{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:24:31Z","timestamp":1760300671402,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol. Res. Pract."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) primarily leading to venous thromboses. Here, we report two cases of major arterial occlusions after ChAdOx1 nCov-19 vaccination, comprising a 42-year-old woman with thrombotic occlusion of the left carotid artery, and a 62-year-old man with occlusion of distal aorta and iliac arteries. Both were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents leading to a beneficial short-term outcome of 6\u00a0weeks in case 1 and four months in case 2.<\/jats:p>","DOI":"10.1186\/s42466-021-00151-y","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T17:03:51Z","timestamp":1633367031000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination"],"prefix":"10.1186","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-8231","authenticated-orcid":false,"given":"Yasemin","family":"Goereci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina N.","family":"Kleineberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Madlener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Neuschmelting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Warnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Stetefeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"151_CR1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840","author":"A Greinacher","year":"2021","unstructured":"Greinacher, A., Thiele, T., Warkentin, T. E., Weisser, K., Kyrle, P. A., & Eichinger, S. (2021). Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. The New England Journal of Medicine. https:\/\/doi.org\/10.1056\/NEJMoa2104840","journal-title":"The New England Journal of Medicine"},{"key":"151_CR2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104882","author":"NH Schultz","year":"2021","unstructured":"Schultz, N. H., S\u00f8rvoll, I. H., Michelsen, A. E., Munthe, L. A., Lund-Johansen, F., Ahlen, M. T., Wiedmann, M., Aamodt, A. H., Skatt\u00f8r, T. H., Tj\u00f8nnfjord, G. E., & Holme, P. A. (2021). Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. The New England Journal of Medicine. https:\/\/doi.org\/10.1056\/NEJMoa2104882","journal-title":"The New England Journal of Medicine"},{"key":"151_CR3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105385","author":"M Scully","year":"2021","unstructured":"Scully, M., Singh, D., Lown, R., Poles, A., Solomon, T., Levi, M., Goldblatt, D., Kotoucek, P., Thomas, W., & Lester, W. (2021). Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. The New England Journal of Medicine. https:\/\/doi.org\/10.1056\/NEJMoa2105385","journal-title":"The New England Journal of Medicine"},{"key":"151_CR4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011958","author":"A Tiede","year":"2021","unstructured":"Tiede, A., Sachs, U. J., Czwalinna, A., Werwitzke, S., Bikker, R., Krauss, J. K., Donnerstag, F. G., Wei\u00dfenborn, K., H\u00f6glinger, G. U., Maasoumy, B., Wedemeyer, H., & Ganser, A. (2021). Prothrombotic immune thrombocytopenia after COVID-19 vaccine. Blood. https:\/\/doi.org\/10.1182\/blood.2021011958","journal-title":"Blood"},{"key":"151_CR5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2106315","author":"DB Cines","year":"2021","unstructured":"Cines, D. B., & Bussel, J. B. (2021). SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. The New England Journal of Medicine. https:\/\/doi.org\/10.1056\/NEJMe2106315","journal-title":"The New England Journal of Medicine"},{"key":"151_CR6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279000","author":"K Althaus","year":"2021","unstructured":"Althaus, K., M\u00f6ller, P., Uzun, G., Singh, A., Beck, A., Bettag, M., B\u00f6sm\u00fcller, H., Guthoff, M., Dorn, F., Petzold, G. C., Henkes, H., Heyne, N., Jumaa, H., Kreiser, K., Limpach, C., Luz, B., Maschke, M., M\u00fcller, J. A., M\u00fcnch, J., \u2026 Bakchoul, T. (2021). Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica. https:\/\/doi.org\/10.3324\/haematol.2021.279000","journal-title":"Haematologica"},{"key":"151_CR7","doi-asserted-by":"publisher","DOI":"10.7326\/l21-0244","author":"S Sangli","year":"2021","unstructured":"Sangli, S., Virani, A., Cheronis, N., Vannatter, B., Minich, C., Noronha, S., Bhagavatula, R., Speredelozzi, D., Sareen, M., & Kaplan, R. B. (2021). Thrombosis with thrombocytopenia after the messenger RNA-1273 vaccine. Annals of Internal Medicine. https:\/\/doi.org\/10.7326\/l21-0244","journal-title":"Annals of Internal Medicine"},{"key":"151_CR8","doi-asserted-by":"publisher","first-page":"102681","DOI":"10.1016\/j.jaut.2021.102681","volume":"122","author":"J Hwang","year":"2021","unstructured":"Hwang, J., Lee, S. B., Lee, S. W., Lee, M. H., Koyanagi, A., Jacob, L., Tizaoui, K., Yon, D. K., Shin, J. I., & Smith, L. (2021). Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines. Journal of Autoimmunity, 122, 102681. https:\/\/doi.org\/10.1016\/j.jaut.2021.102681","journal-title":"Journal of Autoimmunity"}],"container-title":["Neurological Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-021-00151-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42466-021-00151-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-021-00151-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T17:03:54Z","timestamp":1633367034000},"score":1,"resource":{"primary":{"URL":"https:\/\/neurolrespract.biomedcentral.com\/articles\/10.1186\/s42466-021-00151-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["151"],"URL":"https:\/\/doi.org\/10.1186\/s42466-021-00151-y","relation":{},"ISSN":["2524-3489"],"issn-type":[{"type":"electronic","value":"2524-3489"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"24 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written Informed consent was obtained from both participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"C.W. has received institutional support from Novartis, Biogen, Alexion, Janssen, and Roche. None related to this study. No other disclosures were reported.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"52"}}