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This manuscript presents the protocol and preliminary findings of the Brazilian Registry on Sj\u00f6gren\u2019s Disease (BRAS), a national, prospective cohort supported by the Brazilian Society of Rheumatology (SBR). BRAS aims to collect comprehensive data on patients with Sj\u00f6gren\u2019s Disease (SjD) who meet the 2002 AECG and\/or 2016 ACR-EULAR classification criteria, fostering high-quality research initiatives. Data collection is conducted via REDCap and includes demographic, laboratory, and clinical parameters such as disease activity (ESSDAI), damage (SSDDI), comorbidities, cardiovascular risk (Framingham score), labial salivary gland biopsy, salivary gland ultrasound, and therapeutic approaches. Patient-reported outcome measures (PROMs) include ESSPRI, PROFAD, HADS, ESE, IPAQ-SF, and EQ-5D. To date, 1,082 patients have been enrolled (mean age 55.3\u2009\u00b1\u200913.3 years; 96.6% women). Major findings include xerostomia (93%), xerophthalmia (92%), positive lip biopsy (83.6%), anti-Ro\/SSA antibodies (77%), anti-La\/SSB (43%), systemic manifestations (71.3%, ESSDAI 4.8\u2009\u00b1\u20095.8), and organ damage (86.9%, SSDDI 2.3\u2009\u00b1\u20091.6). Average disease duration was 7\u2009\u00b1\u20096.3 years with a diagnostic delay of 3.7 years. Treatments included corticosteroids (18%), hydroxychloroquine (46%), immunosuppressants (38%), and rituximab (6.5%). Common comorbidities were hypertension (34.9%), obesity (30.2%), dyslipidemia (29.7%), fibromyalgia (26%), osteoarthritis (24%), hypothyroidism (23.6%), diabetes (12.9%), and cancer (12.7%). Patients reported high symptom burden (ESSPRI 5.4\u2009\u00b1\u20092.4), anxiety (48%), depression (40%), low quality of life (63.6\u2009\u00b1\u200922.2), and insufficient physical activity (only 32.7% exercised regularly). Findings highlight the need for a multidisciplinary care program. The findings reveal diagnostic delays, limited healthcare access, high symptom burden, systemic involvement, poor mental health and highlight the need for a multidisciplinary care program. The next phase involves establishing a biorepository for biological samples.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical trial number<\/jats:bold>\n                    Not applicable.\n                  <\/jats:p>","DOI":"10.1186\/s42358-025-00481-4","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:01:28Z","timestamp":1761562888000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brazilian Registry of Sj\u00f6gren\u2019s Disease (BRAS): a full picture of Sj\u00f6gren\u2019s disease in Brazil"],"prefix":"10.1186","volume":"65","author":[{"given":"Val\u00e9ria","family":"Valim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Tatiyama 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