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To comprehensively evaluate the influence of <jats:italic>KIR<\/jats:italic> polymorphisms on the risk of SSc, this meta-analysis was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A systematic literature search was performed in electronic databases including Scopus and PubMed\/MEDLINE to find all available studies involving <jats:italic>KIR<\/jats:italic> gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between <jats:italic>KIR<\/jats:italic> gene family polymorphisms and SSc risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five articles, comprising 571 patients and 796 healthy participants, evaluating the <jats:italic>KIR<\/jats:italic> gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 <jats:italic>KIR<\/jats:italic> genes were assessed. None of the KIR genes were significantly associated with the risk of SSc.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s42358-019-0107-3","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T16:02:59Z","timestamp":1578672179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis"],"prefix":"10.1186","volume":"60","author":[{"given":"Elham","family":"Karimizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Mostafaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Aslani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Gharibdoost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Machado","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Hartstein","family":"Salim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda","family":"Kavosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Farhadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"107_CR1","doi-asserted-by":"publisher","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","volume":"1","author":"Y Allanore","year":"2015","unstructured":"Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, et al. 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