{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:15:31Z","timestamp":1763018131258,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance (CMR) in prediabetic patients presenting with chronic coronary artery disease (CCAD) versus patients with normal HbA1C. Ninety-eight patients with CCAD were recruited. All patients were screened for HbA1C levels and then underwent a CMR study to assess AD of the aortic root and the ascending and descending thoracic aorta. Patients were classified into two groups: 52 prediabetic (HbA1C 5.7\u20136.4%) (<jats:italic>study group<\/jats:italic>) and 46 with normal glycemic status (HbA1C &lt; 5.7%) (<jats:italic>control group<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AD values at the aortic root (AR) (13.93 \u00b1 5.17 vs 34.3 \u00b1 9.65 Kpa<jats:sup>-1<\/jats:sup>\u00d7 10<jats:sup>-3<\/jats:sup>), ascending aorta (AA) (13.17 \u00b1 4.81 vs 28.1 \u00b1 8.33 Kpa<jats:sup>-1<\/jats:sup>\u00d7 10<jats:sup>-3<\/jats:sup>), and descending thoracic aorta (DA) (18.12 \u00b1 4.34 vs 33.68 \u00b1 7.57 Kpa<jats:sup>-1<\/jats:sup>\u00d7 10<jats:sup>-3<\/jats:sup>) were significantly lower in the study group than in the control group (<jats:italic>P value for all was<\/jats:italic>&lt; 0.001). Twenty-eight patients fulfilled the criteria for metabolic syndrome, and in those patients, AD was significantly lower than in those without metabolic syndrome.<\/jats:p><jats:p>Aortic distensibility at the AR, AA, and DA had strong significant negative correlations with the level of glycosylated hemoglobin (AA, AR, DA;<jats:italic>r<\/jats:italic>\u2212 0.66, \u2212 0.68, \u2212 0.58, respectively)<jats:italic>(P &lt;<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AD values at different points (AR, AA, and DA) were significantly lower in prediabetic and metabolic syndrome patients than in controls. These values also showed a significant negative correlation with the levels of HBA1C.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s43044-020-0040-0","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T17:03:10Z","timestamp":1579626190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients"],"prefix":"10.1186","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-8842","authenticated-orcid":false,"given":"Nady","family":"A. Razik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. T.","family":"Kishk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeeha Younis","family":"Bakheet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Nous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel Ghany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"issue":"4","key":"40_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/01.hco.0000126581.89648.10","volume":"19","author":"JJ Izzo","year":"2004","unstructured":"Izzo JJ (2004) Arterial stiffness and the systolic hypertension syndrome. Curr Opin Cardiol 19(4):341\u2013352","journal-title":"Curr Opin Cardiol"},{"key":"40_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrendo.2014.29","volume":"10","author":"M Laakso","year":"2014","unstructured":"Laakso M, Kuusisto J (2014) Insulin resistance and hyperglycemia in cardiovascular disease development. Nat Rev Endocrinol 10:293","journal-title":"Nat Rev Endocrinol"},{"key":"40_CR3","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1161\/01.CIR.0000065222.34933.FC","volume":"107","author":"RM Henry","year":"2003","unstructured":"Henry RM, Kostense PJ, Spijkerman AM et al (2003) Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study. Circulation 107:2089\u20132095","journal-title":"Circulation"},{"key":"40_CR4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000096746","volume":"44","author":"H Yki-Jarvinen","year":"2007","unstructured":"Yki-Jarvinen H, Westerbacka J (2007) Insulin resistance, arterial stiffness, and wave reflection. Adv Cardiol 44:252\u2013260","journal-title":"Adv Cardiol"},{"key":"40_CR5","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","volume":"108","author":"MA Creager","year":"2003","unstructured":"Creager MA, Luscher TF, Cosentino F, Beckman JA (2003) Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108:1527\u20131532","journal-title":"Circulation"},{"key":"40_CR6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1161\/01.HYP.0000198539.34501.1a","volume":"47","author":"H Tomiyama","year":"2006","unstructured":"Tomiyama H, Hashimoto H, Hirayama Y et al (2006) Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose. Hypertension 47:180\u2013188","journal-title":"Hypertension"},{"key":"40_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jacc.2005.08.052","volume":"47","author":"ME Safar","year":"2006","unstructured":"Safar ME, Thomas F, Blacher J et al (2006) Metabolic syndrome and age-related progression of aortic stiffness. J Am Coll Cardiol 47:72\u201375","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"40_CR8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1161\/HYPERTENSIONAHA.109.141275","volume":"55","author":"A Redheuil","year":"2010","unstructured":"Redheuil A, Yu WC, Wu CO et al (2010) Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension. 55(2):319\u2013326","journal-title":"Hypertension."},{"key":"40_CR9","unstructured":"International Diabetes Federation. Worldwide definition of metabolic syndrome. Available at: http:\/\/www.idf.org\/webdata\/docs\/IDF_Metasyndrome_definition.pdf. Accessed 24 Aug 2005."