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There is also scant information on the predictors of QoL in this population. The aim of this study was to assess QoL in patients with pSS and to investigate their possible predictors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a cross-sectional study, 77 patients with pSS were evaluated using the following questionnaires: Functional Assessment of Chronic Illness Therapy Fatigue Subscale (FACIT-Fatigue), EULAR Sj\u00f6gren\u2019s Syndrome Patient Reported Index (ESSPRI), EULAR Sj\u00f6gren\u2019s Syndrome Disease Activity Index (ESSDAI), Short Form-36 Health Survey (SF-36) and World Health Organization Quality of Life Assessment (WHOQOL-BREF). Seventy-seven healthy controls responded to the SF-36 and WHOQOL-BREF. The Mann-Whitney test, t-test, Pearson and Spearman correlation, and multiple regression analysis were used in the statistical analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with pSS and healthy controls were matched by gender and age. The mean scores for the ESSDAI, ESSPRI and FACIT-Fatigue were 3.34\u2009\u00b1\u20094.61, 6.58\u2009\u00b1\u20092.29 and 26.17\u2009\u00b1\u200911.02, respectively. Patients had a lower employment rate (36.4% versus 62.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01) and higher work disability (10.4% versus 1.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01). SF-36 and WHOQOL-BREF values were lower in patients with pSS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), except in the WHOQOL-BREF environment domain. Pain (ESSPRI), fatigue (FACIT-Fatigue), antinuclear antibody (ANA), anti-Ro-SSA and economic class (Brazilian Economic Classification Criteria - CCEB) were independent predictors of QoL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The main predictors of poor QoL in patients with pSS were pain and fatigue, and these symptoms had an impact regardless of disease activity, age, schooling, marital status, work disability and fibromyalgia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s42358-021-00181-9","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T09:06:52Z","timestamp":1622279212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pain and fatigue are predictors of quality of life in primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1186","volume":"61","author":[{"given":"Laiza Hombre","family":"Dias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira Tatiyama","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Alto\u00e9","family":"Giovelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caer\u00ea Iamonde Maciel","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-1308","authenticated-orcid":false,"given":"Valeria","family":"Valim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"issue":"3","key":"181_CR1","first-page":"3","volume":"37 Suppl 118","author":"G Cafaro","year":"2019","unstructured":"Cafaro G, et al. 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