectness. It is proposed that inconsistent or insufficiently transparent application of methodological criteria may influence how results are interpreted and communicated, with potential implications for clinical decision-making. A cautious, consistent, and context-aware interpretation of the available evidence is essential to avoid both overstatement and undue dismissal of therapeutic effects in a complex and heterogeneous condition such as neuropathic pain.<\/jats:p>","DOI":"10.1186\/s42238-026-00448-2","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:18:07Z","timestamp":1779866287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Commentary: Methodological considerations in the interpretation of evidence on cannabis-based medicines for chronic neuropathic pain"],"prefix":"10.1186","volume":"8","author":[{"given":"Wellington","family":"Briques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Maria Russiano","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderbal Silva","family":"Aguiar Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"448_CR1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1212\/01.wnl.0000253187.66183.9c","volume":"68","author":"DI Abrams","year":"2007","unstructured":"Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology. 2007;68:515\u201321. https:\/\/doi.org\/10.1212\/01.wnl.0000253187.66183.9c.","journal-title":"Neurology"},{"key":"448_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012182.pub3","author":"G Ate\u015f","year":"2026","unstructured":"Ate\u015f G, Welsch P, Klose P, Phillips T, Lambers B, H\u00e4user W, Radbruch L. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2026. https:\/\/doi.org\/10.1002\/14651858.CD012182.pub3.","journal-title":"Cochrane Database Syst Rev"},{"key":"448_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/j.pain.0000000000000753","volume":"158","author":"R Baron","year":"2017","unstructured":"Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanp\u00e4\u00e4 M, Hansson P, H\u00fcllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice ASC, Segerdahl M, Serra J, Sindrup S, Sommer C, T\u00f6lle T, Vollert J, Treede RD, German Neuropathic Pain Research Network (DFNS), EUROPAIN Consortium, NEUROPAIN Consortium. Peripheral neuropathic pain: A mechanism-related organizing principle based on sensory profiles. Pain. 2017;158:261\u201372. https:\/\/doi.org\/10.1097\/j.pain.0000000000000753.","journal-title":"Pain"},{"key":"448_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jpain.2007.09.005","volume":"9","author":"RH Dworkin","year":"2008","unstructured":"Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain. 2008;9:105\u201321. https:\/\/doi.org\/10.1016\/j.jpain.2007.09.005.","journal-title":"J Pain"},{"key":"448_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","volume":"14","author":"NB Finnerup","year":"2015","unstructured":"Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanp\u00e4\u00e4 M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore RA, Raja SN, Rice ASC, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M. Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis. Lancet Neurol. 2015;14:162\u201373. https:\/\/doi.org\/10.1016\/S1474-4422(14)70251-0.","journal-title":"Lancet Neurol"},{"key":"448_CR6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ, GRADE Working Group. 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