{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:22:06Z","timestamp":1791390126124,"version":"4.3.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Shanghai Jiaotong University School of Medicine: Nursing scientific research project","award":["Jyh2211"],"award-info":[{"award-number":["Jyh2211"]}]},{"name":"High-level localuniversity construction project by Shanghai Municipal Education Commission: Shanghai Jiaotong University School of Medicine."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthroplasty"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Limited research exists on factors influencing early postoperative swelling after total knee arthroplasty (TKA). This prospective observational cohort study aims to analyze patterns and predictors of early postoperative inflammatory swelling following TKA, informing high-risk screening and interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study measured 110 TKA patients\u2019 (76.4% female, mean age 69.51\u2009\u00b1\u20097.46\u00a0years) lower limb circumference (10\u00a0cm\/5\u00a0cm above patella, patella, calf, ankle) preoperatively and postoperatively 1\u20135\u00a0days. Variables of interest included body mass index (BMI), preoperative joint pain, postoperative joint and thigh pain, cryotherapy duration, and inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Swelling peaked proximally at 5\u00a0cm above the patella on day 3 (4.16\u2009\u00b1\u20092.90\u00a0cm). Multivariable regression analysis identified BMI as a core predictor of lower limb swelling (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), with a 1-unit increase in BMI corresponding to a 0.18\u20130.24\u00a0cm increase in proximal leg circumference. Pain timing was site-specific: swelling 10\u00a0cm above the patella was associated with preoperative joint pain on touch (\u03b2\u2009=\u20090.184,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.052), calf swelling with postoperative joint pain at rest (\u03b2\u2009=\u20090.213,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.022), and ankle swelling with postoperative thigh pain at rest (\u03b2\u2009=\u20090.228,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017). Other factors and inflammatory markers were not significantly associated with swelling (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, preoperative joint pain during activity correlated with higher white blood cell (WBC) counts (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012), and postoperative thigh resting pain with elevated C-reactive protein (CRP) levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early postoperative proximal swelling following TKA warrants attention, as chronic pro-inflammatory states in obese patients and the progression of knee osteoarthritis lead to elevated inflammatory levels, exacerbating postoperative swelling. Focus should be placed on high-risk patients with obesity and preoperative joint pain on touch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ChiCTR2500098167.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s42836-025-00344-9","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:14:40Z","timestamp":1763018080000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory-induced swelling after total knee arthroplasty: Obesity and preoperative joint pain as key predictors"],"prefix":"10.1186","volume":"7","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan-jing","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"1","key":"344_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijotn.2014.03.005","volume":"19","author":"K Szots","year":"2015","unstructured":"Szots K, Pedersen PU, Hordam B, Thomsen T, Konradsen H. 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Informed consent was obtained from all subjects. All methods were carried out in accordance with relevant guidelines and regulations under ethics approval and consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"H.L. is the Guest Editor for\n                      Arthroplasty\u00a0\"Personalized Medicine in Joint Arthroplasty\"\n                      . All authors declare that they have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}