{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:12:45Z","timestamp":1752282765349,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Epileptologica"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Epilepsy secondary to acquired immunodeficiency syndrome (AIDS) can be challenging to manage. The potential interactions between antiretroviral drugs and antiepileptic drugs may result in the failure of both treatments. Therefore, it is crucial to develop more effective strategies to enhance the clinical outcomes of patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of epilepsy secondary to AIDS. After administration of Bacteroides Fragilis 839 (BF839), the secondary generalized tonic-clonic seizures disappeared, the frequency of complex partial seizures decreased by 70%, and the duration of each episode was shortened. Additionally,\u00a0long-term diarrhea associated with antiretroviral therapy for AIDS resolved, and the syphilis serofast reaction turned negative. No serious adverse reactions were observed during the three-year follow up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case report suggests that the specific gut microbiota preparation could possibly\u00a0improve refractory epilepsy in HIV patients while also potentially\u00a0alleviating adverse reactions to antiretroviral drugs and concurrent syphilis infection. Our case may\u00a0provide a new perspective for the treatment of HIV infection\/AIDS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s42494-024-00156-5","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:02:05Z","timestamp":1713139325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvement of epilepsy secondary to acquired immunodeficiency syndrome with intestinal microbiota preparations: a case report"],"prefix":"10.1186","volume":"6","author":[{"given":"Chuhui","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-553X","authenticated-orcid":false,"given":"Yuhong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"156_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.yebeh.2019.01.033","volume":"93","author":"P Ssentongo","year":"2019","unstructured":"Ssentongo P. Prevalence and incidence of new-onset seizures and epilepsy in patients with human immunodeficiency virus (HIV): Systematic review and meta-analysis. Epilepsy Behav. 2019;93:49\u201355.","journal-title":"Epilepsy Behav"},{"issue":"2","key":"156_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1212\/WNL.0b013e31823efcf8","volume":"78","author":"GL Birbeck","year":"2012","unstructured":"Birbeck GL, French JA, Perucca E, Simpson DM, Fraimow H, George J, et al. Evidence-based guideline: antiepileptic drug selection for people with HIV\/AIDS: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy. Neurology. 2012;78(2):139\u201345.","journal-title":"Neurology"},{"key":"156_CR3","first-page":"216","volume":"13","author":"JJ Zhang","year":"1991","unstructured":"Zhang JJ, Yu LX, Xu LZ, Wang WY, Zhang HJ, Pan ZH, et al. 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