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In recent years, repetitive transcranial magnetic stimulation (rTMS) has been recommended for pain relief in various chronic pain disorders. The objective of the\u00a0present research was to study the effect of low frequency rTMS over the\u00a0right dorsolateral prefrontal cortex (DLPFC) on pain status in FMS.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Ninety diagnosed cases of FMS were randomized into\u00a0Sham-rTMS and Real-rTMS groups. Real rTMS (1\u2009Hz\/1200 pulses\/8 trains\/90% resting motor threshold) was delivered over\u00a0the right DLPFC for 5 consecutive days\/week for\u00a04\u2009weeks. Pain was assessed by\u00a0subjective and objective methods along with oxidative stress markers. Patients were followed up for 6\u2009months (post-rTMS;15\u2009days, 3\u2009months and 6\u2009months).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In Real-rTMS group, average pain ratings and associated symptoms showed significant improvement post rTMS. The beneficial effects of rTMS lasted up to 6\u2009months in the\u00a0follow-up phase. In Sham-rTMS group, no significant change in pain ratings was observed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Right DLPFC rTMS can significantly reduce pain and associated symptoms of FMS probably through targeting spinal pain circuits and top-down pain modulation .<\/jats:p>\n<jats:p>Trial registration: Ref No: CTRI\/2013\/12\/004228.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s42358-020-00135-7","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T11:02:59Z","timestamp":1593428579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Repetitive transcranial magnetic stimulation of the prefrontal cortex for fibromyalgia syndrome: a randomised controlled trial with 6-months follow up"],"prefix":"10.1186","volume":"60","author":[{"given":"Suman","family":"Tanwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Mattoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-5281","authenticated-orcid":false,"given":"Renu","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"issue":"10","key":"135_CR1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.medcli.2017.06.008","volume":"149","author":"A Cabo","year":"2017","unstructured":"Cabo A, Cerd\u00e1 G, Trillo J. 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Brain Stimul. 2015;8(5):965\u201373.","journal-title":"Brain Stimul"}],"container-title":["Advances in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42358-020-00135-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42358-020-00135-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42358-020-00135-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T23:11:45Z","timestamp":1624921905000},"score":1,"resource":{"primary":{"URL":"https:\/\/advancesinrheumatology.biomedcentral.com\/articles\/10.1186\/s42358-020-00135-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["135"],"URL":"https:\/\/doi.org\/10.1186\/s42358-020-00135-7","relation":{},"ISSN":["2523-3106"],"issn-type":[{"value":"2523-3106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"10 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted at the Pain Research and TMS Laboratory, Department of Physiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India. Human Ethics committee of the AIIMS, New Delhi (Ref No: IESC\/T-251\/15.06.2013) approved the research protocol in 2013. The study was also registered in ICMR-CTRI; India (Ref No: CTRI\/2013\/12\/004228). All procedures performed during study involving human participants were in accordance with the ethical standards of the Human Ethics committee of the AIIMS, New Delhi. All the participants provided written informed consent. All the participants were enrolled only after getting ethical approval.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent to publish was also obtained from all the participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors declare no competing interests concerning the work reported in this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"34"}}