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Potential differences in demographic characteristics, clinical presentation, laboratory findings, and treatments approaches across age groups, remain poorly explored. To the best of our knowledge, no multicenter study in Latin America has systematically addressed these features. We aimed to assess demographic, clinical and laboratory features, and treatments in children\n                      <jats:italic>versus<\/jats:italic>\n                      adolescents with (IgAV)\/ (HSP) in a large multicenter study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter study involving four tertiary centers evaluated 687 children and adolescents (\u2264\u200918 years-old) with IgAV\/HSP (EULAR\/PRINTO\/PRES classification criteria) at first 3 months after diagnosis. The charts were retrospectively assessed for demographic data, initial clinical manifestations, laboratory tests and treatments. Data were compared between children (&lt;\u200910 years-old) and adolescents (\u2265\u200910 years-old), according to WHO definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IgAV\/HSP was diagnosed in 599\/687(87%) children [5.33(0.88\u20139.91) years-old] and 88\/687(13%) adolescents [11.33(10-17.5) years-old]. The median duration of purpura\/petechiae was significantly lower in children compared to adolescents [14(1-120) vs. 15(2\u201390) days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04]. The frequency of persistent purpura\/petechiae (\u2265\u20096 weeks of duration) was significantly reduced in the former group (7.2% vs. 19.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), likewise the frequency of gastrointestinal bleeding (17% vs. 34.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and proteinuria (49.7% vs. 84%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In contrast, the frequencies of arthritis\/arthralgia (82.7% vs. 73%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and orchitis(16.6% vs. 4.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) were significantly higher in children. Further analysis of laboratory tests showed that the median value of serum IgA was significantly lower in children than in adolescents [179.1(40-1002.0) vs. 279.0(104.0-488.0) mg\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01], whereas thrombocytosis was higher (40.1% vs. 23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Logistic regression demonstrated that persistent purpura\/petechiae after IgAV\/HSP diagnosis (OR\u2009=\u200918.337; 95%CI 1.245-270.137;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) was the only independently associated variable with dependent variable (adolescent).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large multicenter cohort, IgAV\/HSP onset occurred rarely at adolescence, with a more prominent cutaneous involvement. Prolonged purpura\/petechiae after IgAV\/HSP diagnosis was associated with adolescent-onset IgAV\/HSP, reinforcing the need for vigilant monitoring in this subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42358-025-00516-w","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:04:38Z","timestamp":1770887078000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prolonged skin involvement distinguishes adolescent from childhood-onset IgA vasculitis: a large multicenter study with 687 patients"],"prefix":"10.1186","volume":"66","author":[{"given":"Luisa Fernanda Caro","family":"Forero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Santana","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Nobrega","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Ribeiro","family":"Doria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Dur\u00e1n","family":"Cordoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Vineyard","family":"Steuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Santos","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia Costa Lima","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel Mantovani","family":"Buscatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleice Clemente Souza","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Terreri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Siqueira","family":"Dantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco H. 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The Institutional Ethical Board of HCFMUSP [Comiss\u00e3o de \u00c9tica para An\u00e1lise de Projetos de Pesquisa (CAPPesq)] approved the study (number 70992423.8.1001.0068), as well as the other participating centers.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required. The need for informed consent was waived by the local ethics committees of the participating centers due to the retrospective nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}