{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:07Z","timestamp":1791614947097,"version":"4.3.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Rheumatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>The aims of this article were to assess the prevalence of nephrolithiasis and the factors associated with nephrolithiasis in Brazilian patients with primary gout.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>One hundred twenty-three patients with primary gout were recruited from a tertiary referral hospital in S\u00e3o Paulo, Brazil. All patients underwent ultrasonography and had their clinical and laboratory characteristics assessed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>One hundred fifteen (93.5%) patients were male, with a mean age of 62.9\u2009\u00b1\u20099.4\u2009years. Twenty-three (18.7%) patients had asymptomatic nephrolithiasis (detected only by ultrasonography), 7 (6.0%) had symptomatic nephrolithiasis (detected by ultrasonography and a positive clinical history), and 13 (10.0%) had a history of kidney stones, but ultrasonography at evaluation did not show nephrolithiasis. Therefore, 35.0% of the patients had nephrolithiasis (detected either by ultrasonography and\/or a positive clinical history). Nephrolithiasis was associated with male gender (43 [100%] vs 72 [90%], <jats:italic>p<\/jats:italic>\u00a0=\u20090.049), the use of potassium citrate (13 [30.2%] vs 0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009\u00a00.001) and the use of medications for diabetes (10 [23.3%] vs 8 [10%], <jats:italic>p<\/jats:italic>\u00a0=\u20090.047) and dyslipidemia (15 [34.9%] vs 10 [12.5%], <jats:italic>p<\/jats:italic>\u00a0=\u20090.003); benzbromarone had an inverse association with nephrolithiasis (21 [48.8%] vs 55 [68.8%], <jats:italic>p<\/jats:italic>\u00a0=\u20090.030). In patients with and without nephrolithiasis, no differences were found in the laboratory and ultrasonography characteristics, including serum uric acid levels, urinary uric acid excretion and urine pH.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The prevalence of nephrolithiasis in primary gout was 35.0%, and 18.7% of the patients were asymptomatic. Nephrolithiasis was associated with male gender, diabetes and dyslipidemia. A positive history of nephrolithiasis probably biased the prescription of potassium citrate and benzbromarone.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s42358-019-0106-4","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T15:02:51Z","timestamp":1577804571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nephrolithiasis in gout: prevalence and characteristics of Brazilian patients"],"prefix":"10.1186","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-4796","authenticated-orcid":false,"given":"Leonardo Santos","family":"Hoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Goldenstein-Schainberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"issue":"2","key":"106_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.rdc.2014.01.001","volume":"40","author":"E Roddy","year":"2014","unstructured":"Roddy E, Choi HK. 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