{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:42:58Z","timestamp":1782398578851,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100030774","name":"Sociedade Brasileira de Reumatologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Rheumatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oxidative stress and inflammation contribute to telomere length (TL) attrition, a hallmark of cellular senescence. Systemic lupus erythematosus (SLE) is associated with premature cellular aging; however, the clinical relevance of TL shortening remains unclear. This study aimed to compare the relative TL of SLE patients and healthy controls and explore its association with clinical features and disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study including adult SLE patients and age- and sex-matched healthy controls (18\u201360 years). Demographic and clinical data were collected, and TL was measured using quantitative polymerase chain reaction (qPCR). Among SLE patients, disease activity, cumulative damage, fatigue, depression, anxiety, stress, and physical activity were also assessed. Statistical analyses included descriptive statistics, Student\u2019s t-test or Mann-Whitney test for group comparisons, Spearman\u2019s correlation, and multiple linear regression models selected based on the lowest Akaike information criterion (AIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty SLE patients (37 years\u2009\u00b1\u200911.5) and 55 controls (38 years\u2009\u00b1\u200910.5) were enrolled. SLE patients exhibited significantly shorter TL [median (IQR): 0.80 (0.29\u20132.94)] compared to controls [1.07 (0.38\u20132.32);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005]. In multivariate analysis, moderate anxiety was associated with shorter TL compared to none\/low anxiety [\u03b2= -0.353 (95%CI: -0.645; -0.061);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019]. An alternative model indicated that moderate stress was also associated with reduced TL [\u03b2= -0.411 (95%CI: -0.771; -0.050);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026]. No significant associations were found between TL and disease activity or cumulative damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SLE patients presented significantly shorter telomeres than healthy controls, with anxiety and stress symptoms contributing to TL attrition. Longitudinal studies are warranted to elucidate the clinical implications of TL shortening in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42358-025-00510-2","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T03:19:16Z","timestamp":1765941556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shortened telomere length, anxiety and psychological stress in systemic lupus erythematosus: a cross-sectional study"],"prefix":"10.1186","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-1115","authenticated-orcid":false,"given":"Anna Carolina Faria Moreira Gomes","family":"Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4510-3300","authenticated-orcid":false,"given":"Carolina Ruas Freire","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-3292","authenticated-orcid":false,"given":"J\u00e9ssica Martins","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-3850","authenticated-orcid":false,"given":"Ivonne Carolina Bola\u00f1os","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-7895","authenticated-orcid":false,"given":"Daniela Valad\u00e3o Freitas","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-4639","authenticated-orcid":false,"given":"Marco Aur\u00e9lio","family":"Romano-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-9377","authenticated-orcid":false,"given":"Maria Aparecida Camargos","family":"Bicalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-7261","authenticated-orcid":false,"given":"Gilda Aparecida","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-7493","authenticated-orcid":false,"given":"Adriana Maria","family":"Kakehasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"issue":"3","key":"510_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/0961203316662721","volume":"26","author":"YH Lee","year":"2017","unstructured":"Lee YH, Jung JH, Seo YH, Kim JH, Choi SJ, Ji JD, et al. 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