{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:12:47Z","timestamp":1793074367395,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"},{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol. Res. Pract."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endovascular treatment (ET) options for acute stroke due to distal middle cerebral artery occlusions are rapidly evolving, but data on outcome and safety are sparse. We therefore performed an analysis of patients undergoing ET for primary M3 occlusions in routine clinical practice in a nationwide registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients enrolled between 01\/20 and 12\/21 in the prospective, multicenter German Stroke Registry-Endovascular Treatment (GSR-ET) were screened for mechanical thrombectomy performed for primary M3 occlusion. We analyzed neurological deficit as measured by the National Institute of Health Stroke Scale (NIHSS), symptomatic intracranial hemorrhage (sICH), thrombectomy technique, successful reperfusion (modified Thrombolysis in Cerebral Infarction [mTICI] score of 2b-3) and functional outcome as measured by the modified Rankin Scale (mRS) at discharge and 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 5574 patients, 11 patients (0.2%, median age 80 years, 54.5% female) underwent ET for primary M3 occlusion. All patients had pre-admission mRS\u2009\u2264\u20091, median NIHSS on admission was 8, and successful reperfusion was achieved in 6\/11 patients (54.5%). While no vasospasm, dissection or perforation was reported, symptomatic intracranial hemorrhage occurred in 2 patients (18.2%). Favorable outcome (mRS\u2009\u2264\u20092) was achieved in 6\/11 patients (54.5%) at 90-day follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ET for primary M3 occlusions is rarely performed. While technically feasible, the procedure\u2019s potential benefits must be carefully weighed against its associated risks, including clinically relevant complications. Caution and further research is needed to optimize patient selection for this intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>GSR-ET; ClinicalTrials.gov Identifier: NCT03356392; Trial Registration Date: 11\/29\/2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42466-024-00330-7","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T20:02:21Z","timestamp":1721246541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry"],"prefix":"10.1186","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-369X","authenticated-orcid":false,"given":"Niklas M.","family":"Beckonert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Alegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Boeckh-Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milani","family":"Deb-Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars U.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils C.","family":"Lehnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Tiedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Zweynert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor C.","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the GSR-ET investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Berrouschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bohner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bormann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Ernemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MS","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fiehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gerloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gr\u00f6schel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hattingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KH","family":"Henn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Keil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kellert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Liman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Muehl-Benninghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Nikoubashman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"R\u00f6ther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JH","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Schellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"St\u00f6gbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Thomalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Trumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Uphaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"10029","key":"330_CR1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/s0140-6736(16)00163-x","volume":"387","author":"M Goyal","year":"2016","unstructured":"Goyal, M., Menon, B. K., Van Zwam, W. H., et al. (2016). Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet, 387(10029), 1723\u20131731. https:\/\/doi.org\/10.1016\/s0140-6736(16)00163-x","journal-title":"Lancet"},{"issue":"7","key":"330_CR2","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1136\/NEURINTSURG-2021-017321","volume":"13","author":"JM Ospel","year":"2021","unstructured":"Ospel, J. M., & Goyal, M. (2021). A review of endovascular treatment for medium vessel occlusion stroke. Journal of NeuroInterventional Surgery, 13(7), 623\u2013630. https:\/\/doi.org\/10.1136\/NEURINTSURG-2021-017321","journal-title":"Journal of NeuroInterventional Surgery"},{"issue":"15","key":"330_CR3","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.3390\/JCM11154619","volume":"11","author":"M Herzberg","year":"2022","unstructured":"Herzberg, M., Dorn, F., Trumm, C., et al. (2022). Middle cerebral artery M2 thrombectomy: safety and technical considerations in the German Stroke Registry (GSR). Journal of Clinical Medicine, 11(15), 4619. https:\/\/doi.org\/10.3390\/JCM11154619","journal-title":"Journal of Clinical Medicine"},{"issue":"5","key":"330_CR4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/ANA.26331","volume":"91","author":"A Sarraj","year":"2022","unstructured":"Sarraj, A., Parsons, M., Bivard, A., et al. (2022). Endovascular thrombectomy versus medical management in isolated M2 occlusions: pooled patient-level analysis from the EXTEND-IA Trials, INSPIRE, and SELECT Studies. Annals of Neurology, 91(5), 629\u2013639. https:\/\/doi.org\/10.1002\/ANA.26331","journal-title":"Annals of Neurology"},{"issue":"12","key":"330_CR5","doi-asserted-by":"publisher","first-page":"E344","DOI":"10.1161\/STR.0000000000000211","volume":"50","author":"WJ Powers","year":"2019","unstructured":"Powers, W. J., Rabinstein, A. A., Ackerson, T., et al. (2019). Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke, 50(12), E344\u2013E418. https:\/\/doi.org\/10.1161\/STR.0000000000000211","journal-title":"Stroke"},{"key":"330_CR6","doi-asserted-by":"publisher","unstructured":"Loh, E.D.W., Toh, K.Z.X., Kwok, G.Y.R., et al. (2022). Endovascular therapy for acute ischemic stroke with distal medium vessel occlusion: a systematic review and meta-analysis.\u00a0Journal of NeuroInterventional Surgery. 0:jnis-2022-019717. https:\/\/doi.org\/10.1136\/JNIS-2022-019717","DOI":"10.1136\/JNIS-2022-019717"},{"issue":"10346","key":"330_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0140-6736(22)00564-5","volume":"400","author":"PJ Mitchell","year":"2022","unstructured":"Mitchell, P. J., Yan, B., Churilov, L., et al. (2022). Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4\u00b75 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial. Lancet, 400(10346), 116\u2013125. https:\/\/doi.org\/10.1016\/S0140-6736(22)00564-5","journal-title":"Lancet"},{"key":"330_CR8","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1161\/STROKEAHA.120.028956","volume":"51","author":"JL Saver","year":"2020","unstructured":"Saver, J. L., Chapot, R., Agid, R., et al. (2020). Thrombectomy for distal, medium vessel occlusions. Stroke, 51, 2872\u20132884. https:\/\/doi.org\/10.1161\/STROKEAHA.120.028956","journal-title":"Stroke"},{"issue":"8","key":"330_CR9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1212\/WNL.0000000000002399","volume":"86","author":"R Lemmens","year":"2016","unstructured":"Lemmens, R., Hamilton, S. A., Liebeskind, D. S., et al. (2016). Effect of endovascular reperfusion in relation to site of arterial occlusion. Neurology, 86(8), 762. https:\/\/doi.org\/10.1212\/WNL.0000000000002399","journal-title":"Neurology"},{"issue":"7","key":"330_CR10","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1161\/strokeaha.118.020567","volume":"49","author":"JA Grossberg","year":"2018","unstructured":"Grossberg, J. A., Rebello, L. C., Haussen, D. C., et al. (2018). Beyond large vessel occlusion strokes: distal occlusion thrombectomy. Stroke, 49(7), 1662\u20131668. https:\/\/doi.org\/10.1161\/strokeaha.118.020567","journal-title":"Stroke"},{"issue":"4","key":"330_CR11","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1136\/NEURINTSURG-2019-015205","volume":"12","author":"DC Haussen","year":"2020","unstructured":"Haussen, D. C., Al-Bayati, A. R., Eby, B., et al. (2020). Blind exchange with mini-pinning technique for distal occlusion thrombectomy. Journal of NeuroInterventional Surgery, 12(4), 392\u2013395. https:\/\/doi.org\/10.1136\/NEURINTSURG-2019-015205","journal-title":"Journal of NeuroInterventional Surgery"},{"issue":"4","key":"330_CR12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1177\/1747493018806199","volume":"14","author":"AC Alegiani","year":"2019","unstructured":"Alegiani, A. C., Dorn, F., Herzberg, M., et al. (2019). Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment. International Journal of Stroke, 14(4), 372\u2013380. https:\/\/doi.org\/10.1177\/1747493018806199","journal-title":"International Journal of Stroke"},{"issue":"9","key":"330_CR13","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1161\/STROKEAHA.119.026005","volume":"50","author":"FA Wollenweber","year":"2019","unstructured":"Wollenweber, F. A., Tiedt, S., Alegiani, A., et al. (2019). Functional outcome following stroke thrombectomy in clinical practice. Stroke, 50(9), 2500\u20132506. https:\/\/doi.org\/10.1161\/STROKEAHA.119.026005","journal-title":"Stroke"},{"issue":"2","key":"330_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3171\/JNS.1981.54.2.0151","volume":"54","author":"H Gibo","year":"1981","unstructured":"Gibo, H., Carver, C. C., Rhoton, A. L., Lenkey, C., & Mitchell, R. J. (1981). Microsurgical