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Salting is known to enhance its effects, particularly on kidney function, but the differences in anti-atherosclerosis efficacy between RC and SRC have not been studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 491 and 501 chemical components were identified in RC and SRC, respectively, with 337 shared components. RC at a high dose (2.4\u00a0g\/kg\/d) was more effective against AS than the same dose of SRC over 12 weeks. Both RC and SRC increased SDF-1, SCF-1, and CXCR4 levels in the aorta of model mice compared to controls, suggesting these agents may protect the vascular endothelium through a related signaling axis. A gray relational analysis of 19 common components using UPLC-MS peak areas showed correlations (gray relational value\u2009&gt;\u20090.6) with serum total cholesterol and bone marrow SDF-1 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both RC and SRC have anti-AS effects, but salt-processing does not improve this activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42826-026-00288-4","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:07:31Z","timestamp":1783674451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comparative study on the pharmacological effects of Achyranthes root against atherosclerosis in ApoE\u2212\/\u2212 mice based on the spectrum-effect relationship"],"prefix":"10.1186","volume":"42","author":[{"given":"Xiaoming","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1918-8854","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"7908","key":"288_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41586-022-04673-6","volume":"605","author":"SK Mohanta","year":"2022","unstructured":"Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, et al. 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