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The underlying etiology for arrhythmia in these cases are mostly multifactorial as those patients may suffer from one or more of the following predisposing mechanisms; catecholamine surge, hypoxia, myocarditis, cytokine storm, QTc prolongation, electrolyte disturbance, and pro-arrhythmic drugs usage. Obviously, the risk for arrhythmia and the associated lethal outcome would rise dramatically among patients with preexisting cardiac disease such as myocardial ischemia, heart failure, cardiomyopathy, and hereditary arrhythmias. Considering all of these variables, the management strategy of COVID-19 patients should expand from managing a viral infection and related host immune response to include the prevention of predictable causes for arrhythmia. This may necessitate the need to investigate the role of some drugs that modulate the pathway of arrhythmia generation. Of these drugs, we discuss the potential role of adrenergic antagonists, trimetazidine, ranolazine, and the debatable angiotensin converting enzyme inhibitors drugs. We also recommend monitoring the level of: unbound free fatty acids, serum electrolytes, troponin, and QTc (even in the absence of apparent pro-arrhythmic drug use) as these may be the only indicators for patients at risk for arrhythmic complications.<\/jats:p>","DOI":"10.1186\/s43044-021-00201-5","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T08:17:03Z","timestamp":1630311423000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contemporary approach to understand and manage COVID-19-related arrhythmia"],"prefix":"10.1186","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-9316","authenticated-orcid":false,"given":"Omnia Azmy","family":"Nabeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-1425","authenticated-orcid":false,"given":"Maiada Mohamed","family":"Helaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-6623","authenticated-orcid":false,"given":"Rahma","family":"Menshawey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-7331","authenticated-orcid":false,"given":"Esraa","family":"Menshawey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-4926","authenticated-orcid":false,"given":"Mohammed Mansoor Matooq","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed","family":"Diaa El-deen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"issue":"5","key":"201_CR1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/jce.14479","volume":"31","author":"AN Kochi","year":"2020","unstructured":"Kochi AN, Tagliari AP, Forleo GB, Fassini GM, Tondo C (2020) Cardiac and arrhythmic complications in patients with COVID-19. 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