anatomy of the middle cerebral artery. Journal of Neurosurgery, 54(2), 151\u2013169. https:\/\/doi.org\/10.3171\/JNS.1981.54.2.0151","journal-title":"Journal of Neurosurgery"},{"issue":"9","key":"330_CR15","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1161\/STROKEAHA.113.001972","volume":"44","author":"OO Zaidat","year":"2013","unstructured":"Zaidat, O. O., Yoo, A. J., Khatri, P., et al. (2013). Recommendations on angiographic revascularization grading standards for acute ischemic stroke. Stroke, 44(9), 2650\u20132663. https:\/\/doi.org\/10.1161\/STROKEAHA.113.001972","journal-title":"Stroke"},{"issue":"10","key":"330_CR16","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/STROKEAHA.115.010049","volume":"46","author":"R Von Kummer","year":"2015","unstructured":"Von Kummer, R., Broderick, J. P., Campbell, B. C. V., et al. (2015). The Heidelberg bleeding classification. Stroke, 46(10), 2981\u20132986. https:\/\/doi.org\/10.1161\/STROKEAHA.115.010049","journal-title":"Stroke"},{"issue":"2","key":"330_CR17","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1161\/01.STR.32.2.438","volume":"32","author":"V Larrue","year":"2001","unstructured":"Larrue, V., Von Kummer, R., M\u00fcller, A., & Bluhmki, E. (2001). Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator. Stroke, 32(2), 438\u2013441. https:\/\/doi.org\/10.1161\/01.STR.32.2.438","journal-title":"Stroke"},{"issue":"1","key":"330_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","volume":"24","author":"HP Adams","year":"1993","unstructured":"Adams, H. P., Bendixen, B. H., Kappelle, L. J., et al. (1993). Classification of subtype of acute ischemic stroke definitions for use in a multicenter clinical trial. Stroke, 24(1), 35\u201341. https:\/\/doi.org\/10.1161\/01.STR.24.1.35","journal-title":"Stroke"},{"issue":"1","key":"330_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S42466-023-00297-X\/FIGURES\/4","volume":"6","author":"MN Ungerer","year":"2024","unstructured":"Ungerer, M. N., Bartig, D., Richter, D., Krogias, C., Hacke, W., & Gumbinger, C. (2024). The evolution of acute stroke care in Germany from 2019 to 2021: Analysis of nation-wide administrative datasets. Neurological Research and Practice, 6(1), 1\u20138. https:\/\/doi.org\/10.1186\/S42466-023-00297-X\/FIGURES\/4","journal-title":"Neurological Research and Practice"},{"key":"330_CR20","doi-asserted-by":"publisher","unstructured":"Schulze-Zachau, V., Brehm, A., Ntoulias, N., et al. (2023). Incidence and outcome of perforations during medium vessel occlusion compared with large vessel occlusion thrombectomy.\u00a0Journal of NeuroInterventional Surgery. 0:jnis-2023\u2013020531. https:\/\/doi.org\/10.1136\/JNIS-2023-020531","DOI":"10.1136\/JNIS-2023-020531"},{"issue":"6","key":"330_CR21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/neurintsurg-2020-015807","volume":"12","author":"M Goyal","year":"2020","unstructured":"Goyal, M., Ospel, J. M., Menon, B. K., & Hill, M. D. (2020). The next frontier? Journal of NeuroInterventional Surgery, 12(6), 545\u2013547. https:\/\/doi.org\/10.1136\/neurintsurg-2020-015807","journal-title":"Journal of NeuroInterventional Surgery"},{"issue":"9","key":"330_CR22","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1161\/STROKEAHA.116.014181\/-\/DC1","volume":"47","author":"P Seners","year":"2016","unstructured":"Seners, P., Turc, G., Ma\u00efer, B., Mas, J. L., Oppenheim, C., & Baron, J. C. (2016). Incidence and predictors of early recanalization after intravenous thrombolysis: a systematic review and meta-analysis. Stroke, 47(9), 2409\u20132412. https:\/\/doi.org\/10.1161\/STROKEAHA.116.014181\/-\/DC1","journal-title":"Stroke"}],"container-title":["Neurological Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-024-00330-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42466-024-00330-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42466-024-00330-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T20:02:36Z","timestamp":1721246556000},"score":1,"resource":{"primary":{"URL":"https:\/\/neurolrespract.biomedcentral.com\/articles\/10.1186\/s42466-024-00330-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["330"],"URL":"https:\/\/doi.org\/10.1186\/s42466-024-00330-7","relation":{},"ISSN":["2524-3489"],"issn-type":[{"value":"2524-3489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]},"assertion":[{"value":"28 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and was centrally approved by the institutional review board of the Ludwig-Maximilians University Munich (689\u201315) and institutional review boards according to local regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"NMB received travel grants from Sanofi and Viatris. FD is a consultant\/proctor for Cerenovus\/Johnson&Johnson, Balt, Cerus Endovascular and Phenox. She received speaker's honoraria from Acandis, Stryker, Cerenovus\/Johnson&Johnson, Asahi and research support from Cerenovus\/Johnson&Johnson. MDC reports grants from the Werner Otto Stiftung outside the submitted the work. All other authors report no conflicting interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"36"}}