{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:49:41Z","timestamp":1781322581830,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Epileptologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Mesial temporal lobe epilepsy (mTLE) is the most common form of focal epilepsy, often associated with hippocampal sclerosis. Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We used morphometric similarity network (MSN) analysis and the Allen Human Brain Atlas (AHBA) database to investigate structural changes between mTLE and healthy controls, as well as correlation with inflammation-related gene expression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We identified widespread alterations across the frontal and parietal lobes and cingulate cortex linked to neuroinflammatory genes such as <jats:italic>PRR5, SMAD3<\/jats:italic>, and <jats:italic>IRF3<\/jats:italic>. This correlation was even more pronounced in mTLE patients\u00a0with hippocampal sclerosis\u00a0compared to those without. Enrichment analysis highlighted pathways related to neurodevelopment and neurodegeneration, supporting a bidirectional link between mTLE and neurodegenerative diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These findings suggest that brain-wide macroscopic morphometric alternations in mTLE are correlated to the neuroinflammation process. It provides circumstantial evidence from a new perspective to support the bidirectional link between mTLE and neurodegenerative diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s42494-025-00208-4","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T02:22:01Z","timestamp":1741054921000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions"],"prefix":"10.1186","volume":"7","author":[{"given":"Lu","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-4125","authenticated-orcid":false,"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"issue":"1","key":"208_CR1","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/s41467-024-46629-6","volume":"15","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Li W, Li J, Li X, Zhang H, Sima X, et al. Identification of four biotypes in temporal lobe epilepsy via machine learning on brain images. Nat Commun. 2024;15(1):2221.","journal-title":"Nat Commun"},{"issue":"7","key":"208_CR2","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1111\/epi.12220","volume":"54","author":"I Bl\u00fcmcke","year":"2013","unstructured":"Bl\u00fcmcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, et al. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013;54(7):1315\u201329.","journal-title":"Epilepsia"},{"issue":"1","key":"208_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.neuron.2017.11.039","volume":"97","author":"J Seidlitz","year":"2018","unstructured":"Seidlitz J, V\u00e1\u0161a F, Shinn M, Romero-Garcia R, Whitaker KJ, V\u00e9rtes PE, et al. Morphometric similarity networks detect microscale cortical organization and predict inter-individual cognitive variation. Neuron. 2018;97(1):231-247.e7.","journal-title":"Neuron"},{"issue":"1","key":"208_CR4","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/s41467-021-21943-5","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Seidlitz J, Suckling J, Fan F, Ji GJ, Meng Y, et al. Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures. Nat Commun. 2021;12(1):1647.","journal-title":"Nat Commun"},{"issue":"19","key":"208_CR5","doi-asserted-by":"publisher","first-page":"9604","DOI":"10.1073\/pnas.1820754116","volume":"116","author":"SE Morgan","year":"2019","unstructured":"Morgan SE, Seidlitz J, Whitaker KJ, Romero-Garcia R, Clifton NE, Scarpazza C, et al. Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes. Proc Natl Acad Sci U S A. 2019;116(19):9604\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"208_CR6","doi-asserted-by":"publisher","first-page":"104847","DOI":"10.1016\/j.ebiom.2023.104847","volume":"97","author":"H Cao","year":"2023","unstructured":"Cao H, Wei P, Huang Y, Wang N, Guo LA, Fan X, et al. The alteration of cortical microstructure similarity in drug-resistant epilepsy correlated with mTOR pathway genes. eBioMedicine. 2023;97:104847.","journal-title":"eBioMedicine"},{"issue":"1","key":"208_CR7","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1038\/s41467-022-31730-5","volume":"13","author":"S Larivi\u00e8re","year":"2022","unstructured":"Larivi\u00e8re S, Royer J, Rodr\u00edguez-Cruces R, Paquola C, Caligiuri ME, Gambardella A, et al. