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Antecedent infections have been seen to be significant triggering factors for developing GBS. Among them, arboviral infections are rapidly gaining importance as significant triggers, especially in the areas where they are endemic. Chikungunya, an arboviral infection that usually causes a self-limiting acute febrile illness can lead to GBS as one its severe complications. Herein, we describe a case of a 21-year-old female who presented with weakness in all four limbs and paresthesia. Nerve conduction study and cerebrospinal fluid (CSF) analysis showed axonal, demyelinating motor and sensory neuropathy with albuminocytological dissociation indicating Acute Motor and Sensory Axonal Neuropathy (AMSAN) variant of GBS. Serum IgM antibodies against ganglioside GM1 were detected. Anti-Chikungunya IgM antibodies were found in both serum and CSF samples. The patient was initiated with Intravenous Immunoglobulin (IVIG) therapy. In view of hypoxia, she was intubated and was on mechanical ventilation. After 2 weeks of being comatose, the patient gradually improved and was discharged with no sequelae.<\/jats:p><jats:p>A literature review on antecedent infections in GBS is presented alongside the case report to better understand the association of GBS with antecedent infections, especially the endemic arboviral infections like Chikungunya, Dengue and Zika. This will help in reinforcing the significance of having robust surveillance and public health control measures for infectious diseases.<\/jats:p>","DOI":"10.1186\/s42466-024-00315-6","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:01:53Z","timestamp":1712793713000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Guillain-barr\u00e9 syndrome (GBS) with antecedent chikungunya infection: a case report and literature review"],"prefix":"10.1186","volume":"6","author":[{"given":"Sreelakshmi","family":"V.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-0347","authenticated-orcid":false,"given":"Amrita","family":"Pattanaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilatha","family":"Marate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeta S","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna R.","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiranjay","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"1","key":"315_CR1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12974-021-02319-4","volume":"18","author":"NL Bragazzi","year":"2021","unstructured":"Bragazzi, N. 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Incidence of Guillain-Barr\u00e9 syndrome (GBS) in China: A national population-based study. The Lancet Regional Health Western Pacific, 18, 100302. https:\/\/doi.org\/10.1016\/j.lanwpc.2021.100302.","journal-title":"The Lancet Regional Health Western Pacific"},{"issue":"5","key":"315_CR4","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/ene.13569","volume":"25","author":"N Matsui","year":"2018","unstructured":"Matsui, N., Nodera, H., Kuzume, D., Iwasa, N., Unai, Y., et al. (2018). Guillain-Barr\u00e9 syndrome in a local area in Japan, 2006\u20132015: An epidemiological and clinical study of 108 patients. 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