},{"key":"40_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/jama.286.4.421","volume":"286","author":"HC Gerstein","year":"2001","unstructured":"Gerstein HC, Mann JFE, Yi Q et al (2001) Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and non-diabetic individual. JAMA 286:421\u2013426","journal-title":"JAMA"},{"key":"40_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ageing\/afl115","volume":"36","author":"F Fantin","year":"2007","unstructured":"Fantin F, Mattocks A, Bulpitt CJ, Banya W, Rajkumar C (2007) Is augmentation index a good measure of vascular stiffness in the elderly? Age Ageing 36:43\u201348","journal-title":"Age Ageing"},{"key":"40_CR12","first-page":"1","volume-title":"Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals","author":"MA Marini","year":"2012","unstructured":"Marini MA, Elena Succurro M, Ersilia Castaldo M, Giorgio Sesti M (2012) Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals, pp 1\u20136"},{"key":"40_CR13","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/jhh.2008.32","volume":"22","author":"AK Gupta","year":"2008","unstructured":"Gupta AK, Greenway FL, Cornelissen G, Pan W, Halberg F (2008) Prediabetes is associated with abnormal circadian blood pressure variability. J Hum Hypertens 22:627","journal-title":"J Hum Hypertens"},{"key":"40_CR14","first-page":"1078","volume-title":"Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension","author":"G Schillaci","year":"2005","unstructured":"Schillaci G, Pirro M, Vaudo G, Mannarino MR, Savarese G, Pucci G, Mannarino E (2005) Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension, pp 1078\u20131082"},{"key":"40_CR15","first-page":"26","volume-title":"Epidemiology\/population science modification of the effect of glycemic status on aortic distensibility by age in the multi-ethnic study of atherosclerosis","author":"RB Stacey","year":"2009","unstructured":"Stacey RB, Bertoni AG, Eng J, Bluemke DA, Hundley WG, Herrington D (2009) Epidemiology\/population science modification of the effect of glycemic status on aortic distensibility by age in the multi-ethnic study of atherosclerosis, pp 26\u201332"},{"key":"40_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2337\/diacare.24.4.683","volume":"24","author":"B Isomaa","year":"2001","unstructured":"Isomaa B, Almgren P, Tuomi T, Fors\u00e9n B, Lahti K, Niss\u00e9n M et al (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24:683\u2013689","journal-title":"Diabetes Care"},{"key":"40_CR17","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.atherosclerosis.2004.12.016","volume":"180","author":"S Li","year":"2005","unstructured":"Li S, Chen W, Srinivasan SR, Berenson GS (2005) Influence of metabolic syndrome on arterial stiffness and its age-related change in young adults: the Bogalusa Heart Study. Atherosclerosis 180:349\u2013354","journal-title":"Atherosclerosis"},{"key":"40_CR18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/00004872-200103001-00001","volume":"19","author":"L Landsberg","year":"2001","unstructured":"Landsberg L (2001) Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 19:523\u2013528 14","journal-title":"J Hypertens"},{"key":"40_CR19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1161\/hc0202.101970","volume":"105","author":"IB Wilkinson","year":"2002","unstructured":"Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR (2002) Nitric oxide regulates local arterial distensibility in vivo. Circulation 105:213\u2013217","journal-title":"Circulation"},{"key":"40_CR20","first-page":"019","volume":"44","author":"R Garcia-Carretero","year":"2019","unstructured":"Garcia-Carretero R, Vigil-Medina L, Barquero-Perez O, Ramos-Lopez J (2019) Pulse wave velocity and machine learning to predict cardiovascular outcomes in prediabetic and diabetic populations. J Med Syst. 44:019\u20131479","journal-title":"J Med Syst."},{"key":"40_CR21","doi-asserted-by":"crossref","first-page":"e012141","DOI":"10.1161\/JAHA.119.012141","volume":"8","author":"RS Vasan","year":"2019","unstructured":"Vasan RS, Short MI, Niiranen TJ, Xanthakis V, DeCarli C, Cheng S, Seshadri S, Mitchell GF (2019) Interrelations between arterial stiffness, target organ damage, and cardiovascular disease outcomes. J Am Heart Assoc. 8:e012141\u2013e012141","journal-title":"J Am Heart Assoc."},{"key":"40_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fphys.2019.00299","volume":"10","author":"G Goudot","year":"2019","unstructured":"Goudot G, Mirault T, Bruneval P, Soula G, Pernot M, Messas E (2019) Aortic wall elastic properties in case of bicuspid aortic valve. Front Physiol. 10:299","journal-title":"Front Physiol."}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-020-0040-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s43044-020-0040-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-020-0040-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:43:49Z","timestamp":1665553429000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-020-0040-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["40"],"URL":"https:\/\/doi.org\/10.1186\/s43044-020-0040-0","relation":{},"ISSN":["2090-911X"],"issn-type":[{"type":"electronic","value":"2090-911X"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"assertion":[{"value":"7 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by our local ethics committee (No. 17100819, Faculty of Medicine, Assiut University), and written consent was taken from each subject.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}