{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:48:15Z","timestamp":1767916095185,"version":"3.49.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol. Res. Pract."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti-glial nuclear antibody (AGNA) is an onconeuroal antibody targeting the nuclei of Bergmann glia in the cerebellum and Anti-SRY-related HMG-box\u00a01 (SOX1). It is highly specific for small cell lung cancer (SCLC) and correlates to the appearance of paraneoplastic neurological syndromes such as Lambert-Eaton myasthenic syndrome (pLEMS) and paraneoplastic cerebellar degeneration (PCD) amongst others. Herein, we present a SCLC patient with rapidly progressive PCD, LEMS and axonal polyneuropathy associated with AGNA\/SOX1-antibodies, successfully treated with plasma-exchange (PLEX).<\/jats:p>","DOI":"10.1186\/s42466-021-00129-w","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T06:02:28Z","timestamp":1621836148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA\/anti-SOX1 and VGCC antibodies"],"prefix":"10.1186","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-4854","authenticated-orcid":false,"given":"Jonas","family":"Feldheim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Glas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Kleinschnitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hagenacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"1-2","key":"129_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jneuroim.2005.03.020","volume":"165","author":"F Graus","year":"2005","unstructured":"Graus, F., Vincent, A., Pozo-Rosich, P., Sabater, L., Saiz, A., Lang, B., & Dalmau, J. (2005). Anti-glial nuclear antibody: Marker of lung cancer-related paraneoplastic neurological syndromes. Journal of Neuroimmunology, 165(1-2), 166\u2013171. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.03.020.","journal-title":"Journal of Neuroimmunology"},{"issue":"1-2","key":"129_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jneuroim.2013.05.003","volume":"261","author":"E Mart\u00edn-Garc\u00eda","year":"2013","unstructured":"Mart\u00edn-Garc\u00eda, E., Mannara, F., Guti\u00e9rrez-Cuesta, J., Sabater, L., Dalmau, J., Maldonado, R., & Graus, F. (2013). Intrathecal injection of P\/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. Journal of Neuroimmunology, 261(1-2), 53\u201359. https:\/\/doi.org\/10.1016\/j.jneuroim.2013.05.003.","journal-title":"Journal of Neuroimmunology"},{"key":"129_CR3","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3988\/jcn.2020.16.4.530","volume":"16","author":"X Sun","year":"2020","unstructured":"Sun, X., Tan, J., Sun, H., et al. (2020). Anti-SOX1 Antibodies in Paraneoplastic Neurological Syndrome. J Clin Neurol, 16, 530\u2013546.","journal-title":"J Clin Neurol"},{"issue":"1-2","key":"129_CR4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jneuroim.2010.07.005","volume":"226","author":"M Tschernatsch","year":"2010","unstructured":"Tschernatsch, M., Singh, P., Gross, O., Gerriets, T., Kneifel, N., Probst, C., \u2026 Blaes, F. (2010). Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy. Journal of Neuroimmunology, 226(1-2), 177\u2013180. https:\/\/doi.org\/10.1016\/j.jneuroim.2010.07.005.","journal-title":"Journal of Neuroimmunology"},{"issue":"1","key":"129_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2174\/1570159X16666180917105033","volume":"17","author":"H Mitoma","year":"2019","unstructured":"Mitoma, H., Manto, M., & Hampe, C. S. (2019). Immune-mediated cerebellar ataxias: Practical guidelines and therapeutic challenges. Current Neuropharmacology, 17(1), 33\u201358. https:\/\/doi.org\/10.2174\/1570159X16666180917105033.","journal-title":"Current Neuropharmacology"},{"issue":"11","key":"129_CR6","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/3315","volume":"4","author":"ML Albert","year":"1998","unstructured":"Albert, M. L., Darnell, J. C., Bender, A., Francisco, L. M., Bhardwaj, N., & Darnell, R. B. (1998). Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nature Medicine, 4(11), 1321\u20131324. https:\/\/doi.org\/10.1038\/3315.","journal-title":"Nature Medicine"},{"key":"129_CR7","doi-asserted-by":"crossref","unstructured":"Vogrig, A., Mu\u00f1iz-Castrillo, S., Desestret, V., Joubert, B., & Honnorat, J. (2020). Pathophysiology of paraneoplastic and autoimmune encephalitis: Genes, infections, and checkpoint inhibitors. Therapeutic Advances in Neurological Disorders, 13, 1756286420932797.","DOI":"10.1177\/1756286420932797"}],"container-title":["Neurological Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-021-00129-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42466-021-00129-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-021-00129-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T06:03:05Z","timestamp":1621836185000},"score":1,"resource":{"primary":{"URL":"https:\/\/neurolrespract.biomedcentral.com\/articles\/10.1186\/s42466-021-00129-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["129"],"URL":"https:\/\/doi.org\/10.1186\/s42466-021-00129-w","relation":{},"ISSN":["2524-3489"],"issn-type":[{"value":"2524-3489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,24]]},"assertion":[{"value":"24 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent aquired.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30"}}