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression. Nat Commun. 2022;13(1):4320.","journal-title":"Nat Commun"},{"issue":"12","key":"208_CR8","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1111\/epi.13225","volume":"56","author":"CL Yasuda","year":"2015","unstructured":"Yasuda CL, Chen Z, Beltramini GC, Coan AC, Morita ME, Kubota B, et al. Aberrant topological patterns of brain structural network in temporal lobe epilepsy. Epilepsia. 2015;56(12):1992\u20132002.","journal-title":"Epilepsia"},{"issue":"3","key":"208_CR9","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1148\/radiol.13131044","volume":"270","author":"MN DeSalvo","year":"2014","unstructured":"DeSalvo MN, Douw L, Tanaka N, Reinsberger C, Stufflebeam SM. Altered structural connectome in temporal lobe epilepsy. Radiology. 2014;270(3):842\u20138.","journal-title":"Radiology"},{"issue":"3","key":"208_CR10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/epi.16819","volume":"62","author":"N Sinha","year":"2021","unstructured":"Sinha N, Peternell N, Schroeder GM, de Tisi J, Vos SB, Winston GP, et al. Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy. Epilepsia. 2021;62(3):729\u201341.","journal-title":"Epilepsia"},{"issue":"1","key":"208_CR11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1186\/s12967-024-05580-2","volume":"22","author":"L Qin","year":"2024","unstructured":"Qin L, Zhou Q, Sun Y, Pang X, Chen Z, Zheng J. Dynamic functional connectivity and gene expression correlates in temporal lobe epilepsy: insights from hidden markov models. J Transl Med. 2024;22(1):763.","journal-title":"J Transl Med"},{"issue":"4","key":"208_CR12","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/epi.13670","volume":"58","author":"RS Fisher","year":"2017","unstructured":"Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522\u201330.","journal-title":"Epilepsia"},{"issue":"169","key":"208_CR13","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.neuroimage.2017.12.059","volume":"1","author":"AFG Rosen","year":"2018","unstructured":"Rosen AFG, Roalf DR, Ruparel K, Blake J, Seelaus K, Villa LP, et al. Quantitative assessment of structural image quality. Neuroimage. 2018;1(169):407\u201318.","journal-title":"Neuroimage"},{"issue":"4","key":"208_CR14","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1016\/j.neuroimage.2011.10.086","volume":"59","author":"R Romero-Garcia","year":"2012","unstructured":"Romero-Garcia R, Atienza M, Clemmensen LH, Cantero JL. Effects of network resolution on topological properties of human neocortex. Neuroimage. 2012;59(4):3522\u201332.","journal-title":"Neuroimage"},{"issue":"10","key":"208_CR15","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1002\/hbm.24235","volume":"39","author":"W Liao","year":"2018","unstructured":"Liao W, Li J, Duan X, Cui Q, Chen H, Chen H. Static and dynamic connectomics differentiate between depressed patients with and without suicidal ideation. Hum Brain Mapp. 2018;39(10):4105\u201318.","journal-title":"Hum Brain Mapp"},{"issue":"189","key":"208_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","volume":"1","author":"A Arnatkeviciute","year":"2019","unstructured":"Arnatkeviciute A, Fulcher BD, Fornito A. A practical guide to linking brain-wide gene expression and neuroimaging data. Neuroimage. 2019;1(189):353\u201367.","journal-title":"Neuroimage"},{"issue":"10","key":"208_CR17","doi-asserted-by":"publisher","first-page":"e72129","DOI":"10.7554\/eLife.72129","volume":"16","author":"RD Markello","year":"2021","unstructured":"Markello RD, Arnatkeviciute A, Poline JB, Fulcher BD, Fornito A, Misic B. Standardizing workflows in imaging transcriptomics with the abagen toolbox. Elife. 2021;16(10):e72129.","journal-title":"Elife"},{"issue":"33","key":"208_CR18","doi-asserted-by":"publisher","first-page":"e2110416119","DOI":"10.1073\/pnas.2110416119","volume":"119","author":"S Shanmugan","year":"2022","unstructured":"Shanmugan S, Seidlitz J, Cui Z, Adebimpe A, Bassett DS, Bertolero MA, et al. Sex differences in the functional topography of association networks in youth. Proc Natl Acad Sci U S A. 2022;119(33):e2110416119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"208_CR19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","volume":"930","author":"H Abdi","year":"2013","unstructured":"Abdi H, Williams LJ. Partial least squares methods: partial least squares correlation and partial least square regression. Methods Mol Biol. 2013;930:549\u201379.","journal-title":"Methods Mol Biol"},{"issue":"3","key":"208_CR20","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","volume":"59","author":"A Soltani Khaboushan","year":"2022","unstructured":"Soltani Khaboushan A, Yazdanpanah N, Rezaei N. Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis. Mol Neurobiol. 2022;59(3):1724\u201343.","journal-title":"Mol Neurobiol"},{"issue":"5","key":"208_CR21","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41583-024-00805-1","volume":"25","author":"T Ravizza","year":"2024","unstructured":"Ravizza T, Scheper M, Di Sapia R, Gorter J, Aronica E, Vezzani A. mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment. Nat Rev Neurosci. 2024;25(5):334\u201350.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"208_CR22","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"issue":"3","key":"208_CR23","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/s41380-019-0446-9","volume":"26","author":"D Sone","year":"2021","unstructured":"Sone D, Beheshti I, Maikusa N, Ota M, Kimura Y, Sato N, et al. Neuroimaging-based brain-age prediction in diverse forms of epilepsy: a signature of psychosis and beyond. Mol Psychiatry. 2021;26(3):825\u201334.","journal-title":"Mol Psychiatry"},{"issue":"10","key":"208_CR24","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1001\/jamaneurol.2019.1708","volume":"76","author":"M Galovic","year":"2019","unstructured":"Galovic M, van Dooren VQH, Postma TS, Vos SB, Caciagli L, Borz\u00ec G, et al. Progressive Cortical Thinning in Patients With Focal Epilepsy. JAMA Neurol. 2019;76(10):1230\u20139.","journal-title":"JAMA Neurol"},{"issue":"2","key":"208_CR25","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/jnnp-2013-306966","volume":"86","author":"J Stretton","year":"2015","unstructured":"Stretton J, Pope RA, Winston GP, Sidhu MK, Symms M, Duncan JS, et al. Temporal lobe epilepsy and affective disorders: the role of the subgenual anterior cingulate cortex. J Neurol Neurosurg Psychiatry. 2015;86(2):144\u201351.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"208_CR26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/brain\/awac293","volume":"146","author":"A Grote","year":"2023","unstructured":"Grote A, Heiland DH, Taube J, Helmstaedter C, Ravi VM, Will P, et al. \u201cHippocampal innate inflammatory gliosis only\u201d in pharmacoresistant temporal lobe epilepsy. Brain. 2023;146(2):549\u201360.","journal-title":"Brain"},{"key":"208_CR27","doi-asserted-by":"crossref","unstructured":"Taube J, Witt J, Grote A, et al. Preoperative and postoperative memory in epilepsy patients with \u2018gliosis only\u2019 versus hippocampal sclerosis: a matched case\u2013control study.\u00a0J Neurol Neurosurg Psychiatry.\u00a02022;93:1202\u20138.","DOI":"10.1136\/jnnp-2022-329224"},{"key":"208_CR28","doi-asserted-by":"publisher","first-page":"106858","DOI":"10.1016\/j.eplepsyres.2022.106858","volume":"180","author":"S Aulick\u00e1","year":"2022","unstructured":"Aulick\u00e1 S, \u010cesk\u00e1 K, \u0160\u00e1na J, Siegl F, Brichtov\u00e1 E, O\u0161lej\u0161kov\u00e1 H, et al. Cytokine-chemokine profiles in the hippocampus of patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy Res. 2022;180:106858.","journal-title":"Epilepsy Res"},{"issue":"8","key":"208_CR29","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","volume":"15","author":"A Vezzani","year":"2019","unstructured":"Vezzani A, Balosso S, Ravizza T. Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy. Nat Rev Neurol. 2019;15(8):459\u201372.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"208_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12031-019-01285-0","volume":"68","author":"W Zhang","year":"2019","unstructured":"Zhang W, Du Y, Zou Y, Luo J, L\u00fc Y, Yu W. Smad Anchor for Receptor Activation and Phospho-Smad3 Were Upregulated in Patients with Temporal Lobe Epilepsy. J Mol Neurosci. 2019;68(1):91\u20138.","journal-title":"J Mol Neurosci"},{"key":"208_CR31","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.eplepsyres.2018.08.004","volume":"146","author":"D Paul","year":"2018","unstructured":"Paul D, Dixit A, Srivastava A, Tripathi M, Prakash D, Sarkar C, et al. Altered transforming growth factor beta\/SMAD3 signalling in patients with hippocampal sclerosis. Epilepsy Res. 2018;146:144\u201350.","journal-title":"Epilepsy Res"},{"key":"208_CR32","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.bbi.2019.07.021","volume":"81","author":"C Kostoula","year":"2019","unstructured":"Kostoula C, Shaker T, Cerovic M, Craparotta I, Marchini S, Butti E, et al. TLR3 preconditioning induces anti-inflammatory and anti-ictogenic effects in mice mediated by the IRF3\/IFN-\u03b2 axis. Brain Behav Immun. 