{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:29:12Z","timestamp":1762900152521,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The optimal strategy for revascularization in patients with NSTEACS who had multivessel coronary artery disease. A lack of evidence exists about the role of complete coronary revascularization by PCI in patients with non-ST segment elevation acute coronary syndrome (NSTEACS). Till now, ACC\/AHA and ESC guidelines are not clear regarding the optimal strategy for revascularization in NSTEACS patients with multivessel coronary artery disease. In this setting, identification of the culprit lesion by angiography only could be challenging. The objective is to compare the hospital and short-term (6\u2009months) outcomes of 3 different coronary revascularization strategies in NSTEACS patients with and multivessel coronary artery disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our study was a prospective study that included 90 patients who presented with acute chest pain and were diagnosed with NSTEACS. The patients were divided into 3 groups according to the plan of management: total revascularization group (total group), staged revascularization group (staged group), and functional revascularization group using FFR (FFR group). We studied the effect of demographic data, risk factors, and angiographic and procedural criteria on hospital and short-term outcomes. No significant statistical difference was seen among the three groups regarding the hospital outcome (in-stent thrombosis, unstable angina, and renal impairment). Also, the short-term (after 6\u2009months) outcome regarding myocardial infarction, hospitalization, stroke, and cardiac death did not differ significantly between the three groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Considering NSTEACS patients with multivessel disease, different coronary revascularization strategies (total, staged, or FFR) are comparable regarding immediate and short-term (6\u2009months) clinical follow-up. FFR can change the preplanned management, and less number of stents per patient is needed when FFR is utilized.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-021-00179-0","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T10:03:33Z","timestamp":1624701813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Total versus staged versus functional revascularization in NSTEACS patients with multivessel disease"],"prefix":"10.1186","volume":"73","author":[{"given":"Ahmed O.","family":"Elkady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdelghany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda","family":"Diab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Ezz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-2293","authenticated-orcid":false,"given":"Abdalla A.","family":"Elagha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"issue":"4","key":"179_CR1","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/0002-8703(91)90661-Z","volume":"121","author":"DW Muller","year":"1991","unstructured":"Muller DW, Topol EJ, Ellis SG, Sigmon KN, Lee K, Califf RM, for the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group (1991) Multivessel coronary artery disease: a key predictor of short-term prognosis after reperfusion therapy for acute myocardial infarction. Am Heart J 121(4):1042\u20131049. https:\/\/doi.org\/10.1016\/0002-8703(91)90661-Z","journal-title":"Am Heart J"},{"issue":"14","key":"179_CR2","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1093\/eurheartj\/ehq129","volume":"31","author":"M Toma","year":"2010","unstructured":"Toma M, Buller CE, Westerhout CM, Fu Y, O'Neill WW, Holmes DR, Hamm CW, Granger CB, Armstrong PW, for the APEX-AMI Investigators (2010) Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. Eur Heart J 31(14):1701\u20131707. https:\/\/doi.org\/10.1093\/eurheartj\/ehq129","journal-title":"Eur Heart J"},{"issue":"4","key":"179_CR3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.amjcard.2009.04.016","volume":"104","author":"MA Cavender","year":"2009","unstructured":"Cavender MA, Milford-Beland S, Roe MT, Peterson ED, Weintraub WS, Rao SV (2009) Prevalence, predictors, and in-hospital outcomes of non-infarct artery intervention during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (from the National Cardiovascular Data Registry). Am J Cardiol 104(4):507\u2013513. https:\/\/doi.org\/10.1016\/j.amjcard.2009.04.016","journal-title":"Am J Cardiol"},{"issue":"1","key":"179_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jcin.2009.10.017","volume":"3","author":"EL