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Due to the association between AGP usage and rising antimicrobial resistance, the industry has explored new strategies including the use of probiotics and other microbial-based interventions to promote the development of a healthy microbiome in birds and mitigate against infections associated with food safety and food security. While previous studies have largely focused on the ability of probiotics to protect against <jats:italic>Clostridium perfringens<\/jats:italic> and <jats:italic>Salmonella enterica<\/jats:italic>, much less is known concerning their impact on <jats:italic>Campylobacter jejuni<\/jats:italic>, a near commensal of the chicken gut microbiome that nevertheless is a major cause of food poisoning in humans.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here we compare the efficacy of four microbial interventions (two single strain probiotics, the bacterium\u2014<jats:italic>Pediococcus acidilactici<\/jats:italic>, and the yeast\u2014<jats:italic>Saccharomyces cerevisiae boulardii<\/jats:italic>; and two complex, competitive exclusion, consortia\u2014Aviguard and CEL) to bacitracin, a commonly used AGP, to modulate chicken gut microbiota and subsequently impact <jats:italic>C. jejuni<\/jats:italic> infection in poultry. Cecal samples were harvested at 30- and 39-days post hatch to assess <jats:italic>Campylobacter<\/jats:italic> burden and examine their impact on the gut microbiota. While the different treatments did not significantly decrease <jats:italic>C. jejuni<\/jats:italic> burden relative to the untreated controls, both complex consortia resulted in significant decreases relative to treatment with bacitracin. Analysis of 16S rDNA profiles revealed a distinct microbial signature associated with each microbial intervention. For example, treatment with Aviguard and CEL increased the relative abundance of <jats:italic>Bacteroidaceae<\/jats:italic> and <jats:italic>Rikenellaceae<\/jats:italic> respectively. Furthermore, Aviguard promoted a less complex microbial community compared to other treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Depending upon the individual needs of the producer, our results illustrate the potential of each microbial interventions to serve flock-specific requirements.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s42523-021-00157-6","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T10:04:48Z","timestamp":1641204288000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Performance of distinct microbial based solutions in a Campylobacter infection challenge model in poultry"],"prefix":"10.1186","volume":"4","author":[{"given":"Maxine","family":"Ty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Taha-Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Demey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Castex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-1189","authenticated-orcid":false,"given":"John","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"issue":"2","key":"157_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1128\/CMR.16.2.175-188.2003","volume":"16","author":"P Butaye","year":"2003","unstructured":"Butaye P, Devriese LA, Haesebrouck F. 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