2019;81:598\u2013607.","journal-title":"Brain Behav Immun"},{"key":"208_CR33","doi-asserted-by":"crossref","unstructured":"Ma JH, Eo JC, Lee C, Hwang I, Choi J, Shin SJ, et al. Type I interferon signaling enhances kainic acid-induced seizure severity. bioRxiv. 2024;2024.11.13.623521.","DOI":"10.1101\/2024.11.13.623521"},{"issue":"1","key":"208_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41398-017-0085-3","volume":"8","author":"SL McElroy","year":"2018","unstructured":"McElroy SL, Winham SJ, Cuellar-Barboza AB, Colby CL, Ho AMC, Sicotte H, et al. Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. Transl Psychiatry. 2018;8(1):40.","journal-title":"Transl Psychiatry"},{"key":"208_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103536","volume":"40","author":"Q Lin","year":"2023","unstructured":"Lin Q, Li W, Li Y, Liu P, Zhang Y, Gong Q, et al. Aberrant structural rich club organization in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures. Neuroimage Clin. 2023;40: 103536.","journal-title":"Neuroimage Clin"},{"issue":"2","key":"208_CR36","doi-asserted-by":"publisher","first-page":"eabb1703","DOI":"10.1126\/sciadv.abb1703","volume":"7","author":"PS Cheah","year":"2021","unstructured":"Cheah PS, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, et al. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Sci Adv. 2021;7(2):eabb1703.","journal-title":"Sci Adv."},{"issue":"3","key":"208_CR37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/ajmg.c.31655","volume":"178","author":"DN Franz","year":"2018","unstructured":"Franz DN, Krueger DA. mTOR inhibitor therapy as a disease modifying therapy for tuberous sclerosis complex. Am J Med Genet C Semin Med Genet. 2018;178(3):365\u201373.","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"1","key":"208_CR38","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00259-023-06433-8","volume":"51","author":"L Xiao","year":"2023","unstructured":"Xiao L, Tang Y, Deng C, Li J, Li R, Zhu H, et al. Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2023;51(1):168\u201379.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"208_CR39","doi-asserted-by":"publisher","unstructured":"Li R, Xiao L, Han H, Long H, Liao W, Yang Z, et al. Transcriptionally downregulated GABAergic genes associated with synaptic density network dysfunction in temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2025. https:\/\/doi.org\/10.1007\/s00259-024-07054-5.\u00a0Online ahead of print","DOI":"10.1007\/s00259-024-07054-5"},{"key":"208_CR40","first-page":"awae207","volume":"25","author":"A Ballerini","year":"2024","unstructured":"Ballerini A, Biagioli N, Carbone C, Chiari A, Tondelli M, Vinceti G, et al. Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer\u2019s disease biomarkers. Brain. 2024;25:awae207.","journal-title":"Brain."},{"issue":"1","key":"208_CR41","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/brain\/awaa397","volume":"144","author":"E Kaestner","year":"2021","unstructured":"Kaestner E, Reyes A, Chen A, Rao J, Macari AC, Choi JY, et al. Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment. Brain. 2021;144(1):236\u201350.","journal-title":"Brain"}],"container-title":["Acta Epileptologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42494-025-00208-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s42494-025-00208-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s42494-025-00208-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T14:03:30Z","timestamp":1741097010000},"score":1,"resource":{"primary":{"URL":"https:\/\/aepi.biomedcentral.com\/articles\/10.1186\/s42494-025-00208-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["208"],"URL":"https:\/\/doi.org\/10.1186\/s42494-025-00208-4","relation":{},"ISSN":["2096-9384","2524-4434"],"issn-type":[{"value":"2096-9384","type":"print"},{"value":"2524-4434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of West China Hospital (2024\/567) and registered in the Chinese Clinical Trial Registry (ChiCTR2400086112). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dong Zhou is the associate editor of Acta Epileptologica, who was not involved in the journal\u2019s review or decisions related to this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18"}}