Hannan","year":"2010","unstructured":"Hannan EL, Samadashvili Z, Walford G, Holmes DR Jr, Jacobs AK, Stamato NJ, Venditti FJ, Sharma S, King SB III (2010) Culprit vessel percutaneous coronary intervention versus multivessel and staged percutaneous coronary intervention for ST-segment elevation myocardial infarction patients with multivessel disease. J Am Coll Cardiol Intv 3(1):22\u201331. https:\/\/doi.org\/10.1016\/j.jcin.2009.10.017","journal-title":"J Am Coll Cardiol Intv"},{"issue":"12","key":"179_CR5","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1056\/NEJMoa1305520","volume":"369","author":"DS Wald","year":"2013","unstructured":"Wald DS, Morris JK, Wald NJ, Chase AJ, Edwards RJ, Hughes LO, Berry C, Oldroyd KG, for the PRAMI Investigators (2013) Randomized trial of preventive angioplasty in myocardial infarction. N Engl J Med 369(12):1115\u20131123. https:\/\/doi.org\/10.1056\/NEJMoa1305520","journal-title":"N Engl J Med"},{"issue":"10","key":"179_CR6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.jacc.2014.12.038","volume":"65","author":"AH Gershlick","year":"2015","unstructured":"Gershlick AH, Khan JN, Kelly DJ, Greenwood JP, Sasikaran T, Curzen N, Blackman DJ, Dalby M, Fairbrother KL, Banya W, Wang D, Flather M, Hetherington SL, Kelion AD, Talwar S, Gunning M, Hall R, Swanton H, McCann GP (2015) Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial. J Am Coll Cardiol 65(10):963\u2013972. https:\/\/doi.org\/10.1016\/j.jacc.2014.12.038","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"179_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jacc.2015.10.082","volume":"67","author":"G Sardella","year":"2016","unstructured":"Sardella G, Lucisano L, Garbo R, Pennacchi M, Cavallo E, Stio RE, Calcagno S, Ugo F, Boccuzzi G, Fedele F, Mancone M (2016) Single staged compared with multi-staged PCI in multivessel NSTEMI patients. J Am Coll Cardiol. 67(3):264\u2013272. https:\/\/doi.org\/10.1016\/j.jacc.2015.10.082","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"179_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/eurheartj\/ehu338","volume":"36","author":"J Layland","year":"2015","unstructured":"Layland J, Oldroyd KG, Curzen N, Sood A, Balachandran K, Das R, Junejo S, Ahmed N, Lee MM, Shaukat A, O\u2019Donnell A, Nam J, Briggs A, Henderson R, McConnachie A, Berry C, FAMOUS\u2013NSTEMI investigators (2015) Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial. Eur Heart J. 36(2):100\u2013111. https:\/\/doi.org\/10.1093\/eurheartj\/ehu338","journal-title":"Eur Heart J."},{"issue":"3","key":"179_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1056\/NEJMoa0807611","volume":"360","author":"PA Tonino","year":"2009","unstructured":"Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van\u2019t Veer M, Klauss V, Manoharan G, Engstr\u00f8m T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF, FAME Study Investigators (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. 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J Am Coll Cardiol 56(3):177\u2013184. https:\/\/doi.org\/10.1016\/j.jacc.2010.04.012","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"179_CR11","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.jacc.2006.10.054","volume":"49","author":"MH Shishehbor","year":"2007","unstructured":"Shishehbor MH, Lauer MS, Singh IM, Chew DP, Karha J, Brener SJ, Moliterno DJ, Ellis SG, Topol EJ, Bhatt DL (2007) In unstable or non-ST-segment acute coronary syndrome, should patients with multivessel coronary artery disease undergo multivessel or culprit-only stenting? J Am Coll Cardiol 49(8):849\u2013854. https:\/\/doi.org\/10.1016\/j.jacc.2006.10.054","journal-title":"J Am Coll Cardiol"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-021-00179-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-021-00179-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-021-00179-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T10:03:36Z","timestamp":1624701816000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-021-00179-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["179"],"URL":"https:\/\/doi.org\/10.1186\/s43044-021-00179-0","relation":{},"ISSN":["2090-911X"],"issn-type":[{"type":"electronic","value":"2090-911X"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"7 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval was obtained from the Ethics Committee of the Cardiology Department at Cairo University (CU-2018-23). All patients provided written consent to participate.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"56"}}