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The analysis revealed the presence of sabinene, carene, limonene, and \u03b2-ocimene. The leaves volatile oil showed a remarkable inhibition against<jats:italic>S. aureus<\/jats:italic>(32\u2009\u00b1\u20090.01\u00a0mm) and<jats:italic>P. aeruginosa<\/jats:italic>(49\u2009\u00b1\u20090.01\u00a0mm) and it had a strong effect on the DNA, RNA, lipids, and protein biosynthesis in cells of<jats:italic>S. aureus<\/jats:italic>and had a strong effect on the lipids biosynthesis in cells of<jats:italic>P. aeruginosa<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results in this study suggested that<jats:italic>C. lemon<\/jats:italic>leaves could be beneficial in developing a novel antibiotic and studied its mode of action on the pathogenic microorganism\u2019s cells.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s42269-020-00446-1","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T16:03:03Z","timestamp":1605801783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Phytochemical constituents and antibacterial activity of Citrus lemon leaves"],"prefix":"10.1186","volume":"44","author":[{"given":"Mohsen","family":"Asker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souad E.","family":"El-gengaihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeda A.","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"446_CR1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","volume":"46","author":"F Bakkali","year":"2008","unstructured":"Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils\u2014a review. 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