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The following standard questionnaires were completed at baseline and throughout a 1-year follow-up: WPAI:RA, WALS, WLQ-25, EQ-5D-3\u2009L and SF-36. Clinical and demographic variables were also collected through interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 290 patients on baseline visit. Overall mean scores at baseline visit were: WPAI:RA (presenteeism)\u2009=\u200929.5% (SD\u2009=\u200928.8%); WPAI:RA (absenteeism)\u2009=\u20099.0% (SD\u2009=\u200923.2%); WPAI:RA (absenteeism and presenteeism)\u2009=\u20098.6% (SD\u2009=\u200922.6%); WALS\u2009=\u20099.0 (SD\u2009=\u20096.1); WLQ-25\u2009=\u20097.0% (SD\u2009=\u20095.1%); SF-36 Physical Scale\u2009=\u200939.1 (SD\u2009=\u200910.3) and Mental Scale\u2009=\u200945.4 (SD\u2009=\u200911.3); EQ-5D-3\u2009L VAS\u2009=\u200969.8 (SD\u2009=\u200920.4) and EQ-5D-3\u2009L index\u2009=\u20090.67 (SD\u2009=\u20090.23). Higher educational levels were associated with better results in WLQ-25, while previous orthopedic surgeries reduced absenteeism results of WPAI:RA and work limitations in WLQ-25. Higher disease duration was associated with decreased HRQoL. Intensification of disease activity was associated with decreased work productivity and HRQoL, except in WLQ-25. In the longitudinal analysis, worsening in disease activity was associated with a decrease in both work productivity and HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RA patients are dealing with workplace disabilities and limitations and loss in HRQoL, and multiple factors seems to be associated with this. Worsening of disease activity further decreased work productivity and HRQoL, stressing the importance of disease tight control.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s42358-019-0090-8","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T13:02:47Z","timestamp":1573304567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Burden of rheumatoid arthritis on patients\u2019 work productivity and quality of life"],"prefix":"10.1186","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-4533","authenticated-orcid":false,"given":"Ricardo Machado","family":"Xavier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-2354","authenticated-orcid":false,"given":"Cristiano Augusto Freitas","family":"Zerbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Feldman","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-0389","authenticated-orcid":false,"given":"Jorge Luis Alberto","family":"Morales-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Fernando Molina","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Arnaldo","family":"Duhau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Rodr\u00edguez","family":"Amado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Abello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1171-3519","authenticated-orcid":false,"given":"Maria Celina","family":"de la Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana P\u00e9rez","family":"D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Martin","family":"Biegun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa Silva","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-4219","authenticated-orcid":false,"given":"Cesar","family":"Ramos-Remus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,9]]},"reference":[{"key":"90_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrd1109","volume":"2","author":"JS Smolen","year":"2003","unstructured":"Smolen JS, Steiner G. 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